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Protein

Peptidyl-prolyl cis-trans isomerase CWC27 homolog

Gene

cwc27

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

PPIases accelerate the folding of proteins.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CWC27 homolog (EC:5.2.1.8)
Short name:
PPIase CWC27
Gene namesi
Name:cwc27
Synonyms:sdccag10
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-942799. cwc27.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003136531 – 477Peptidyl-prolyl cis-trans isomerase CWC27 homologAdd BLAST477

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6GLX7.
SMRiQ6GLX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili308 – 381Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi252 – 280Asp-richAdd BLAST29

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG097993.
KOiK12737.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiView protein in InterPro
IPR029000. Cyclophilin-like_dom_sf.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiView protein in Pfam
PF00160. Pro_isomerase. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiView protein in PROSITE
PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GLX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIYIQEPP SNGKVLLKTT AGEIDIELWS KEAPKACRNF VQLCLEGYYD
60 70 80 90 100
NTIFHRVVPE FIIQGGDPTG TGTGGESVFG KPFRDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTIYN ILRLAEVDIG
160 170 180 190 200
EDERPVNPHK IKCTEVLFNP FDDIIPRIDK KTKKDEEEEG KKSKAKGTKN
210 220 230 240 250
FNLLSFGEEA EEDEEEVNEV SKVMRGKSKS SHDLLKDDPR LSSVPAVERE
260 270 280 290 300
KDSQSADSDK DEDEMSDDDD EEEDDEMDSD EKHQMKDRIS NKLRKDPSKS
310 320 330 340 350
IKQAENSDEA EERKSSRSEE LRREARQLKR ELKAAKEKKE NNIKESETAK
360 370 380 390 400
EAENTVANSA LEEYLKEKEK YEEVRKKNTN KGVSREQQTL ALLDRFKSKL
410 420 430 440 450
TQAITEPPKE EEASDVDEEN DKGWLSHVLQ FEEKSGKVKD ANMQDEDTFE
460 470
IYDPRNPVNK RRREESKKIM KQKKERR
Length:477
Mass (Da):54,875
Last modified:July 19, 2004 - v1
Checksum:iAD5032026CE472D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074317 mRNA. Translation: AAH74317.1.
RefSeqiNP_001086199.1. NM_001092730.1.
UniGeneiXl.13268.

Genome annotation databases

GeneIDi444628.
KEGGixla:444628.

Similar proteinsi

Entry informationi

Entry nameiCWC27_XENLA
AccessioniPrimary (citable) accession number: Q6GLX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families