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Q6GLD8

- CDK9_XENTR

UniProt

Q6GLD8 - CDK9_XENTR

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Protein

Cyclin-dependent kinase 9

Gene

cdk9

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATPPROSITE-ProRule annotation
Active sitei153 – 1531Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi25 – 339ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_222126. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_231743. RNA Polymerase II Transcription Elongation.
REACT_255853. RNA Polymerase II Pre-transcription Events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 9 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 9
Gene namesi
Name:cdk9
ORF Names:TGas123e01.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-483721. cdk9.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 376376Cyclin-dependent kinase 9PRO_0000085806Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6GLD8.

Interactioni

Subunit structurei

Associates with cyclin-T to form P-TEFb.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GLD8.
SMRiQ6GLD8. Positions 7-329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 319301Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00770000120511.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ6GLD8.
KOiK02211.
OMAiMSLVHIK.
OrthoDBiEOG76DTSM.
TreeFamiTF101039.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GLD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV
60 70 80 90 100
LMENEKEGFP ITALREIKIL QLLKHENVVN LIEICRTKIS PTANQYNRCK
110 120 130 140 150
GTIFLVFDFC EHDLAGLLSN AHVKFTLSEI KKVMQMLLNG LYYIHRNKIL
160 170 180 190 200
HRDMKAANVL ITRDGVLKLA DFGLARAFSL AKNSQPNKYT NRVVTLWYRP
210 220 230 240 250
PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH QLTLISQLCG
260 270 280 290 300
SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDL YALDLIDKLL
310 320 330 340 350
VLDPAQRIDS DDALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG
360 370
GHMPQQPANQ ARNPAATNQS EFDRVF
Length:376
Mass (Da):43,273
Last modified:July 19, 2004 - v1
Checksum:i7C2E6045CDBEF5E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762201 mRNA. Translation: CAJ82512.1.
BC074560 mRNA. Translation: AAH74560.1.
RefSeqiNP_001005448.1. NM_001005448.1.
UniGeneiStr.64873.

Genome annotation databases

EnsembliENSXETT00000031527; ENSXETP00000031527; ENSXETG00000024742.
GeneIDi448039.
KEGGixtr:448039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762201 mRNA. Translation: CAJ82512.1 .
BC074560 mRNA. Translation: AAH74560.1 .
RefSeqi NP_001005448.1. NM_001005448.1.
UniGenei Str.64873.

3D structure databases

ProteinModelPortali Q6GLD8.
SMRi Q6GLD8. Positions 7-329.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000031527 ; ENSXETP00000031527 ; ENSXETG00000024742 .
GeneIDi 448039.
KEGGi xtr:448039.

Organism-specific databases

CTDi 1025.
Xenbasei XB-GENE-483721. cdk9.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00770000120511.
HOGENOMi HOG000233024.
HOVERGENi HBG014652.
InParanoidi Q6GLD8.
KOi K02211.
OMAi MSLVHIK.
OrthoDBi EOG76DTSM.
TreeFami TF101039.

Enzyme and pathway databases

Reactomei REACT_222126. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_231743. RNA Polymerase II Transcription Elongation.
REACT_255853. RNA Polymerase II Pre-transcription Events.

Gene expression databases

Bgeei Q6GLD8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCDK9_XENTR
AccessioniPrimary (citable) accession number: Q6GLD8
Secondary accession number(s): Q28F30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3