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Q6GLD8 (CDK9_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 9
EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cell division protein kinase 9
Gene names
Name:cdk9
ORF Names:TGas123e01.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subunit structure

Associates with cyclin-T to form P-TEFb By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376Cyclin-dependent kinase 9
PRO_0000085806

Regions

Domain19 – 319301Protein kinase
Nucleotide binding25 – 339ATP By similarity

Sites

Active site1531Proton acceptor By similarity
Binding site481ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GLD8 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 7C2E6045CDBEF5E4

FASTA37643,273
        10         20         30         40         50         60 
MAKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP 

        70         80         90        100        110        120 
ITALREIKIL QLLKHENVVN LIEICRTKIS PTANQYNRCK GTIFLVFDFC EHDLAGLLSN 

       130        140        150        160        170        180 
AHVKFTLSEI KKVMQMLLNG LYYIHRNKIL HRDMKAANVL ITRDGVLKLA DFGLARAFSL 

       190        200        210        220        230        240 
AKNSQPNKYT NRVVTLWYRP PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH 

       250        260        270        280        290        300 
QLTLISQLCG SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDL YALDLIDKLL 

       310        320        330        340        350        360 
VLDPAQRIDS DDALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG GHMPQQPANQ 

       370 
ARNPAATNQS EFDRVF

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Gastrula.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR762201 mRNA. Translation: CAJ82512.1.
BC074560 mRNA. Translation: AAH74560.1.
RefSeqNP_001005448.1. NM_001005448.1.
UniGeneStr.64873.

3D structure databases

ProteinModelPortalQ6GLD8.
SMRQ6GLD8. Positions 7-329.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000031527; ENSXETP00000031527; ENSXETG00000024742.
GeneID448039.
KEGGxtr:448039.

Organism-specific databases

CTD1025.
XenbaseXB-GENE-483721. cdk9.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00690000102025.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ6GLD8.
KOK02211.
OMAPANQARN.
OrthoDBEOG4SF963.

Gene expression databases

BgeeQ6GLD8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK9_XENTR
AccessionPrimary (citable) accession number: Q6GLD8
Secondary accession number(s): Q28F30
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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