Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cyclin-dependent kinase 9

Gene

cdk9

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) and SUPT5H.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48ATPPROSITE-ProRule annotation1
Active sitei153Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi25 – 33ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-XTR-112382. Formation of RNA Pol II elongation complex.
R-XTR-112387. Elongation arrest and recovery.
R-XTR-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-XTR-674695. RNA Polymerase II Pre-transcription Events.
R-XTR-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-XTR-6807505. RNA polymerase II transcribes snRNA genes.
R-XTR-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 9 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cell division protein kinase 9
Gene namesi
Name:cdk9
ORF Names:TGas123e01.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-483721. cdk9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858061 – 376Cyclin-dependent kinase 9Add BLAST376

Proteomic databases

PaxDbiQ6GLD8.

Expressioni

Gene expression databases

BgeeiENSXETG00000024742.

Interactioni

Subunit structurei

Associates with cyclin-T to form P-TEFb.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000031527.

Structurei

3D structure databases

ProteinModelPortaliQ6GLD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 319Protein kinasePROSITE-ProRule annotationAdd BLAST301

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ6GLD8.
KOiK02211.
OMAiICRTKAN.
OrthoDBiEOG091G08Z8.
TreeFamiTF101039.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GLD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNYDSVEF PYCDEVSKYE RLAKIGQGTF GEVFKAKHRQ TGKKVALKKV
60 70 80 90 100
LMENEKEGFP ITALREIKIL QLLKHENVVN LIEICRTKIS PTANQYNRCK
110 120 130 140 150
GTIFLVFDFC EHDLAGLLSN AHVKFTLSEI KKVMQMLLNG LYYIHRNKIL
160 170 180 190 200
HRDMKAANVL ITRDGVLKLA DFGLARAFSL AKNSQPNKYT NRVVTLWYRP
210 220 230 240 250
PELLLGERDY GPPIDLWGAG CIMAEMWTRS PIMQGNTEQH QLTLISQLCG
260 270 280 290 300
SITPEVWPNV DKYELYQKLE LPKGQKRKVK ERLKAYVKDL YALDLIDKLL
310 320 330 340 350
VLDPAQRIDS DDALNHDFFW SDPMPSDLKN MLSTHNQSMF EYLAPPRRRG
360 370
GHMPQQPANQ ARNPAATNQS EFDRVF
Length:376
Mass (Da):43,273
Last modified:July 19, 2004 - v1
Checksum:i7C2E6045CDBEF5E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762201 mRNA. Translation: CAJ82512.1.
BC074560 mRNA. Translation: AAH74560.1.
RefSeqiNP_001005448.1. NM_001005448.1.
UniGeneiStr.64873.

Genome annotation databases

EnsembliENSXETT00000031527; ENSXETP00000031527; ENSXETG00000024742.
GeneIDi448039.
KEGGixtr:448039.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762201 mRNA. Translation: CAJ82512.1.
BC074560 mRNA. Translation: AAH74560.1.
RefSeqiNP_001005448.1. NM_001005448.1.
UniGeneiStr.64873.

3D structure databases

ProteinModelPortaliQ6GLD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000031527.

Proteomic databases

PaxDbiQ6GLD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000031527; ENSXETP00000031527; ENSXETG00000024742.
GeneIDi448039.
KEGGixtr:448039.

Organism-specific databases

CTDi1025.
XenbaseiXB-GENE-483721. cdk9.

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
HOGENOMiHOG000233024.
HOVERGENiHBG014652.
InParanoidiQ6GLD8.
KOiK02211.
OMAiICRTKAN.
OrthoDBiEOG091G08Z8.
TreeFamiTF101039.

Enzyme and pathway databases

ReactomeiR-XTR-112382. Formation of RNA Pol II elongation complex.
R-XTR-112387. Elongation arrest and recovery.
R-XTR-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-XTR-674695. RNA Polymerase II Pre-transcription Events.
R-XTR-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-XTR-6807505. RNA polymerase II transcribes snRNA genes.
R-XTR-75955. RNA Polymerase II Transcription Elongation.

Gene expression databases

BgeeiENSXETG00000024742.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK9_XENTR
AccessioniPrimary (citable) accession number: Q6GLD8
Secondary accession number(s): Q28F30
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.