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Protein

S-adenosylmethionine mitochondrial carrier protein

Gene

slc25a26

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine mitochondrial carrier protein
Alternative name(s):
Mitochondrial S-adenosylmethionine transporter
Solute carrier family 25 member 26
Gene namesi
Name:slc25a26
Synonyms:samc
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-991471. slc25a26.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei84 – 10421Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei181 – 20121Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269S-adenosylmethionine mitochondrial carrier proteinPRO_0000317591Add
BLAST

Proteomic databases

PaxDbiQ6GLA2.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000056365.

Structurei

3D structure databases

ProteinModelPortaliQ6GLA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati4 – 7774Solcar 1Add
BLAST
Repeati85 – 16783Solcar 2Add
BLAST
Repeati176 – 26489Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ6GLA2.
KOiK15111.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GLA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERREFCASL LAGGTAGMCV DLILFPLDTI KTRLQSPLGF SKSGGFRGIY
60 70 80 90 100
AGVPSTAVGS FPNAAAFFVT YESAKQLLRS DSSYLSPIIH MAAASLGEVV
110 120 130 140 150
ACLIRVPSEV IKQRAQVSPS STTYQMLSAT LRQEGIKGLY RGYKSTVLRE
160 170 180 190 200
IPFSLVQFPL WESLKDLWSW KQGRAVDSWQ SAVCGAFAGG FAAALTTPLD
210 220 230 240 250
VAKTRIMLAK AGSGVASGNV LFALHEIWRT QGIMGLFAGV IPRMTAISLG
260
GFIFLGAYDK VRTLMLREQ
Length:269
Mass (Da):29,020
Last modified:July 19, 2004 - v1
Checksum:iD23A798DCDDE1863
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074600 mRNA. Translation: AAH74600.1.
RefSeqiNP_001004820.1. NM_001004820.1.
UniGeneiStr.52379.

Genome annotation databases

GeneIDi448074.
KEGGixtr:448074.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074600 mRNA. Translation: AAH74600.1.
RefSeqiNP_001004820.1. NM_001004820.1.
UniGeneiStr.52379.

3D structure databases

ProteinModelPortaliQ6GLA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000056365.

Proteomic databases

PaxDbiQ6GLA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448074.
KEGGixtr:448074.

Organism-specific databases

CTDi115286.
XenbaseiXB-GENE-991471. slc25a26.

Phylogenomic databases

eggNOGiKOG0768. Eukaryota.
ENOG4110BII. LUCA.
HOGENOMiHOG000038810.
HOVERGENiHBG108456.
InParanoidiQ6GLA2.
KOiK15111.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 4 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSAMC_XENTR
AccessioniPrimary (citable) accession number: Q6GLA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 19, 2004
Last modified: February 17, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.