Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6GL44

- OTUD5_XENTR

UniProt

Q6GL44 - OTUD5_XENTR

Protein

OTU domain-containing protein 5

Gene

otud5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei179 – 1791Sequence Analysis
    Active sitei182 – 1821NucleophileBy similarity
    Active sitei287 – 2871By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K48-linked deubiquitination Source: UniProtKB
    2. protein K63-linked deubiquitination Source: UniProtKB
    3. response to lipopolysaccharide Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC85.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 5 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme A
    Short name:
    DUBA
    Gene namesi
    Name:otud5
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-6455884. otud5.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518OTU domain-containing protein 5PRO_0000278229Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GL44.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini171 – 294124OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni176 – 1827Cys-loopBy similarity
    Regioni231 – 24111Variable-loopBy similarityAdd
    BLAST
    Regioni282 – 2876His-loopBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 7167Pro-richAdd
    BLAST
    Compositional biasi92 – 10211Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C85 family.Curated
    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG060214.
    KOiK12655.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GL44-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTILPKKKPP PPSDPEGNGE RSGSGGADSH SRSGARPRSS PPPRWAYPGN    50
    PAPPERHPAG TPRPQQASPP PCSGGSGGAG SGPLGEGALG PCCCCTGAGG 100
    CCSGPGHSKR RRQGVSAGPG APGSSPDRED GAGNNSEDEY ETAARTQAID 150
    PDTAEQQEHW FEKALQEKKG FIIKQMKEDG ACLFRAVADQ VYGDQDMHEV 200
    VRKHCMDYLM KNADYFSNYV TEDFTTYINR KRKNNCHGNH IEMQAMAEMY 250
    NRPVEVYQYG TEPINTFHGI QQNEDEPIRV SYHRNIHYNS VVNPNKATIG 300
    VGLGLPSFKP GFAEQSLMKS AIRTSEESWI EQQMLEDKKR ATDWEATNEA 350
    IEEQVARESY LQWLRDQEKQ ARQPRKASAT CSSATAAASS GLEEWSGRSP 400
    RQRSTAGSPE HPDLHAELCM KPPSPAATLM LGKPPSPCAP GPSNQTCAGA 450
    DRATSPLVSL YPALECRAIM QHMSPTAFGL KDWDDDEILA SVLAVSQQEY 500
    LDTIKKSTLR RDSSPDHS 518
    Length:518
    Mass (Da):56,332
    Last modified:July 19, 2004 - v1
    Checksum:i69368C93932208F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074667 mRNA. Translation: AAH74667.1.
    RefSeqiNP_001004849.1. NM_001004849.1.
    UniGeneiStr.8037.

    Genome annotation databases

    GeneIDi448134.
    KEGGixtr:448134.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074667 mRNA. Translation: AAH74667.1 .
    RefSeqi NP_001004849.1. NM_001004849.1.
    UniGenei Str.8037.

    3D structure databases

    ProteinModelPortali Q6GL44.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C85.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 448134.
    KEGGi xtr:448134.

    Organism-specific databases

    CTDi 55593.
    Xenbasei XB-GENE-6455884. otud5.

    Phylogenomic databases

    HOVERGENi HBG060214.
    KOi K12655.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiOTUD5_XENTR
    AccessioniPrimary (citable) accession number: Q6GL44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 20, 2007
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3