Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q6GL44 (OTUD5_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 5

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme A
Short name=DUBA
Gene names
Name:otud5
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sequence similarities

Belongs to the peptidase C85 family.

Contains 1 OTU domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518OTU domain-containing protein 5
PRO_0000278229

Regions

Domain171 – 294124OTU
Region176 – 1827Cys-loop By similarity
Region231 – 24111Variable-loop By similarity
Region282 – 2876His-loop By similarity
Compositional bias5 – 7167Pro-rich
Compositional bias92 – 10211Cys-rich

Sites

Active site1791 Potential
Active site1821Nucleophile By similarity
Active site2871 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GL44 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 69368C93932208F4

FASTA51856,332
        10         20         30         40         50         60 
MTILPKKKPP PPSDPEGNGE RSGSGGADSH SRSGARPRSS PPPRWAYPGN PAPPERHPAG 

        70         80         90        100        110        120 
TPRPQQASPP PCSGGSGGAG SGPLGEGALG PCCCCTGAGG CCSGPGHSKR RRQGVSAGPG 

       130        140        150        160        170        180 
APGSSPDRED GAGNNSEDEY ETAARTQAID PDTAEQQEHW FEKALQEKKG FIIKQMKEDG 

       190        200        210        220        230        240 
ACLFRAVADQ VYGDQDMHEV VRKHCMDYLM KNADYFSNYV TEDFTTYINR KRKNNCHGNH 

       250        260        270        280        290        300 
IEMQAMAEMY NRPVEVYQYG TEPINTFHGI QQNEDEPIRV SYHRNIHYNS VVNPNKATIG 

       310        320        330        340        350        360 
VGLGLPSFKP GFAEQSLMKS AIRTSEESWI EQQMLEDKKR ATDWEATNEA IEEQVARESY 

       370        380        390        400        410        420 
LQWLRDQEKQ ARQPRKASAT CSSATAAASS GLEEWSGRSP RQRSTAGSPE HPDLHAELCM 

       430        440        450        460        470        480 
KPPSPAATLM LGKPPSPCAP GPSNQTCAGA DRATSPLVSL YPALECRAIM QHMSPTAFGL 

       490        500        510 
KDWDDDEILA SVLAVSQQEY LDTIKKSTLR RDSSPDHS 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC074667 mRNA. Translation: AAH74667.1.
RefSeqNP_001004849.1. NM_001004849.1.
UniGeneStr.8037.

3D structure databases

ProteinModelPortalQ6GL44.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC85.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID448134.
KEGGxtr:448134.

Organism-specific databases

CTD55593.
XenbaseXB-GENE-6455884. otud5.

Phylogenomic databases

HOVERGENHBG060214.
KOK12655.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOTUD5_XENTR
AccessionPrimary (citable) accession number: Q6GL44
Entry history
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries