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Q6GL44

- OTUD5_XENTR

UniProt

Q6GL44 - OTUD5_XENTR

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Protein

OTU domain-containing protein 5

Gene
otud5
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei179 – 1791 Reviewed prediction
Active sitei182 – 1821Nucleophile By similarity
Active sitei287 – 2871 By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K48-linked deubiquitination Source: UniProtKB
  2. protein K63-linked deubiquitination Source: UniProtKB
  3. response to lipopolysaccharide Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC85.001.

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 5 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme A
Short name:
DUBA
Gene namesi
Name:otud5
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-6455884. otud5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518OTU domain-containing protein 5PRO_0000278229Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6GL44.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini171 – 294124OTUAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 1827Cys-loop By similarity
Regioni231 – 24111Variable-loop By similarityAdd
BLAST
Regioni282 – 2876His-loop By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 7167Pro-richAdd
BLAST
Compositional biasi92 – 10211Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C85 family.
Contains 1 OTU domain.

Phylogenomic databases

HOVERGENiHBG060214.
KOiK12655.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GL44-1 [UniParc]FASTAAdd to Basket

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MTILPKKKPP PPSDPEGNGE RSGSGGADSH SRSGARPRSS PPPRWAYPGN    50
PAPPERHPAG TPRPQQASPP PCSGGSGGAG SGPLGEGALG PCCCCTGAGG 100
CCSGPGHSKR RRQGVSAGPG APGSSPDRED GAGNNSEDEY ETAARTQAID 150
PDTAEQQEHW FEKALQEKKG FIIKQMKEDG ACLFRAVADQ VYGDQDMHEV 200
VRKHCMDYLM KNADYFSNYV TEDFTTYINR KRKNNCHGNH IEMQAMAEMY 250
NRPVEVYQYG TEPINTFHGI QQNEDEPIRV SYHRNIHYNS VVNPNKATIG 300
VGLGLPSFKP GFAEQSLMKS AIRTSEESWI EQQMLEDKKR ATDWEATNEA 350
IEEQVARESY LQWLRDQEKQ ARQPRKASAT CSSATAAASS GLEEWSGRSP 400
RQRSTAGSPE HPDLHAELCM KPPSPAATLM LGKPPSPCAP GPSNQTCAGA 450
DRATSPLVSL YPALECRAIM QHMSPTAFGL KDWDDDEILA SVLAVSQQEY 500
LDTIKKSTLR RDSSPDHS 518
Length:518
Mass (Da):56,332
Last modified:July 19, 2004 - v1
Checksum:i69368C93932208F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074667 mRNA. Translation: AAH74667.1.
RefSeqiNP_001004849.1. NM_001004849.1.
UniGeneiStr.8037.

Genome annotation databases

GeneIDi448134.
KEGGixtr:448134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074667 mRNA. Translation: AAH74667.1 .
RefSeqi NP_001004849.1. NM_001004849.1.
UniGenei Str.8037.

3D structure databases

ProteinModelPortali Q6GL44.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C85.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448134.
KEGGi xtr:448134.

Organism-specific databases

CTDi 55593.
Xenbasei XB-GENE-6455884. otud5.

Phylogenomic databases

HOVERGENi HBG060214.
KOi K12655.

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiOTUD5_XENTR
AccessioniPrimary (citable) accession number: Q6GL44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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