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Q6GL33

- PGAM5_XENTR

UniProt

Q6GL33 - PGAM5_XENTR

Protein

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Gene

pgam5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics By similarity. May be a central mediator for programmed necrosis By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. programmed cell death Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Necrosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5
    Gene namesi
    Name:pgam5
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-948920. pgam5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Serine/threonine-protein phosphatase PGAM5, mitochondrialPRO_0000288787Add
    BLAST

    Post-translational modificationi

    Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity By similarity.By similarity

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000051391.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GL33.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG71348.
    HOGENOMiHOG000261217.
    HOVERGENiHBG105576.
    InParanoidiQ6GL33.
    KOiK15637.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GL33-1 [UniParc]FASTAAdd to Basket

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    MYLRKALIAG GSAAAAAAAI LGAAAVGKSK GGPDLDILSV VPAATGQWDR    50
    NWDRREPISM VNLSKINGET GEEELQLHLN KHKPKATRHI FLIRHSQYKQ 100
    DGKTDFDRVL TPLGREQADL TGKRLSSLGF KYNHIVYSTM TRAKETTEII 150
    SKYLPDVKKS SSDLLREGAP IRPEPQVCHW KPDFVYYEDG SRIEAAFRHF 200
    IHRADPKQEA DSYEILICHA NVIRYIVCRA LQLPPEAWLR MFLNNGSISY 250
    LVIRPNGNVS LRMLGDSGFM PPEKISRT 278
    Length:278
    Mass (Da):31,211
    Last modified:July 19, 2004 - v1
    Checksum:i67923E297F554639
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074682 mRNA. Translation: AAH74682.1.
    RefSeqiNP_001004858.1. NM_001004858.1.
    UniGeneiStr.1334.

    Genome annotation databases

    GeneIDi448148.
    KEGGixtr:448148.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074682 mRNA. Translation: AAH74682.1 .
    RefSeqi NP_001004858.1. NM_001004858.1.
    UniGenei Str.1334.

    3D structure databases

    ProteinModelPortali Q6GL33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000051391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 448148.
    KEGGi xtr:448148.

    Organism-specific databases

    CTDi 192111.
    Xenbasei XB-GENE-948920. pgam5.

    Phylogenomic databases

    eggNOGi NOG71348.
    HOGENOMi HOG000261217.
    HOVERGENi HBG105576.
    InParanoidi Q6GL33.
    KOi K15637.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiPGAM5_XENTR
    AccessioniPrimary (citable) accession number: Q6GL33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3