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Q6GL33 (PGAM5_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PGAM5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5
Gene names
Name:pgam5
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics By similarity. May be a central mediator for programmed necrosis By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Domain

The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane By similarity.

Post-translational modification

Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
   Biological processNecrosis
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprogrammed cell death

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Serine/threonine-protein phosphatase PGAM5, mitochondrial
PRO_0000288787

Regions

Transmembrane7 – 2721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6GL33 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 67923E297F554639

FASTA27831,211
        10         20         30         40         50         60 
MYLRKALIAG GSAAAAAAAI LGAAAVGKSK GGPDLDILSV VPAATGQWDR NWDRREPISM 

        70         80         90        100        110        120 
VNLSKINGET GEEELQLHLN KHKPKATRHI FLIRHSQYKQ DGKTDFDRVL TPLGREQADL 

       130        140        150        160        170        180 
TGKRLSSLGF KYNHIVYSTM TRAKETTEII SKYLPDVKKS SSDLLREGAP IRPEPQVCHW 

       190        200        210        220        230        240 
KPDFVYYEDG SRIEAAFRHF IHRADPKQEA DSYEILICHA NVIRYIVCRA LQLPPEAWLR 

       250        260        270 
MFLNNGSISY LVIRPNGNVS LRMLGDSGFM PPEKISRT 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC074682 mRNA. Translation: AAH74682.1.
RefSeqNP_001004858.1. NM_001004858.1.
UniGeneStr.1334.

3D structure databases

ProteinModelPortalQ6GL33.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000051391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID448148.
KEGGxtr:448148.

Organism-specific databases

CTD192111.
XenbaseXB-GENE-948920. pgam5.

Phylogenomic databases

eggNOGNOG71348.
HOGENOMHOG000261217.
HOVERGENHBG105576.
InParanoidQ6GL33.
KOK15637.

Family and domain databases

InterProIPR013078. His_Pase_superF_clade-1.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGAM5_XENTR
AccessionPrimary (citable) accession number: Q6GL33
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families