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Protein

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Gene

pgam5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics (By similarity). May be a central mediator for programmed necrosis (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Necrosis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5
Gene namesi
Name:pgam5
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-948920. pgam5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Serine/threonine-protein phosphatase PGAM5, mitochondrialPRO_0000288787Add
BLAST

Post-translational modificationi

Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051391.

Structurei

3D structure databases

ProteinModelPortaliQ6GL33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71348.
HOGENOMiHOG000261217.
HOVERGENiHBG105576.
InParanoidiQ6GL33.
KOiK15637.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GL33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLRKALIAG GSAAAAAAAI LGAAAVGKSK GGPDLDILSV VPAATGQWDR
60 70 80 90 100
NWDRREPISM VNLSKINGET GEEELQLHLN KHKPKATRHI FLIRHSQYKQ
110 120 130 140 150
DGKTDFDRVL TPLGREQADL TGKRLSSLGF KYNHIVYSTM TRAKETTEII
160 170 180 190 200
SKYLPDVKKS SSDLLREGAP IRPEPQVCHW KPDFVYYEDG SRIEAAFRHF
210 220 230 240 250
IHRADPKQEA DSYEILICHA NVIRYIVCRA LQLPPEAWLR MFLNNGSISY
260 270
LVIRPNGNVS LRMLGDSGFM PPEKISRT
Length:278
Mass (Da):31,211
Last modified:July 19, 2004 - v1
Checksum:i67923E297F554639
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074682 mRNA. Translation: AAH74682.1.
RefSeqiNP_001004858.1. NM_001004858.1.
UniGeneiStr.1334.

Genome annotation databases

GeneIDi448148.
KEGGixtr:448148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074682 mRNA. Translation: AAH74682.1.
RefSeqiNP_001004858.1. NM_001004858.1.
UniGeneiStr.1334.

3D structure databases

ProteinModelPortaliQ6GL33.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448148.
KEGGixtr:448148.

Organism-specific databases

CTDi192111.
XenbaseiXB-GENE-948920. pgam5.

Phylogenomic databases

eggNOGiNOG71348.
HOGENOMiHOG000261217.
HOVERGENiHBG105576.
InParanoidiQ6GL33.
KOiK15637.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiPGAM5_XENTR
AccessioniPrimary (citable) accession number: Q6GL33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2004
Last modified: May 27, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.