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Q6GL33

- PGAM5_XENTR

UniProt

Q6GL33 - PGAM5_XENTR

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Protein

Serine/threonine-protein phosphatase PGAM5, mitochondrial

Gene
pgam5
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics By similarity. May be a central mediator for programmed necrosis By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. programmed cell death Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Necrosis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PGAM5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5
Gene namesi
Name:pgam5
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-948920. pgam5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Serine/threonine-protein phosphatase PGAM5, mitochondrialPRO_0000288787Add
BLAST

Post-translational modificationi

Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity By similarity.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000051391.

Structurei

3D structure databases

ProteinModelPortaliQ6GL33.

Family & Domainsi

Domaini

The N-terminal 35 amino acids, including the potential transmembrane alpha-helix, function as a non-cleaved mitochondrial targeting sequence that targets the protein to the cytosolic side of the outer mitochondrial membrane By similarity.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG71348.
HOGENOMiHOG000261217.
HOVERGENiHBG105576.
InParanoidiQ6GL33.
KOiK15637.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GL33-1 [UniParc]FASTAAdd to Basket

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MYLRKALIAG GSAAAAAAAI LGAAAVGKSK GGPDLDILSV VPAATGQWDR    50
NWDRREPISM VNLSKINGET GEEELQLHLN KHKPKATRHI FLIRHSQYKQ 100
DGKTDFDRVL TPLGREQADL TGKRLSSLGF KYNHIVYSTM TRAKETTEII 150
SKYLPDVKKS SSDLLREGAP IRPEPQVCHW KPDFVYYEDG SRIEAAFRHF 200
IHRADPKQEA DSYEILICHA NVIRYIVCRA LQLPPEAWLR MFLNNGSISY 250
LVIRPNGNVS LRMLGDSGFM PPEKISRT 278
Length:278
Mass (Da):31,211
Last modified:July 19, 2004 - v1
Checksum:i67923E297F554639
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074682 mRNA. Translation: AAH74682.1.
RefSeqiNP_001004858.1. NM_001004858.1.
UniGeneiStr.1334.

Genome annotation databases

GeneIDi448148.
KEGGixtr:448148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074682 mRNA. Translation: AAH74682.1 .
RefSeqi NP_001004858.1. NM_001004858.1.
UniGenei Str.1334.

3D structure databases

ProteinModelPortali Q6GL33.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000051391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448148.
KEGGi xtr:448148.

Organism-specific databases

CTDi 192111.
Xenbasei XB-GENE-948920. pgam5.

Phylogenomic databases

eggNOGi NOG71348.
HOGENOMi HOG000261217.
HOVERGENi HBG105576.
InParanoidi Q6GL33.
KOi K15637.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiPGAM5_XENTR
AccessioniPrimary (citable) accession number: Q6GL33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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