ID   Q6GL17_XENTR            Unreviewed;       284 AA.
AC   Q6GL17;
DT   19-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 114.
DE   SubName: Full=Isocitrate dehydrogenase [NADP] cytoplasmic {ECO:0000313|RefSeq:NP_001004863.1};
DE            EC=1.1.1.42 {ECO:0000313|RefSeq:NP_001004863.1};
DE   SubName: Full=MGC69225 protein {ECO:0000313|EMBL:AAH74702.1};
GN   Name=idh1 {ECO:0000313|RefSeq:NP_001004863.1,
GN   ECO:0000313|Xenbase:XB-GENE-1004994};
GN   Synonyms=MGC69225 {ECO:0000313|EMBL:AAH74702.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH74702.1};
RN   [1] {ECO:0000313|RefSeq:NP_001004863.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH74702.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH74702.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001004863.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; BC074702; AAH74702.1; -; mRNA.
DR   RefSeq; NP_001004863.1; NM_001004863.1.
DR   DNASU; 448164; -.
DR   GeneID; 448164; -.
DR   KEGG; xtr:448164; -.
DR   AGR; Xenbase:XB-GENE-1004994; -.
DR   CTD; 3417; -.
DR   Xenbase; XB-GENE-1004994; idh1.
DR   HOGENOM; CLU_023296_1_1_1; -.
DR   OMA; HGTVQRH; -.
DR   OrthoDB; 423at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006102; P:isocitrate metabolic process; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR004790; Isocitrate_DH_NADP.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   NCBIfam; TIGR00127; nadp_idh_euk; 1.
DR   PANTHER; PTHR11822:SF21; ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11822; NADP-SPECIFIC ISOCITRATE DEHYDROGENASE; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   2: Evidence at transcript level;
KW   Glyoxylate bypass {ECO:0000256|ARBA:ARBA00022435};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532}.
FT   DOMAIN          9..284
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   284 AA;  32326 MW;  28302B9D9E75CB9E CRC64;
     MSKKINGGSV VEMQGDEMTR VIWDLIKEKL ILPYVELDLH CYDLGIENRD ATDDQVTVDA
     AEAIKKYNVG IKCATITPDE KRVEEFNLKQ MWKSPNGTIR NILGGTVFRE AIICKNIPRL
     VSGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEISFTPKD GGEAIKYVIH NFEDCGGVAL
     GMYNTDQSIR DFAHSSFQMA LSKSWPLYMS TKNTILKKYD GRFKDIFQEI YEKDYKSQFE
     EKKIWYEHRL IDDMVAQAMK SEGGFIWACK NYDGDVQSDS VAQG
//