Q6GL12 (SPS1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Selenide, water dikinase 1
EC=2.7.9.3

Alternative name(s):
Selenium donor protein 1
Selenophosphate synthase 1

Gene names

Name:

sephs1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	392 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Synthesizes selenophosphate from selenide and ATP By similarity.
Catalytic activity	ATP + selenide + H2O = AMP + selenophosphate + phosphate.
Sequence similarities	Belongs to the selenophosphate synthase 1 family. Class II subfamily.
Caution	The conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr. However, as function in selenoprotein synthesis is probable, it is possible Cys-31 is the active site.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding Selenium
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW selenide, water dikinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 392	392	Selenide, water dikinase 1		PRO_0000312510
Regions
	Nucleotide binding	67 – 69	3	ATP By similarity
	Nucleotide binding	162 – 164	3	ATP; shared with dimeric partner By similarity
	Nucleotide binding	267 – 273	7	ATP By similarity
Sites
	Active site	31	1	Potential
	Binding site	32	1	ATP By similarity
	Binding site	87	1	ATP By similarity
	Binding site	110	1	ATP By similarity
	Site	32	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GL12 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: DB276A3FEBE8C31E	FASTA	392	42,818
	10 20 30 40 50 60 MSVRESFNPE SYELDKSFRL TRFAELKGTG CKVPQDVLQK LLESLQENHF QEDEQFLGAV 70 80 90 100 110 120 MPRLGIGMDT CVIPLRHGGL SLVQTTDYIY PIVDDPYMMG RIACANVLSD LYAMGVTECD 130 140 150 160 170 180 NMLMLLGVSN KLTDRERDKV MPLIIQGFKD AAEEAGTSVT GGQTVLNPWV VLGGVATTVC 190 200 210 220 230 240 QPNEFIMPDN AVPGDVLVLT KPLGTQVAVA VHQWLDIPEK WNKIKLVVTQ EDVELAYQEA 250 260 270 280 290 300 MMNMARLNRT AAGLMHTFNA HAATDITGFG ILGHAQNLAK QQRNEVSFVI HNLPVLAKMA 310 320 330 340 350 360 AVSKACGNMF GLMHGSCPET SGGLLICLPR EQAARFCAEI KSPKYGEGHQ AWIIGIVEKG 370 380 390 NRTARIIDKP RIIEVAPQVA SQNVNPTPGA TS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074707 mRNA. Translation: AAH74707.1.
RefSeq	NP_001006902.1. NM_001006901.1.
UniGene	Str.18431.
3D structure databases
ProteinModelPortal	Q6GL12.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GL12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	448749.
KEGG	xtr:448749.
Organism-specific databases
CTD	22929.
Xenbase	XB-GENE-986440. sephs1.
Phylogenomic databases
eggNOG	veNOG09639.
GeneTree	ENSGT00390000000950.
HOGENOM	HBG383791.
HOVERGEN	HBG001207.
InParanoid	Q6GL12.
OrthoDB	EOG4ZW5B4.
Family and domain databases
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR016188. PurM_N-like. IPR004536. SelD. [Graphical view]
KO	K01008.
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
PIRSF	PIRSF036407. Selenphspht_syn. 1 hit.
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00476. SelD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SPS1_XENTR

Accession

Primary (citable) accession number: Q6GL12

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	July 19, 2004
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program