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Q6GL04

- TERA_XENTR

UniProt

Q6GL04 - TERA_XENTR

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Protein
Transitional endoplasmic reticulum ATPase
Gene
vcp
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites By similarity.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Enzyme regulationi

ATPase activity is inhibited or reduced by lowering pH from 9.0 to 7.0, and by addition of Ca2+, EDTA, KNO3 or by treatment with N-ethylmaleimide (NEM) By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei348 – 3481ATP By similarity
Binding sitei384 – 3841ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2537ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: UniProtKB
  3. lipid binding Source: UniProtKB-KW
  4. protein complex binding Source: UniProtKB

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  3. cellular response to DNA damage stimulus Source: UniProtKB
  4. double-strand break repair Source: UniProtKB
  5. protein N-linked glycosylation via asparagine Source: UniProtKB
  6. protein hexamerization Source: UniProtKB
  7. protein ubiquitination Source: UniProtKB
  8. translesion synthesis Source: UniProtKB
  9. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage, DNA repair, Transport

Keywords - Ligandi

ATP-binding, Lipid-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transitional endoplasmic reticulum ATPase (EC:3.6.4.6)
Short name:
TER ATPase
Alternative name(s):
15S Mg(2+)-ATPase p97 subunit
Short name:
p97
Valosin-containing protein
Short name:
VCP
Gene namesi
Name:vcp
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-969573. vcp.

Subcellular locationi

Cytoplasmcytosol By similarity. Nucleus By similarity
Note: Following DNA double-strand breaks, recruited to the sites of damage By similarity.By similarity

GO - Cellular componenti

  1. chromatin Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytosol Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB
  5. site of double-strand break Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Transitional endoplasmic reticulum ATPase
PRO_0000382234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31Phosphoserine By similarityBy similarity

Post-translational modificationi

Phosphorylated By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6GL04.
PRIDEiQ6GL04.

Interactioni

Subunit structurei

Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Interacts with the FACT/DUF complex, which includes subunits ssrp1/duf87 and supt16h/duf140 By similarity.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000054726.

Structurei

3D structure databases

ProteinModelPortaliQ6GL04.
SMRiQ6GL04. Positions 21-763.

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.

Phylogenomic databases

eggNOGiCOG0464.
HOGENOMiHOG000223224.
InParanoidiQ6GL04.
KOiK13525.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GL04-1 [UniParc]FASTAAdd to Basket

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MASGSDSKSD DLSTAILKQK SRPNRLIVDE SINEDNSVVS LSQAKMDELQ    50
LFRGDTVLLK GKKRREAVCI VLSDDTCSDE KIRMNRVVRN NLRVRLGDVI 100
SIQPCPDVKY GKRIHVLPID DTVEGITGNL FEVYLKPYFL EAYRPIRKGD 150
IFLVRGGMRA VEFKVVETDP SPYCIVAPDT VIHCEGEPIK REDEEESLNE 200
VGYDDIGGCR KQLAQIKEMV ELPLRHPALF KAIGVKPPRG ILLYGPPGTG 250
KTLIARAVAN ETGAFFFLIN GPEIMSKLAG ESESNLRKAF EEAEKNAPAI 300
IFIDELDAIA PKREKTHGEV ERRIVSQLLT LMDGLKQRAH VIVMAATNRP 350
NSIDPALRRF GRFDREVDIG IPDSTGRLEI LQIHTKNMKL SDDVDLEQVA 400
NETHGHVGAD LAALCSEAAL QAIRKKMDLI DLEDETIDAE VMNSLAVTMD 450
DFRWALSQSN PSALRETVVE VPQVTWEDIG GLEDVKRELQ ELVQYPVEHP 500
DKFLKFGMTP SKGVLFYGPP GCGKTLLAKA IANECQANFI SIKGPELLTM 550
WFGESEANVR EIFDKARQAA PCVLFFDELD SIAKARGGNI GDGGGAADRV 600
INQILTEMDG MSTKKNVFII GATNRPDIID PAILRPGRLD QLIYIPLPDE 650
KSRIAILKAN LRKSPVAKDV DLDFLAKMTN GFSGADLTEI CQRACKLAIR 700
ESIENEIRRE RERQTNPSAM EVEEDDPVPE IRRDHFEEAM RFARRSVSDN 750
DIRKYEMFAQ TLQQSRGFGS FRFPAGGQGG AGPSQGAGGG SGGSHFNEEE 800
DDLYG 805
Length:805
Mass (Da):89,236
Last modified:July 19, 2004 - v1
Checksum:i52DF6D8968F977EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074716 mRNA. Translation: AAH74716.1.
RefSeqiNP_001005677.1. NM_001005677.1.
UniGeneiStr.1287.

Genome annotation databases

GeneIDi448177.
KEGGixtr:448177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074716 mRNA. Translation: AAH74716.1 .
RefSeqi NP_001005677.1. NM_001005677.1.
UniGenei Str.1287.

3D structure databases

ProteinModelPortali Q6GL04.
SMRi Q6GL04. Positions 21-763.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000054726.

Proteomic databases

PaxDbi Q6GL04.
PRIDEi Q6GL04.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448177.
KEGGi xtr:448177.

Organism-specific databases

CTDi 7415.
Xenbasei XB-GENE-969573. vcp.

Phylogenomic databases

eggNOGi COG0464.
HOGENOMi HOG000223224.
InParanoidi Q6GL04.
KOi K13525.

Family and domain databases

Gene3Di 3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
IPR015415. Vps4_C.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
PF09336. Vps4_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsi TIGR01243. CDC48. 1 hit.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tail bud.

Entry informationi

Entry nameiTERA_XENTR
AccessioniPrimary (citable) accession number: Q6GL04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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