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Q6GKH9 (BUTA_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diacetyl reductase [(S)-acetoin forming]
EC=1.1.1.304
Alternative name(s):
Acetoin(diacetyl) reductase
Short name=AR
Meso-2,3-butanediol dehydrogenase
Gene names
Name:butA
Ordered Locus Names:SAR0129
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH By similarity.

Catalytic activity

(S)-acetoin + NAD+ = diacetyl + NADH.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processacetoin catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functiondiacetyl reductase ((S)-acetoin forming) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Diacetyl reductase [(S)-acetoin forming]
PRO_0000054542

Regions

Nucleotide binding8 – 3225NAD By similarity

Sites

Active site1541Proton acceptor By similarity
Active site1581 By similarity
Binding site1411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GKH9 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 114AFD0DC5D780CF

FASTA25827,216
        10         20         30         40         50         60 
MTNNKVALVT GGAQGIGFKI AERLVEDGFK VAVVDFNEEG AKAAALKLSS DGTKAIAIKA 

        70         80         90        100        110        120 
DVSNRDDVFN AVRQTAAQFG DFHVMVNNAG LGPTTPIDTI TEEQFKTVYG VNVAGVLWGI 

       130        140        150        160        170        180 
QAAHEQFKKF NHGGKIINAT SQAGVEGNPG LSLYCSTKFA VRGLTQVAAQ DLASEGITVN 

       190        200        210        220        230        240 
AFAPGIVQTP MMESIAVATA EEAGKPEAWG WEQFTSQIAL GRVSQPEDVS NVVSFLAGKD 

       250 
SDYITGQTII VDGGMRFR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571856 Genomic DNA. Translation: CAG39155.1.
RefSeqYP_039593.1. NC_002952.2.

3D structure databases

ProteinModelPortalQ6GKH9.
SMRQ6GKH9. Positions 4-257.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6GKH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000021161; EBSTAP00000020497; EBSTAG00000021160.
GeneID2860305.
GenomeReviewsGene locus SAR0129 in contig BX571856_GR.
KEGGsar:SAR0129.
PATRIC19543754. VBIStaAur71814_0129.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1028.
GeneTreeEBGT00050000023864.
HOGENOMHBG750976.
OMAVAACVAY.
ProtClustDBPRK08643.

Enzyme and pathway databases

BioCycSAUR282458:SAR0129-MONOMER.

Family and domain databases

InterProIPR014007. 23BDH.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK03366.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR02415. 23BDH. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUTA_STAAR
AccessionPrimary (citable) accession number: Q6GKH9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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