Reviewed, UniProtKB/Swiss-Prot Q6GKC1 (OAT1_STAAR)

Names and origin

Protein names

Recommended name:
    Ornithine aminotransferase 1
      Short name=OAT 1
    EC=2.6.1.13
Alternative name(s):
    Ornithine--oxo-acid aminotransferase 1

Gene names

Name:	rocD1
Ordered Locus Names:	SAR0186

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of ornithine to glutamate semialdehyde By similarity.
Catalytic activity	L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-ornithine: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: InterPro proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ornithine-oxo-acid transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Ornithine aminotransferase 1		PRO_0000112786
Amino acid modifications
	Modified residue	252	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GKC1-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 125653621113B74C	FASTA	394	43,042
	10 20 30 40 50 60 MNSIIELTDY YSSNNYAPLK LVITEGKGGK VWDTDGKQYI DCISGFSVAN QGHCHPTIVK 70 80 90 100 110 120 AMTEQASKLS IISRVLYSDN LGKWEEKICH LAKKDKVLPL NSGTEAVEAA IKIARKWGSD 130 140 150 160 170 180 VKGITDGQVE IIAMNNNFHG RTLGSLSLSN HDAYKSGFHP LLQGTKTVDF GDIEQLTQAI 190 200 210 220 230 240 SPNTAAIILE PIQGEGGVNI PPKGYIQAVR QLCDKHQILL IADEIQVGLG RTGKWFAMEW 250 260 270 280 290 300 EQVVPDIYIL GKALGGGLYP VSAVLANNDV MRVLTPGTHG STFGGNPLAI AISTAALDVL 310 320 330 340 350 360 KDEQLVERSE RLGSFLLKAL LQLKHPSIKE IRGRGLFIGI ELNTDAAPFV EQLIKRGILC 370 380 390 KDTHRTIIRL SPPLVIDKEE INQIVAAFQD VFKN

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX571856 Genomic DNA. Translation: CAG39213.1.
RefSeq	YP_039651.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2860210.
GenomeReviews	Gene locus SAR0186 in contig BX571856_GR.
KEGG	sar:SAR0186.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6GKC1.
OMA	Q6GKC1. TICAANG.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR0186-MON.
Family and domain databases
HAMAP	MF_01689. [Tree]
InterPro	IPR005814. Aminotrans_3. IPR004636. ArgD_aminotrans. IPR010164. Orn_aminotrans. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF18. Orn_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00707. argD. 1 hit. TIGR01885. Orn_aminotrans. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OAT1_STAAR

Accession

Primary (citable) accession number: Q6GKC1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)