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Protein

Ribitol-5-phosphate cytidylyltransferase 1

Gene

tarI1

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.UniRule annotation

Catalytic activityi

CTP + D-ribitol 5-phosphate = diphosphate + CDP-ribitol.UniRule annotation

Pathwayi: poly(ribitol phosphate) teichoic acid biosynthesis

This protein is involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway poly(ribitol phosphate) teichoic acid biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei14Transition state stabilizerUniRule annotation1
Sitei22Transition state stabilizerUniRule annotation1
Binding sitei112CTPUniRule annotation1
Sitei160Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1
Sitei217Positions ribitol 5-phosphate for the nucleophilic attackUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 10CTPUniRule annotation4
Nucleotide bindingi81 – 87CTPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Cell wall biogenesis/degradation, Teichoic acid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00790.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribitol-5-phosphate cytidylyltransferase 1UniRule annotation (EC:2.7.7.40UniRule annotation)
Gene namesi
Name:tarI1UniRule annotation
Ordered Locus Names:SAR0252
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000756201 – 238Ribitol-5-phosphate cytidylyltransferase 1Add BLAST238

Structurei

3D structure databases

ProteinModelPortaliQ6GK57.
SMRiQ6GK57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218563.
KOiK00991.
OMAiPQVFDAD.

Family and domain databases

CDDicd02516. CDP-ME_synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02068. TarI. 1 hit.
InterProiIPR001228. IspD.
IPR018294. ISPD_synthase_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01128. IspD. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS01295. ISPD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GK57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYAGILAGG IGSRMGNVPL PKQFLDLDNK PILIHTLEKF ILINDFEKII
60 70 80 90 100
IATPQQWMTH TKDTLRKFKI SDERIEVIQG GSDRNDTIMN IVKHIESTNG
110 120 130 140 150
INDDDVIVTH DAVRPFLTHR IIKENIQAAL EYGAVDTVID AIDTIVTSKD
160 170 180 190 200
NQTIDAIPVR NEMYQGQTPQ SFNINLLKES YAQLSDEQKS ILSDACKIIV
210 220 230
ETNKPVRLVK GELYNIKVTT PYDLKVANAI IRGGIADD
Length:238
Mass (Da):26,657
Last modified:July 19, 2004 - v1
Checksum:iB19F7EA82D847A0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39278.1.
RefSeqiWP_000872486.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39278; CAG39278; SAR0252.
GeneIDi28379428.
KEGGisar:SAR0252.
PATRICi19544003. VBIStaAur71814_0253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39278.1.
RefSeqiWP_000872486.1. NC_002952.2.

3D structure databases

ProteinModelPortaliQ6GK57.
SMRiQ6GK57.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG39278; CAG39278; SAR0252.
GeneIDi28379428.
KEGGisar:SAR0252.
PATRICi19544003. VBIStaAur71814_0253.

Phylogenomic databases

HOGENOMiHOG000218563.
KOiK00991.
OMAiPQVFDAD.

Enzyme and pathway databases

UniPathwayiUPA00790.

Family and domain databases

CDDicd02516. CDP-ME_synthetase. 1 hit.
Gene3Di3.90.550.10. 1 hit.
HAMAPiMF_02068. TarI. 1 hit.
InterProiIPR001228. IspD.
IPR018294. ISPD_synthase_CS.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01128. IspD. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTARI1_STAAR
AccessioniPrimary (citable) accession number: Q6GK57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.