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Protein

ESAT-6 secretion machinery protein EssC

Gene

essC

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the ESAT-6 secretion system (Ess). Required for the secretion of EsxA.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi672 – 679ATPPROSITE-ProRule annotation8
Nucleotide bindingi1014 – 1021ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ESAT-6 secretion machinery protein EssCBy similarity
Gene namesi
Name:essCBy similarity
Ordered Locus Names:SAR0284
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229CytoplasmicBy similarityAdd BLAST229
Transmembranei230 – 252HelicalSequence analysisAdd BLAST23
Topological domaini253 – 256ExtracellularBy similarity4
Transmembranei257 – 279HelicalSequence analysisAdd BLAST23
Topological domaini280 – 1482CytoplasmicBy similarityAdd BLAST1203

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000983321 – 1482ESAT-6 secretion machinery protein EssCAdd BLAST1482

Structurei

3D structure databases

ProteinModelPortaliQ6GK24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini652 – 846FtsK 1PROSITE-ProRule annotationAdd BLAST195
Domaini997 – 1183FtsK 2PROSITE-ProRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the EssC family.Curated
Contains 2 FtsK domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000119940.
KOiK03466.
OMAiWEWMKWL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GK24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKLIIKYNK QLKMLNLRDG KTYTISEDER ADITLKSLGE VIHLEQNNQG
60 70 80 90 100
TWQANHTSIN KVLVRKGDLD DITLQLYTEA DYASFAYPSI QDTMTIGSNA
110 120 130 140 150
YDDMVIQSLM NAIIIKDFQS IQETQYVRIV HDKNTDVYIN YELQEQLTNK
160 170 180 190 200
AYIGDHIYVE GIWLEVQADG LNVLSQNTVA SSLIRLTQEM PHAQADDYNT
210 220 230 240 250
YHRSPRIIHR EPTDDIKIER PPQPIQKNNT VIWRSIIPPL VMIALTVVIF
260 270 280 290 300
LVRPIGIYIL MMIGMSTVTI VFGITTYFSE KKKYNKDVEK REKDYKAYLD
310 320 330 340 350
NKSKEINKAI KAQRFSLNYH YPTVAEIKDI VETKAPRIYE KTSHHHDFLH
360 370 380 390 400
YKLGIANVEK SFKLDYQEEE FNQRRDELFD DAKELYEFYT DVEQAPLIND
410 420 430 440 450
LNHGPIAYIG ARHLILEELE KMLIQLSTFH SYHDLEFLFV TREDEVETLK
460 470 480 490 500
WARWLPHMTL RGQNIRGFVY NQRTRDQILT SIYSMIKERI QAVRERSRSN
510 520 530 540 550
EQIIFTPQLV FVITDMSLII DHVILEYVNQ DLSEYGISLI FVEDVIESLP
560 570 580 590 600
EHVDTIIDIK SRTEGELITK EKELVQLKFT PENIDNVDKE YIARRLANLI
610 620 630 640 650
HVEHLKNAIP DSITFLEMYN VKEVDQLDVV NRWRQNETYK TMAVPLGVRG
660 670 680 690 700
KDDILSLNLH EKAHGPHGLV AGTTGSGKSE IIQSYILSLA INFHPHEVAF
710 720 730 740 750
LLIDYKGGGM ANLFKDLVHL VGTITNLDGD EAMRALTSIK AELRKRQRLF
760 770 780 790 800
GEHDVNHINQ YHKLFKEGVA TEPMPHLFII SDEFAELKSE QPDFMKELVS
810 820 830 840 850
TARIGRSLGI HLILATQKPS GVVDDQIWSN SKFKLALKVQ DRQDSNEILK
860 870 880 890 900
TPDAADITLP GRAYLQVGNN EIYELFQSAW SGATYDIEGD KLEVEDKTIY
910 920 930 940 950
MINDYGQLQA INKDLSGLED EETKENQTEL EAVIDHIESI TTRLEIEEVK
960 970 980 990 1000
RPWLPPLPEN VYQEDLVETD FRKLWSDDAK EVELTLGLKD VPEEQYQGPM
1010 1020 1030 1040 1050
VLQLKKAGHI ALIGSPGYGR TTFLHNIIFD VARHHRPDQA HMYLFDFGTN
1060 1070 1080 1090 1100
GLMPVTDIPH VADYFTVDQE DKIAKAIRKI HDIISERKRL LSQERVVNIE
1110 1120 1130 1140 1150
QYNKETGNSI PNVFLIIDNY DTVKESPFME EYEEMMSKVT REGLALGVYI
1160 1170 1180 1190 1200
ILSGSRSSAI KSAIFTNIKT RVALYLFENN ELTNIIGSYK KGVKDVKGRA
1210 1220 1230 1240 1250
AINDDNFTQF QIAQPFELAE GQTYNERIKN EVAQMKEFYV GDYPKHIPMM
1260 1270 1280 1290 1300
PDKVFMEDIR EAYDLEKIIH EEHKLPLGLD FEDVELVSLD LTSSSIVTAI
1310 1320 1330 1340 1350
KPTEMEKMND VIMSSLSVYS KNQFVILVDA EDNMSQYSED VTSYYSAPSD
1360 1370 1380 1390 1400
LSNIRLGFKQ EIEARKNGEK SIEECKIVFI NNIKRFNQLT GMTEDEIRVL
1410 1420 1430 1440 1450
FNEGQKVNII IIASGLYSDT IGAFDRESKM MVRTINQALI SHKISEQEFI
1460 1470 1480
RVKDRFGEPE LKVGEMYYIN NQEYQKIKLM EG
Length:1,482
Mass (Da):170,971
Last modified:July 19, 2004 - v1
Checksum:iFF878C6DAD6CE5FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39311.1.
RefSeqiWP_000549309.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39311; CAG39311; SAR0284.
KEGGisar:SAR0284.
PATRICi19544073. VBIStaAur71814_0288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39311.1.
RefSeqiWP_000549309.1. NC_002952.2.

3D structure databases

ProteinModelPortaliQ6GK24.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG39311; CAG39311; SAR0284.
KEGGisar:SAR0284.
PATRICi19544073. VBIStaAur71814_0288.

Phylogenomic databases

HOGENOMiHOG000119940.
KOiK03466.
OMAiWEWMKWL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR023839. Firmicutes_EssC_C.
IPR022206. Firmicutes_EssC_N.
IPR002543. FtsK_dom.
IPR027417. P-loop_NTPase.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PfamiPF01580. FtsK_SpoIIIE. 2 hits.
PF12538. FtsK_SpoIIIE_N. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR03928. T7_EssCb_Firm. 1 hit.
PROSITEiPS50901. FTSK. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiESSC_STAAR
AccessioniPrimary (citable) accession number: Q6GK24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

This strain lacks esxB and esxC.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.