Q6GJZ6 (LIP2_STAAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipase 2
EC=3.1.1.3

Alternative name(s):
Glycerol ester hydrolase 2

Gene names

Name:	lip2
Synonyms:	geh
Ordered Locus Names:	SAR0317

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 37	37	Potential
	Propeptide	38 – 296	259	By similarity		PRO_0000045192
	Chain	297 – 691	395	Lipase 2		PRO_0000045193
Sites
	Active site	413	1	Charge relay system By similarity
	Active site	646	1	Charge relay system By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GJZ6 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 004B27884B347E62	FASTA	691	76,691
	10 20 30 40 50 60 MLRGQEERKY SIRKYSIGVV SVLAATMFVV TSHEAQASEK IPTTNAAAQK ETLNQPGEQG 70 80 90 100 110 120 NAITSHQMQS GKQLDDMHKE NGKSGTVTEG KDMLQSSKHQ STQNSKIIRT QNDNQVKQDS 130 140 150 160 170 180 ERQGSKQSHQ NNATNKTERQ NDQIQNTHHA ERNGSQSTTS QSNDVDKSQP SIPAQKVIPN 190 200 210 220 230 240 HDKAAPTSTT PPSNDKTAPK STKEQDATTD KHPNQQDTHQ PAHQIIDAKQ DDNVHQSNQK 250 260 270 280 290 300 PQVGDLSKHI DGQNSPEKPT DKNTDNKQLI KDALQAPKTR STTNAAADAK KVRPLKANQV 310 320 330 340 350 360 QPLNKYPVVF VHGFLGLVGD NAPALYPNYW GGNKYKVIEE LRKQGYNVHQ ASVSAFGSNY 370 380 390 400 410 420 DRAVELYYYI KGGRVDYGAA HAAKYGHERY GKTYKGIMPN WEPGKKVHLV GHSMGGQTIR 430 440 450 460 470 480 LMEEFLRNGN KEEIAYHKAH GGEISPLFTG GHNNMVASIT TLATPHNGSQ AADKFGNTEA 490 500 510 520 530 540 VRKIMFALNR FMGNKYSNID LGLTQWGFKQ LPNESYIDYI KRVSKSKIWT SDDNAAYDLT 550 560 570 580 590 600 LNGSAKLNNM TSMNPNITYT TYTGVSSHTG PLGYENPDLG TFFLMDTTSR IIGHDAREEW 610 620 630 640 650 660 RKNDGVVPVI SSLHPSNQPF VNVTNDEPAT RRGIWQVKPI IQGWDHVDFI GVDFLDFKRK 670 680 690 GAELANFYTG IINDLLRVEA TESKGTQLKA S

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MRSA252.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG39341.1.
RefSeq	YP_039776.1. NC_002952.2.
3D structure databases
ProteinModelPortal	Q6GJZ6.
SMR	Q6GJZ6. Positions 296-683.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GJZ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000020388; EBSTAP00000019724; EBSTAG00000020387.
GeneID	2859913.
GenomeReviews	Gene locus SAR0317 in contig BX571856_GR.
KEGG	sar:SAR0317.
PATRIC	19544141. VBIStaAur71814_0321.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1075.
GeneTree	EBGT00050000023709.
HOGENOM	HBG694146.
OMA	ETINRIG.
ProtClustDB	CLSK2752181.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR0317-MONOMER.
Family and domain databases
InterPro	IPR005877. Gpos_YSIRK. [Graphical view]
KO	K01046.
Pfam	PF04650. YSIRK_signal. 1 hit. [Graphical view]
TIGRFAMs	TIGR01168. YSIRK_signal. 1 hit.
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP2_STAAR

Accession

Primary (citable) accession number: Q6GJZ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program