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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSAUR282458:G1G3O-485-MONOMER

Protein family/group databases

CAZyiCBM50 Carbohydrate-Binding Module Family 50

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SAR0464
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023162426 – 334N-acetylmuramoyl-L-alanine amidase sle1Add BLAST309

Structurei

3D structure databases

ProteinModelPortaliQ6GJK9
SMRiQ6GJK9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 70LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini91 – 134LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini158 – 201LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini210 – 334Peptidase C51PROSITE-ProRule annotationAdd BLAST125

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000279823
KOiK22409
OMAiNTPVFNH

Family and domain databases

CDDicd00118 LysM, 3 hits
Gene3Di3.10.350.10, 3 hits
InterProiView protein in InterPro
IPR007921 CHAP_dom
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF05257 CHAP, 1 hit
PF01476 LysM, 3 hits
SMARTiView protein in SMART
SM00257 LysM, 3 hits
PROSITEiView protein in PROSITE
PS50911 CHAP, 1 hit
PS51782 LYSM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GJK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK
60 70 80 90 100
LKSLNNLTSN LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS
110 120 130 140 150
LSLIASKYGT TYQNIMRLNG LNNFFIYPGQ KLKVSGTASS SNSTSNSSRP
160 170 180 190 200
STNSSGGSYY TVQAGDSLSL IASKYGTTYQ NIMRLNGLNN FFIYPGQKLK
210 220 230 240 250
VTGNASTNSG STTTTNRGYN TPVFNHQNLY TWGQCTYHVF NRRAEIGKGI
260 270 280 290 300
STYWWNANNW DNAAAADGYT IDNRPTVGSI AQTDVGYYGH VMFVERVNND
310 320 330
GSILVSEMNY SAAPGILTYR TVPAYQVNNY RYIH
Length:334
Mass (Da):36,024
Last modified:July 19, 2004 - v1
Checksum:iA168D7E94420E85A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG39485.1
RefSeqiWP_001170274.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG39485; CAG39485; SAR0464
KEGGisar:SAR0464

Similar proteinsi

Entry informationi

Entry nameiSLE1_STAAR
AccessioniPrimary (citable) accession number: Q6GJK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health