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Protein

Protein-arginine kinase

Gene

mcsB

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of arginine residues in proteins.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-arginine = ADP + a [protein]-N(omega)-phospho-L-arginine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821ATPUniRule annotation
Binding sitei115 – 1151ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 285ATPUniRule annotation
Nucleotide bindingi166 – 1705ATPUniRule annotation
Nucleotide bindingi197 – 2026ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-544-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine kinaseUniRule annotation (EC:2.7.14.1UniRule annotation)
Gene namesi
Name:mcsBUniRule annotation
Ordered Locus Names:SAR0527
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Protein-arginine kinasePRO_0000212031Add
BLAST

Proteomic databases

PRIDEiQ6GJE5.

Structurei

3D structure databases

ProteinModelPortaliQ6GJE5.
SMRiQ6GJE5. Positions 18-249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 244224Phosphagen kinase C-terminalUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.UniRule annotation
Contains 1 phosphagen kinase C-terminal domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000082112.
KOiK19405.
OMAiIIMQERV.
OrthoDBiEOG6NKR1D.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GJE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHNIHDNIS QWMKSNEETP IVMSSRIRLA RNLENHVHPL MYATENDGFR
60 70 80 90 100
VINEVQDALP NFELMRLDQM DQQSKMKMVA KHLISPELIK QPAAAVLVND
110 120 130 140 150
DESLSVMINE EDHIRIQAMG TDTTLQALYN QASSIDDELD RSLDISYDEQ
160 170 180 190 200
LGYLTTCPTN IGTGMRASVM LHLPGLSIMK RMTRIAQTIN RFGYTIRGIY
210 220 230 240 250
GEGSQVYGHT YQVSNQLTLG KSELEIIETL TEVVNQIIHE EKQIRQKLDT
260 270 280 290 300
YNQLETQDRV FRSLGILQNC RMITMEEASY RLSEVKLGID LNYIELQNFK
310 320 330
FNELMVAIQS PFLLDEEDDK SVKEKRADIL REHIK
Length:335
Mass (Da):38,610
Last modified:July 19, 2004 - v1
Checksum:iFB1B26912A0A64BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39549.1.
RefSeqiWP_000149503.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39549; CAG39549; SAR0527.
KEGGisar:SAR0527.
PATRICi19544606. VBIStaAur71814_0536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39549.1.
RefSeqiWP_000149503.1. NC_002952.2.

3D structure databases

ProteinModelPortaliQ6GJE5.
SMRiQ6GJE5. Positions 18-249.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6GJE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG39549; CAG39549; SAR0527.
KEGGisar:SAR0527.
PATRICi19544606. VBIStaAur71814_0536.

Phylogenomic databases

HOGENOMiHOG000082112.
KOiK19405.
OMAiIIMQERV.
OrthoDBiEOG6NKR1D.

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-544-MONOMER.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
HAMAPiMF_00602. Prot_Arg_kinase.
InterProiIPR023660. Arg_Kinase.
IPR000749. ATP-guanido_PTrfase.
IPR022415. ATP-guanido_PTrfase_AS.
IPR022414. ATP-guanido_PTrfase_cat.
IPR014746. Gln_synth/guanido_kin_cat_dom.
[Graphical view]
PANTHERiPTHR11547. PTHR11547. 2 hits.
PfamiPF00217. ATP-gua_Ptrans. 1 hit.
[Graphical view]
PROSITEiPS00112. PHOSPHAGEN_KINASE. 1 hit.
PS51510. PHOSPHAGEN_KINASE_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiMCSB_STAAR
AccessioniPrimary (citable) accession number: Q6GJE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.