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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:SAR0594
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791431 – 328Phosphate acetyltransferaseAdd BLAST328

Structurei

Secondary structure

1328
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 12Combined sources12
Beta strandi17 – 21Combined sources5
Helixi27 – 37Combined sources11
Beta strandi39 – 48Combined sources10
Helixi50 – 59Combined sources10
Beta strandi67 – 70Combined sources4
Helixi72 – 74Combined sources3
Helixi78 – 88Combined sources11
Turni89 – 91Combined sources3
Helixi95 – 101Combined sources7
Helixi105 – 114Combined sources10
Beta strandi119 – 123Combined sources5
Helixi133 – 139Combined sources7
Beta strandi150 – 157Combined sources8
Beta strandi160 – 169Combined sources10
Helixi175 – 191Combined sources17
Beta strandi197 – 201Combined sources5
Beta strandi203 – 205Combined sources3
Helixi212 – 230Combined sources19
Beta strandi236 – 241Combined sources6
Helixi243 – 247Combined sources5
Helixi249 – 255Combined sources7
Beta strandi267 – 269Combined sources3
Helixi273 – 285Combined sources13
Beta strandi290 – 297Combined sources8
Beta strandi299 – 301Combined sources3
Beta strandi303 – 305Combined sources3
Helixi312 – 326Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E4RX-ray1.44A1-328[»]
ProteinModelPortaliQ6GJ80.
SMRiQ6GJ80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000053796.
KOiK00625.
OMAiGCSTEDV.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GJ80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLLNVLKD KLSGKNVKIV LPEGEDERVL TAATQLQATD YVTPIVLGDE
60 70 80 90 100
TKVQSLAQKL NLDISNIELI NPATSELKAE LVQSFVERRK GKTTEEQAQE
110 120 130 140 150
LLNNVNYFGT MLVYAGKADG LVSGAAHSTG DTVRPALQII KTKPGVSRTS
160 170 180 190 200
GIFFMIKGDE QYIFGDCAIN PELDSQGLAE IAVESAKSAL SFGMDPKVAM
210 220 230 240 250
LSFSTKGSAK SDDVTKVQEA VKLAQQKAEE EKLEAIIDGE FQFDAAIVPG
260 270 280 290 300
VAEKKAPGAK LQGDANVFVF PSLEAGNIGY KIAQRLGGYD AVGPVLQGLN
310 320
SPVNDLSRGC SIEDVYNLSF ITAAQALQ
Length:328
Mass (Da):35,015
Last modified:July 19, 2004 - v1
Checksum:i2F875831DD08C097
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39614.1.
RefSeqiWP_000774291.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39614; CAG39614; SAR0594.
KEGGisar:SAR0594.
PATRICi19544736. VBIStaAur71814_0601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39614.1.
RefSeqiWP_000774291.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E4RX-ray1.44A1-328[»]
ProteinModelPortaliQ6GJ80.
SMRiQ6GJ80.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG39614; CAG39614; SAR0594.
KEGGisar:SAR0594.
PATRICi19544736. VBIStaAur71814_0601.

Phylogenomic databases

HOGENOMiHOG000053796.
KOiK00625.
OMAiGCSTEDV.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Family and domain databases

InterProiIPR012147. P_Ac_Bu_trans.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
[Graphical view]
PfamiPF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000428. P_Ac_trans. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTAS_STAAR
AccessioniPrimary (citable) accession number: Q6GJ80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.