Q6GJ34 (TAGA_STAAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative N-acetylmannosaminyltransferase
EC=2.4.1.187

Alternative name(s):
Major teichoic acid biosynthesis protein A
N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase
UDP-N-acetylmannosamine transferase

Gene names

Name:	tagA
Ordered Locus Names:	SAR0646

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, a key lipid intermediate in the de novo synthesis of teichoic acid Potential.
Catalytic activity	UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol.
Pathway	Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis.
Subcellular location	Secreted › cell wall By similarity.
Sequence similarities	Belongs to the glycosyltransferase 26 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Teichoic acid biosynthesis
Cellular component	Secreted
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Putative N-acetylmannosaminyltransferase		PRO_0000208444

Sequences

	Sequence		Length	Mass (Da)
	Q6GJ34 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 06EF3B87AC6660B5	FASTA	254	29,119
	10 20 30 40 50 60 MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP EIVNYATTHQ 70 80 90 100 110 120 AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM DECLKIAHVN HQKVFLLGAT 130 140 150 160 170 180 NEVGEAAQYA LQQRYPNISF AHHHGYIDLE DETVVKRIEL FKPDYIFVGM GFPKQEEWIM 190 200 210 220 230 240 THENQFESKV MMGVGGSLEV FAGAKKRAPY IFRKLNIEWI YRALIDWKRI GRLKSIPIFM 250 YKIAKAKRKI KKAK

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MRSA252.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG39663.1.
RefSeq	YP_040088.1. NC_002952.2.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GJ34.
Protein family/group databases
CAZy	GT26. Glycosyltransferase Family 26.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000020352; EBSTAP00000019688; EBSTAG00000020351.
GeneID	2859514.
GenomeReviews	Gene locus SAR0646 in contig BX571856_GR.
KEGG	sar:SAR0646.
PATRIC	19544841. VBIStaAur71814_0653.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1922.
GeneTree	EBGT00050000025549.
HOGENOM	HBG685240.
OMA	ENFIQNN.
ProtClustDB	CLSK884777.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR0646-MONOMER.
Family and domain databases
InterPro	IPR004629. WecB_TagA_CpsF. [Graphical view]
KO	K05946.
Pfam	PF03808. Glyco_tran_WecB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00696. WecB_tagA_cpsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TAGA_STAAR

Accession

Primary (citable) accession number: Q6GJ34

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program