SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6GIZ3

- ARSC_STAAR

UniProt

Q6GIZ3 - ARSC_STAAR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein ArsC

Gene
arsC, SAR0692
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activity By similarity
Active sitei82 – 821Nucleophile; for reductase activity By similarity
Active sitei89 – 891Nucleophile; for reductase activity By similarity

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsC
Alternative name(s):
Arsenate reductase (EC:1.20.4.-)
Arsenical pump modifier
Low molecular weight protein-tyrosine-phosphatase (EC:3.1.3.48)
Gene namesi
Name:arsC
Ordered Locus Names:SAR0692
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 131131Protein ArsCUniRule annotationPRO_0000162525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi10 ↔ 82Redox-active; alternate By similarity
Disulfide bondi82 ↔ 89Redox-active; alternate By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi282458.SAR0692.

Structurei

3D structure databases

ProteinModelPortaliQ6GIZ3.
SMRiQ6GIZ3. Positions 2-131.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273093.
KOiK03741.
OMAiHNLPITR.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GIZ3-1 [UniParc]FASTAAdd to Basket

« Hide

MDKKTIYFIC TGNSCRSQMA EGWGKEILGE GWNVYSAGIE THGVNPKAIE    50
AMKEVDIDIS NHTSDLIDND ILKQSDLVVT LCSDADNNCP ILPPNVKKEH 100
WGFDDPAGKE WSEFQRVRDE IKLAIEKFKL R 131
Length:131
Mass (Da):14,813
Last modified:July 19, 2004 - v1
Checksum:i03871148DC433A18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39708.1.
RefSeqiYP_040129.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39708; CAG39708; SAR0692.
GeneIDi2859866.
KEGGisar:SAR0692.
PATRICi19544931. VBIStaAur71814_0698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39708.1 .
RefSeqi YP_040129.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GIZ3.
SMRi Q6GIZ3. Positions 2-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR0692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG39708 ; CAG39708 ; SAR0692 .
GeneIDi 2859866.
KEGGi sar:SAR0692.
PATRICi 19544931. VBIStaAur71814_0698.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273093.
KOi K03741.
OMAi HNLPITR.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-700-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiARSC_STAAR
AccessioniPrimary (citable) accession number: Q6GIZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi