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Q6GIL8

- G3P1_STAAR

UniProt

Q6GIL8 - G3P1_STAAR

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Protein
Glyceraldehyde-3-phosphate dehydrogenase 1
Gene
gapA1, gap, gapA, SAR0828
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Active sitei151 – 1511Nucleophile By similarity
Sitei178 – 1781Activates thiol group during catalysis By similarity
Binding sitei181 – 1811Glyceraldehyde 3-phosphate By similarity
Binding sitei198 – 1981Glyceraldehyde 3-phosphate By similarity
Binding sitei234 – 2341Glyceraldehyde 3-phosphate By similarity
Binding sitei316 – 3161NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 132NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. NADP binding Source: InterPro
  3. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. glucose metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-831-MONOMER.
UniPathwayiUPA00109; UER00184.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenase 1 (EC:1.2.1.12)
Short name:
GAPDH 1
Gene namesi
Name:gapA1
Synonyms:gap, gapA
Ordered Locus Names:SAR0828
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336Glyceraldehyde-3-phosphate dehydrogenase 1
PRO_0000145685Add
BLAST

Proteomic databases

PRIDEiQ6GIL8.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi282458.SAR0828.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 86
Helixi12 – 2211
Beta strandi27 – 337
Helixi38 – 469
Turni49 – 513
Beta strandi58 – 614
Beta strandi64 – 674
Beta strandi70 – 756
Helixi80 – 823
Turni85 – 895
Beta strandi91 – 955
Beta strandi97 – 993
Helixi103 – 1119
Beta strandi115 – 1217
Beta strandi124 – 1263
Turni132 – 1343
Helixi136 – 1383
Beta strandi144 – 1474
Helixi151 – 16717
Beta strandi169 – 17911
Beta strandi186 – 1883
Turni196 – 1994
Helixi202 – 2043
Beta strandi207 – 2104
Turni213 – 2164
Helixi217 – 2193
Helixi222 – 2243
Beta strandi227 – 23610
Beta strandi241 – 25313
Helixi256 – 26510
Beta strandi269 – 2746
Helixi280 – 2834
Beta strandi289 – 2935
Helixi294 – 2963
Beta strandi298 – 3025
Beta strandi305 – 31410
Helixi318 – 33417

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HQ4X-ray2.20O/P/Q/R1-336[»]
3K73X-ray2.50O/P/Q/R1-336[»]
3K9QX-ray2.50O/P/Q/R1-336[»]
3KSDX-ray2.20O/P/Q/R1-336[»]
3KSZX-ray2.60O/P/Q/R1-336[»]
3KV3X-ray2.50O/P/Q/R1-336[»]
3L4SX-ray2.20O/P/Q/R1-336[»]
3L6OX-ray2.20O/P/Q/R1-336[»]
3LC1X-ray2.00O/P/Q/R1-336[»]
3LC2X-ray2.80O/P/Q/R1-336[»]
3LC7X-ray2.50O/P/Q/R1-336[»]
3LVFX-ray1.70O/P/Q/R1-336[»]
3VAZX-ray3.19A/B/O/P/Q/R1-336[»]
ProteinModelPortaliQ6GIL8.
SMRiQ6GIL8. Positions 1-336.

Miscellaneous databases

EvolutionaryTraceiQ6GIL8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni150 – 1523Glyceraldehyde 3-phosphate binding By similarity
Regioni211 – 2122Glyceraldehyde 3-phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0057.
HOGENOMiHOG000071678.
KOiK00134.
OMAiHQSIFDA.
OrthoDBiEOG66TG3S.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR10836. PTHR10836. 1 hit.
PfamiPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000149. GAP_DH. 1 hit.
PRINTSiPR00078. G3PDHDRGNASE.
SMARTiSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01534. GAPDH-I. 1 hit.
PROSITEiPS00071. GAPDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GIL8-1 [UniParc]FASTAAdd to Basket

« Hide

MAVKVAINGF GRIGRLAFRR IQEVEGLEVV AVNDLTDDDM LAHLLKYDTM    50
QGRFTGEVEV VDGGFRVNGK EVKSFSEPDA SKLPWKDLNI DVVLECTGFY 100
TDKDKAQAHI EAGAKKVLIS APATGDLKTI VFNTNHQELD GSETVVSGAS 150
CTTNSLAPVA KVLNDDFGLV EGLMTTIHAY TGDQNTQDAP HRKGDKRRAR 200
AAAENIIPNS TGAAKAIGKV IPEIDGKLDG GAQRVPVATG SLTELTVVLE 250
KQDVTVEQVN EAMKNASNES FGYTEDEIVS SDVVGMTYGS LFDATQTRVM 300
SVGDRQLVKV AAWYDNEMSY TAQLVRTLAY LAELSK 336
Length:336
Mass (Da):36,281
Last modified:July 19, 2004 - v1
Checksum:i37A6CEA9376779E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39837.1.
RefSeqiYP_040254.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39837; CAG39837; SAR0828.
GeneIDi2860688.
KEGGisar:SAR0828.
PATRICi19545193. VBIStaAur71814_0829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39837.1 .
RefSeqi YP_040254.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HQ4 X-ray 2.20 O/P/Q/R 1-336 [» ]
3K73 X-ray 2.50 O/P/Q/R 1-336 [» ]
3K9Q X-ray 2.50 O/P/Q/R 1-336 [» ]
3KSD X-ray 2.20 O/P/Q/R 1-336 [» ]
3KSZ X-ray 2.60 O/P/Q/R 1-336 [» ]
3KV3 X-ray 2.50 O/P/Q/R 1-336 [» ]
3L4S X-ray 2.20 O/P/Q/R 1-336 [» ]
3L6O X-ray 2.20 O/P/Q/R 1-336 [» ]
3LC1 X-ray 2.00 O/P/Q/R 1-336 [» ]
3LC2 X-ray 2.80 O/P/Q/R 1-336 [» ]
3LC7 X-ray 2.50 O/P/Q/R 1-336 [» ]
3LVF X-ray 1.70 O/P/Q/R 1-336 [» ]
3VAZ X-ray 3.19 A/B/O/P/Q/R 1-336 [» ]
ProteinModelPortali Q6GIL8.
SMRi Q6GIL8. Positions 1-336.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR0828.

Proteomic databases

PRIDEi Q6GIL8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG39837 ; CAG39837 ; SAR0828 .
GeneIDi 2860688.
KEGGi sar:SAR0828.
PATRICi 19545193. VBIStaAur71814_0829.

Phylogenomic databases

eggNOGi COG0057.
HOGENOMi HOG000071678.
KOi K00134.
OMAi HQSIFDA.
OrthoDBi EOG66TG3S.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00184 .
BioCyci SAUR282458:GJA5-831-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q6GIL8.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR10836. PTHR10836. 1 hit.
Pfami PF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000149. GAP_DH. 1 hit.
PRINTSi PR00078. G3PDHDRGNASE.
SMARTi SM00846. Gp_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01534. GAPDH-I. 1 hit.
PROSITEi PS00071. GAPDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiG3P1_STAAR
AccessioniPrimary (citable) accession number: Q6GIL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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