Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6GIL8

- G3P1_STAAR

UniProt

Q6GIL8 - G3P1_STAAR

Protein

Glyceraldehyde-3-phosphate dehydrogenase 1

Gene

gapA1

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341NADBy similarity
    Active sitei151 – 1511NucleophilePROSITE-ProRule annotation
    Sitei178 – 1781Activates thiol group during catalysisBy similarity
    Binding sitei181 – 1811Glyceraldehyde 3-phosphateBy similarity
    Binding sitei198 – 1981Glyceraldehyde 3-phosphateBy similarity
    Binding sitei234 – 2341Glyceraldehyde 3-phosphateBy similarity
    Binding sitei316 – 3161NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 132NADBy similarity

    GO - Molecular functioni

    1. glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro
    3. NADP binding Source: InterPro

    GO - Biological processi

    1. glucose metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSAUR282458:GJA5-831-MONOMER.
    UniPathwayiUPA00109; UER00184.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyceraldehyde-3-phosphate dehydrogenase 1 (EC:1.2.1.12)
    Short name:
    GAPDH 1
    Gene namesi
    Name:gapA1
    Synonyms:gap, gapA
    Ordered Locus Names:SAR0828
    OrganismiStaphylococcus aureus (strain MRSA252)
    Taxonomic identifieri282458 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000596: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336Glyceraldehyde-3-phosphate dehydrogenase 1PRO_0000145685Add
    BLAST

    Proteomic databases

    PRIDEiQ6GIL8.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi282458.SAR0828.

    Structurei

    Secondary structure

    1
    336
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 86
    Helixi12 – 2211
    Beta strandi27 – 337
    Helixi38 – 469
    Turni49 – 513
    Beta strandi58 – 614
    Beta strandi64 – 674
    Beta strandi70 – 756
    Helixi80 – 823
    Turni85 – 895
    Beta strandi91 – 955
    Beta strandi97 – 993
    Helixi103 – 1119
    Beta strandi115 – 1217
    Beta strandi124 – 1263
    Turni132 – 1343
    Helixi136 – 1383
    Beta strandi144 – 1474
    Helixi151 – 16717
    Beta strandi169 – 17911
    Beta strandi186 – 1883
    Turni196 – 1994
    Helixi202 – 2043
    Beta strandi207 – 2104
    Turni213 – 2164
    Helixi217 – 2193
    Helixi222 – 2243
    Beta strandi227 – 23610
    Beta strandi241 – 25313
    Helixi256 – 26510
    Beta strandi269 – 2746
    Helixi280 – 2834
    Beta strandi289 – 2935
    Helixi294 – 2963
    Beta strandi298 – 3025
    Beta strandi305 – 31410
    Helixi318 – 33417

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HQ4X-ray2.20O/P/Q/R1-336[»]
    3K73X-ray2.50O/P/Q/R1-336[»]
    3K9QX-ray2.50O/P/Q/R1-336[»]
    3KSDX-ray2.20O/P/Q/R1-336[»]
    3KSZX-ray2.60O/P/Q/R1-336[»]
    3KV3X-ray2.50O/P/Q/R1-336[»]
    3L4SX-ray2.20O/P/Q/R1-336[»]
    3L6OX-ray2.20O/P/Q/R1-336[»]
    3LC1X-ray2.00O/P/Q/R1-336[»]
    3LC2X-ray2.80O/P/Q/R1-336[»]
    3LC7X-ray2.50O/P/Q/R1-336[»]
    3LVFX-ray1.70O/P/Q/R1-336[»]
    3VAZX-ray3.19A/B/O/P/Q/R1-336[»]
    ProteinModelPortaliQ6GIL8.
    SMRiQ6GIL8. Positions 1-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6GIL8.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni150 – 1523Glyceraldehyde 3-phosphate bindingBy similarity
    Regioni211 – 2122Glyceraldehyde 3-phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0057.
    HOGENOMiHOG000071678.
    KOiK00134.
    OMAiHQSIFDA.
    OrthoDBiEOG66TG3S.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006424. Glyceraldehyde-3-P_DH_1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR10836. PTHR10836. 1 hit.
    PfamiPF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000149. GAP_DH. 1 hit.
    PRINTSiPR00078. G3PDHDRGNASE.
    SMARTiSM00846. Gp_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01534. GAPDH-I. 1 hit.
    PROSITEiPS00071. GAPDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GIL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVKVAINGF GRIGRLAFRR IQEVEGLEVV AVNDLTDDDM LAHLLKYDTM    50
    QGRFTGEVEV VDGGFRVNGK EVKSFSEPDA SKLPWKDLNI DVVLECTGFY 100
    TDKDKAQAHI EAGAKKVLIS APATGDLKTI VFNTNHQELD GSETVVSGAS 150
    CTTNSLAPVA KVLNDDFGLV EGLMTTIHAY TGDQNTQDAP HRKGDKRRAR 200
    AAAENIIPNS TGAAKAIGKV IPEIDGKLDG GAQRVPVATG SLTELTVVLE 250
    KQDVTVEQVN EAMKNASNES FGYTEDEIVS SDVVGMTYGS LFDATQTRVM 300
    SVGDRQLVKV AAWYDNEMSY TAQLVRTLAY LAELSK 336
    Length:336
    Mass (Da):36,281
    Last modified:July 19, 2004 - v1
    Checksum:i37A6CEA9376779E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG39837.1.
    RefSeqiYP_040254.1. NC_002952.2.

    Genome annotation databases

    EnsemblBacteriaiCAG39837; CAG39837; SAR0828.
    GeneIDi2860688.
    KEGGisar:SAR0828.
    PATRICi19545193. VBIStaAur71814_0829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG39837.1 .
    RefSeqi YP_040254.1. NC_002952.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HQ4 X-ray 2.20 O/P/Q/R 1-336 [» ]
    3K73 X-ray 2.50 O/P/Q/R 1-336 [» ]
    3K9Q X-ray 2.50 O/P/Q/R 1-336 [» ]
    3KSD X-ray 2.20 O/P/Q/R 1-336 [» ]
    3KSZ X-ray 2.60 O/P/Q/R 1-336 [» ]
    3KV3 X-ray 2.50 O/P/Q/R 1-336 [» ]
    3L4S X-ray 2.20 O/P/Q/R 1-336 [» ]
    3L6O X-ray 2.20 O/P/Q/R 1-336 [» ]
    3LC1 X-ray 2.00 O/P/Q/R 1-336 [» ]
    3LC2 X-ray 2.80 O/P/Q/R 1-336 [» ]
    3LC7 X-ray 2.50 O/P/Q/R 1-336 [» ]
    3LVF X-ray 1.70 O/P/Q/R 1-336 [» ]
    3VAZ X-ray 3.19 A/B/O/P/Q/R 1-336 [» ]
    ProteinModelPortali Q6GIL8.
    SMRi Q6GIL8. Positions 1-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282458.SAR0828.

    Proteomic databases

    PRIDEi Q6GIL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG39837 ; CAG39837 ; SAR0828 .
    GeneIDi 2860688.
    KEGGi sar:SAR0828.
    PATRICi 19545193. VBIStaAur71814_0829.

    Phylogenomic databases

    eggNOGi COG0057.
    HOGENOMi HOG000071678.
    KOi K00134.
    OMAi HQSIFDA.
    OrthoDBi EOG66TG3S.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00184 .
    BioCyci SAUR282458:GJA5-831-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q6GIL8.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR020831. GlycerAld/Erythrose_P_DH.
    IPR020830. GlycerAld_3-P_DH_AS.
    IPR020829. GlycerAld_3-P_DH_cat.
    IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
    IPR006424. Glyceraldehyde-3-P_DH_1.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10836. PTHR10836. 1 hit.
    Pfami PF02800. Gp_dh_C. 1 hit.
    PF00044. Gp_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000149. GAP_DH. 1 hit.
    PRINTSi PR00078. G3PDHDRGNASE.
    SMARTi SM00846. Gp_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01534. GAPDH-I. 1 hit.
    PROSITEi PS00071. GAPDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MRSA252.

    Entry informationi

    Entry nameiG3P1_STAAR
    AccessioniPrimary (citable) accession number: Q6GIL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3