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Q6GIL7

- PGK_STAAR

UniProt

Q6GIL7 - PGK_STAAR

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Protein
Phosphoglycerate kinase
Gene
pgk, SAR0829
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei156 – 1561Substrate By similarity
Binding sitei206 – 2061ATP By similarity
Binding sitei294 – 2941ATP; via carbonyl oxygen By similarity
Binding sitei325 – 3251ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi352 – 3554ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-832-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:SAR0829
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Phosphoglycerate kinaseUniRule annotation
PRO_0000146004Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi282458.SAR0829.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83
Beta strandi15 – 195
Beta strandi27 – 293
Helixi35 – 4915
Beta strandi53 – 575
Helixi66 – 683
Helixi70 – 723
Helixi75 – 8511
Beta strandi90 – 934
Beta strandi95 – 973
Helixi98 – 1058
Beta strandi112 – 1154
Helixi118 – 1225
Turni123 – 1319
Helixi133 – 1408
Beta strandi144 – 1485
Helixi151 – 1533
Turni159 – 1613
Helixi162 – 1654
Beta strandi170 – 1723
Helixi174 – 18815
Beta strandi192 – 1987
Helixi203 – 21311
Turni214 – 2163
Beta strandi218 – 2225
Helixi227 – 2337
Helixi245 – 2473
Helixi248 – 25710
Turni259 – 2613
Beta strandi266 – 27510
Beta strandi281 – 2844
Helixi285 – 2873
Beta strandi293 – 2975
Helixi299 – 3079
Turni308 – 3114
Beta strandi313 – 3197
Helixi327 – 3293
Helixi331 – 34212
Beta strandi344 – 3507
Helixi353 – 3619
Helixi365 – 3673
Beta strandi368 – 3714
Helixi375 – 3828
Helixi388 – 3914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DG5X-ray2.30A2-396[»]
ProteinModelPortaliQ6GIL7.
SMRiQ6GIL7. Positions 2-396.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate binding By similarity
Regioni59 – 624Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GIL7-1 [UniParc]FASTAAdd to Basket

« Hide

MAKKIVSDLD LKGKTVLVRA DFNVPLKDGE ITNDNRIVQA LPTIQYIIEQ    50
GGKIVLFSHL GKVKEESDKA KLTLRPVAED LSKKLDKEVV FVPETRGEKL 100
EAAIKDLKEG DVLLVENTRY EDLDGKKESK NDPELGKYWA SLGDVFVNDA 150
FGTAHREHAS NVGISTHLET AAGFLMDKEI KFIGGVVNDP HKPVVAILGG 200
AKVSDKINVI KNLVNIADKI IIGGGMAYTF LKAQGKEIGI SLLEEDKIDF 250
AKDLLEKHGD KIVLPVDTKV AKEFSNDAKI TVVPSDSIPA DQEGMDIGPN 300
TVKLFADELE GAHTVVWNGP MGVFEFSNFA QGTIGVCKAI ANLKDAITII 350
GGGDSAAAAI SLGFENDFTH ISTGGGASLE YLEGKELPGI KAINNK 396
Length:396
Mass (Da):42,602
Last modified:July 19, 2004 - v1
Checksum:iC8383CFDBC5BF4EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39838.1.
RefSeqiYP_040255.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39838; CAG39838; SAR0829.
GeneIDi2859899.
KEGGisar:SAR0829.
PATRICi19545195. VBIStaAur71814_0830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39838.1 .
RefSeqi YP_040255.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DG5 X-ray 2.30 A 2-396 [» ]
ProteinModelPortali Q6GIL7.
SMRi Q6GIL7. Positions 2-396.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR0829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG39838 ; CAG39838 ; SAR0829 .
GeneIDi 2859899.
KEGGi sar:SAR0829.
PATRICi 19545195. VBIStaAur71814_0830.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci SAUR282458:GJA5-832-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiPGK_STAAR
AccessioniPrimary (citable) accession number: Q6GIL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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