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Q6GII7 (AROD_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10
Alternative name(s):
Type I DHQase
Gene names
Name:aroD
Ordered Locus Names:SAR0860
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214

Subunit structure

Homodimer By similarity. HAMAP MF_00214

Sequence similarities

Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2382383-dehydroquinate dehydratase HAMAP MF_00214
PRO_0000138811

Sites

Active site1331Proton acceptor By similarity
Active site1601Schiff-base intermediate with substrate By similarity

Secondary structure

1 ....................................... 238
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q6GII7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: A88C60679FCCBCF4

FASTA23827,053
        10         20         30         40         50         60 
MTHVEVVATI TPQLYIEETL IQKINHRIDA IDVLELRIDQ FENVTVDQVA EMITKLKVMQ 

        70         80         90        100        110        120 
DSFKLLVTYR TKLQGGYGQF TNDSYLNLIS DLANINGIDM IDIEWQADID IEKHQRIITH 

       130        140        150        160        170        180 
LQQYNKEVII SHHNFESTPP LDELQFIFFK MQKFNPEYVK LAVMPHNKND VLNLLQAMST 

       190        200        210        220        230 
FSDTMDCKVV GISMSKLGLI SRTAQGVFGG ALTYGCIGEP QAPGQIDVTD LKAQVTLY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571856 Genomic DNA. Translation: CAG39869.1.
RefSeqYP_040285.1. NC_002952.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1SFJX-ray2.40A/B1-238[»]
ProteinModelPortalQ6GII7.
SMRQ6GII7. Positions 3-238.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6GII7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000020227; EBSTAP00000019563; EBSTAG00000020226.
GeneID2860881.
GenomeReviewsGene locus SAR0860 in contig BX571856_GR.
KEGGsar:SAR0860.
PATRIC19545257. VBIStaAur71814_0861.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0710.
GeneTreeEBGT00050000025297.
HOGENOMHBG732926.
OMAIAKIAVM.
ProtClustDBPRK13575.

Enzyme and pathway databases

BioCycSAUR282458:SAR0860-MONOMER.

Family and domain databases

HAMAPMF_00214. AroD.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK03785.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
TIGRFAMsTIGR01093. AroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_STAAR
AccessionPrimary (citable) accession number: Q6GII7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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