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Protein

Probable cysteine desulfurase

Gene

csd

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.By similarity

Catalytic activityi

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei368Cysteine persulfide intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cysteine desulfurase (EC:2.8.1.7)
Gene namesi
Name:csd
Ordered Locus Names:SAR0878
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001503121 – 413Probable cysteine desulfuraseAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229N6-(pyridoxal phosphate)lysineBy similarity1

Structurei

3D structure databases

ProteinModelPortaliQ6GIH2.
SMRiQ6GIH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000017511.
KOiK11717.
OMAiAEKVHGK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010970. Cys_dSase_SufS.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GIH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHSFDVNE VIKDFPILDQ KVNGKRLAYL DSTATSQTPV QVLNVLEDYY
60 70 80 90 100
KRYNSNVHRG VHTLGSLATD GYENARETVR RFINAKYFEE IIFTRGTTAS
110 120 130 140 150
INLVAHSYGD ANVEEGDEIV VTEMEHHANI VPWQQLAKRK NATLKFIPMT
160 170 180 190 200
ADGELNIEDI KQTINDKTKI VAIAHISNVL GTINDVKTIA EIAHQHGAII
210 220 230 240 250
SVDGAQAAPH MKLDMQEMNA DFYSFSGHKM LGPTGIGVLF GKRELLQKME
260 270 280 290 300
PIEFGGDMID FVSKYDATWA DLPTKFEAGT PLIAQAIGLA EAIRYLERIG
310 320 330 340 350
FDAIHKYEQE LTIYAYEQMS AIEGIEIYGP PKDRRAGVIT FNLQDVHPHD
360 370 380 390 400
VATAVDTEGV AVRAGHHCAQ PLMKWLNVSS TARASFYIYN TKEDVDQLIN
410
ALKQTKEFFS YEF
Length:413
Mass (Da):46,276
Last modified:July 19, 2004 - v1
Checksum:iCE182696049311DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39884.1.
RefSeqiWP_000807671.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39884; CAG39884; SAR0878.
GeneIDi28381613.
KEGGisar:SAR0878.
PATRICi19545289. VBIStaAur71814_0877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39884.1.
RefSeqiWP_000807671.1. NC_002952.2.

3D structure databases

ProteinModelPortaliQ6GIH2.
SMRiQ6GIH2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG39884; CAG39884; SAR0878.
GeneIDi28381613.
KEGGisar:SAR0878.
PATRICi19545289. VBIStaAur71814_0877.

Phylogenomic databases

HOGENOMiHOG000017511.
KOiK11717.
OMAiAEKVHGK.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010970. Cys_dSase_SufS.
IPR016454. Cysteine_dSase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF005572. NifS. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCSD_STAAR
AccessioniPrimary (citable) accession number: Q6GIH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.