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Q6GIC7

- ASSY_STAAR

UniProt

Q6GIC7 - ASSY_STAAR

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Protein

Argininosuccinate synthase

Gene
argG, SAR0923
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei173 – 1731Citrulline By similarity
Binding sitei258 – 2581Citrulline By similarity
Binding sitei270 – 2701Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-924-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:SAR0923
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthaseUniRule annotationPRO_0000148638Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi282458.SAR0923.

Structurei

3D structure databases

ProteinModelPortaliQ6GIC7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GIC7-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKIVLAYS GGLDTSVAVQ WLIDKGYDVV ACCLDVGEGK DLDIVYKKAL    50
DMRAVECHII DATKEFSDEY VSYAIKGNLM YENAYPLVSA LSRPLIAKKL 100
VEIAEKTNSV GIAHGCTGKG NDQVRFEVAI KALNPSLKAF APVREWAWSR 150
EEEIDYAIKH NIPVSINHDS PYSIDQNLWG RANECGILED PYAAPPEDAF 200
DLTNALEETP DTADEIILTF DKGIPVQIDG KTYELDDLIL TLNALAGKHG 250
IGRIDHVENR LVGIKSREIY EAPAAEVILK AHKALETITL TKDVAHFKPI 300
IEKQFAEQLY NGLWFSPLTD SLKLFIDSTQ QYVSGDVRIK LFKGNAIVNG 350
RKSPYTLYDE KLATYTKEDA FNQDAAVGFI DIYGLPTQVN AMLHGGYSNE 400
Q 401
Length:401
Mass (Da):44,555
Last modified:July 19, 2004 - v1
Checksum:iDD7482F302567B96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39929.1.
RefSeqiYP_040345.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39929; CAG39929; SAR0923.
GeneIDi2859853.
KEGGisar:SAR0923.
PATRICi19545379. VBIStaAur71814_0922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG39929.1 .
RefSeqi YP_040345.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GIC7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR0923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG39929 ; CAG39929 ; SAR0923 .
GeneIDi 2859853.
KEGGi sar:SAR0923.
PATRICi 19545379. VBIStaAur71814_0922.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SAUR282458:GJA5-924-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiASSY_STAAR
AccessioniPrimary (citable) accession number: Q6GIC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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