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Protein

Serine protease HtrA-like

Gene

SAR0992

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei504Charge relay systemSequence analysis1
Active sitei534Charge relay systemSequence analysis1
Active sitei619Charge relay systemSequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine protease HtrA-like (EC:3.4.21.-)
Gene namesi
Ordered Locus Names:SAR0992
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524681 – 769Serine protease HtrA-likeAdd BLAST769

Structurei

3D structure databases

ProteinModelPortaliQ6GI62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini680 – 733PDZAdd BLAST54

Sequence similaritiesi

Belongs to the peptidase S1C family.Curated
Contains 1 PDZ (DHR) domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000279952.
OMAiRNMAIND.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GI62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIGKKHVIP KSQYRRKRRE FFHNEDREEN LNQHQDKQNI DNTTSKKADK
60 70 80 90 100
QIHKDSIDKH ERFKNSLSSH LEQRNRDVNE NKAEESKSNQ GSKSAYNKDH
110 120 130 140 150
YLTDDVSKKQ NSLDSVDQDT EKSKYYEQNT EATLSTNSTD KVESTDMRKL
160 170 180 190 200
SSDKNKVGHE EQHVLSKPSE HDKETRIDFE SSRTDSDSSM QTEKIKKDSS
210 220 230 240 250
DGNKSSNLKS EVISDKSNSV PILSESDDEV NNQKPLTLPE EQKLKRQQSQ
260 270 280 290 300
NEQTKTYTYG DSEQNDKSNH ENDLSHHTPS ISDDKDYVMR EDHIVDDNPD
310 320 330 340 350
NDINTPSLSK IDDDRKLDEK IHVEDKHKQN ADSSETVGYQ SQSSASHRST
360 370 380 390 400
EKRNMAINDH DKLNGQKPNT KTSANNNQKK ATSKLNKGRA TNNNYSAILK
410 420 430 440 450
KFWMMYWPKL VILMGIIILI VILNAIFNNV NKNDRMNDNN DADAQKYTTT
460 470 480 490 500
MKNANNAVKS VVTVENETSK DSSLPKDKAS QDEVGSGVVY KKSGDTLYIV
510 520 530 540 550
TNAHVVGDKE NQKITFSNNK SVVGKVLGKD KWSDLAVVKA TSSDSSVKEI
560 570 580 590 600
AIGDSNNLVL GEPILVVGNP LGVDFKGTVT EGIISGLNRN VPIDFDKDNK
610 620 630 640 650
YDMLMKAFQI DASVNPGNSG GAVVNREGKL IGVVAAKISM PNVENMSFAI
660 670 680 690 700
PVNEVQKIVK ELETKGKIDY PDVGVKMKNI ASLNSFERQA VKLLGKVKNG
710 720 730 740 750
VVVDQVDNNG LADQSGLKKG DVITELDGKL LEDDLRFRQI IFSHKDDLKS
760
ITAKIYRDGK EKEINIKLK
Length:769
Mass (Da):86,353
Last modified:July 19, 2004 - v1
Checksum:iE7E17A560179FA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39997.1.
RefSeqiWP_000351046.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG39997; CAG39997; SAR0992.
KEGGisar:SAR0992.
PATRICi19545519. VBIStaAur71814_0992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG39997.1.
RefSeqiWP_000351046.1. NC_002952.2.

3D structure databases

ProteinModelPortaliQ6GI62.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG39997; CAG39997; SAR0992.
KEGGisar:SAR0992.
PATRICi19545519. VBIStaAur71814_0992.

Phylogenomic databases

HOGENOMiHOG000279952.
OMAiRNMAIND.

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-960-MONOMER.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHTRAL_STAAR
AccessioniPrimary (citable) accession number: Q6GI62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.