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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR282458:G1G3O-1103-MONOMER
UniPathwayiUPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:SAR1040
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001008721 – 234Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST234

Proteomic databases

PRIDEiQ6GI18

Structurei

3D structure databases

ProteinModelPortaliQ6GI18
SMRiQ6GI18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000082629
KOiK01923
OMAiFNAQKRG

Family and domain databases

CDDicd01415 SAICAR_synt_PurC, 1 hit
HAMAPiMF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR028923 SAICAR_synt/ADE2_N
IPR033934 SAICAR_synt_PurC
IPR001636 SAICAR_synth
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF01259 SAICAR_synt, 1 hit
TIGRFAMsiTIGR00081 purC, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GI18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLYEGKAK RIFSTNQENE LRVEYKDEVT AGNGAKKDTM AGKGRLNNQI
60 70 80 90 100
TSIIFKYLQE NGIESHFIKQ LSETEQLVKP VKIIPLEVVV RNIASGSITK
110 120 130 140 150
RLGFENGEVF REPLVEFFYK NDALNDPLIT DDHIKLLNIA TDKDIETLKT
160 170 180 190 200
KALEINQVLK QLMHAMSLKL VDFKIEFGKT ETGQILLADE ISPDTCRIWD
210 220 230
KATNANFDKD VYRNNTGSLI ETYQIFLNKL EDLK
Length:234
Mass (Da):26,732
Last modified:July 19, 2004 - v1
Checksum:i9B808F9BD3E6B520
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG40043.1
RefSeqiWP_000174051.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG40043; CAG40043; SAR1040
KEGGisar:SAR1040

Similar proteinsi

Entry informationi

Entry nameiPUR7_STAAR
AccessioniPrimary (citable) accession number: Q6GI18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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