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Q6GI10 (PUR2_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:SAR1048
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151481

Regions

Domain108 – 311204ATP-grasp
Nucleotide binding134 – 19158ATP By similarity

Sites

Metal binding2811Magnesium or manganese By similarity
Metal binding2831Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GI10 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: E09101074D200A1A

FASTA41545,849
        10         20         30         40         50         60 
MNVLVIGAGG REHALAYKLN QSNLVKQVFV IPGNEAMTPI AEVHTEISES DHQGILDFAK 

        70         80         90        100        110        120 
QQNVDWVVIG PEQPLIDGLA DILRANGFKV FGPNKQAAQI EGSKLFAKKI MEKYNIPTAD 

       130        140        150        160        170        180 
YKEVERKKDA LTYIENCEFP VVVKKDGLAA GKGVIIADTI EAARSAIEIM YGDEEEGTVV 

       190        200        210        220        230        240 
FETFLEGEEF SLMTFVNGEL AVPFDCIAQD HKRAFDHDEG PNTGGMGAYC PVPHISDDVL 

       250        260        270        280        290        300 
KLTNETIAQP IAKAMLNEGY QFFGVLYIGA ILTKDGPKVI EFNARFGDPE AQVLLSRMES 

       310        320        330        340        350        360 
DLMQHIIDLD EGKRTEFKWK NEAIVGVMLA SKGYPDAYEK GHKVSGFDLN ENYFVSGLKK 

       370        380        390        400        410 
QGDTFVTSGG RVILAIGKGD NVHDAQRDAY EKVSQIQSDH LFYRHDIANK ALQLK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571856 Genomic DNA. Translation: CAG40051.1.
RefSeqYP_040462.1. NC_002952.2.

3D structure databases

ProteinModelPortalQ6GI10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING282458.SAR1048.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG40051; CAG40051; SAR1048.
GeneID2859544.
KEGGsar:SAR1048.
PATRIC19545633. VBIStaAur71814_1047.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMAYKGFLYA.
OrthoDBEOG69SKD1.

Enzyme and pathway databases

BioCycSAUR282458:GJA5-1048-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_STAAR
AccessionPrimary (citable) accession number: Q6GI10
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways