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Q6GHZ2

- ODPA_STAAR

UniProt

Q6GHZ2 - ODPA_STAAR

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciSAUR282458:GJA5-1067-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Ordered Locus Names:SAR1067
    OrganismiStaphylococcus aureus (strain MRSA252)
    Taxonomic identifieri282458 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000596: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162208Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi282458.SAR1067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GHZ2.
    SMRiQ6GHZ2. Positions 8-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    HOGENOMiHOG000281335.
    KOiK00161.
    OMAiQYKEHYP.
    OrthoDBiEOG6VMTKR.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GHZ2-1 [UniParc]FASTAAdd to Basket

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    MAPKLQAQFD AVKVLNDTQS KFEMVQILDE NGNVVNEDLV PDLTDEQLVE    50
    LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALEKEDYI 100
    LPGYRDVPQI IWHGLPLTEA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY 150
    IQTAGVAFAL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA AAYKAPAIFV 200
    IQNNNYAIST PRSKQTAAET LAQKAIAVGI PGIQVDGMDA LAVYQATKEA 250
    RDRAVAGEGP TLIETMTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR 300
    FRKFLENKGL WNEDKENEVI ERAKADIKAA IKEADNTEKQ TVTSLMEIMY 350
    EDMPQNLAEQ YEIYKEKESK 370
    Length:370
    Mass (Da):41,413
    Last modified:July 19, 2004 - v1
    Checksum:i5172134E6FE80EE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40069.1.
    RefSeqiYP_040480.1. NC_002952.2.

    Genome annotation databases

    EnsemblBacteriaiCAG40069; CAG40069; SAR1067.
    GeneIDi2859889.
    KEGGisar:SAR1067.
    PATRICi19545675. VBIStaAur71814_1068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40069.1 .
    RefSeqi YP_040480.1. NC_002952.2.

    3D structure databases

    ProteinModelPortali Q6GHZ2.
    SMRi Q6GHZ2. Positions 8-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282458.SAR1067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG40069 ; CAG40069 ; SAR1067 .
    GeneIDi 2859889.
    KEGGi sar:SAR1067.
    PATRICi 19545675. VBIStaAur71814_1068.

    Phylogenomic databases

    eggNOGi COG1071.
    HOGENOMi HOG000281335.
    KOi K00161.
    OMAi QYKEHYP.
    OrthoDBi EOG6VMTKR.

    Enzyme and pathway databases

    BioCyci SAUR282458:GJA5-1067-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MRSA252.

    Entry informationi

    Entry nameiODPA_STAAR
    AccessioniPrimary (citable) accession number: Q6GHZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3