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Q6GHZ2

- ODPA_STAAR

UniProt

Q6GHZ2 - ODPA_STAAR

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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene
pdhA, SAR1067
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-1067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:SAR1067
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162208Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi282458.SAR1067.

Structurei

3D structure databases

ProteinModelPortaliQ6GHZ2.
SMRiQ6GHZ2. Positions 8-370.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281335.
KOiK00161.
OMAiQYKEHYP.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GHZ2-1 [UniParc]FASTAAdd to Basket

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MAPKLQAQFD AVKVLNDTQS KFEMVQILDE NGNVVNEDLV PDLTDEQLVE    50
LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALEKEDYI 100
LPGYRDVPQI IWHGLPLTEA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY 150
IQTAGVAFAL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA AAYKAPAIFV 200
IQNNNYAIST PRSKQTAAET LAQKAIAVGI PGIQVDGMDA LAVYQATKEA 250
RDRAVAGEGP TLIETMTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR 300
FRKFLENKGL WNEDKENEVI ERAKADIKAA IKEADNTEKQ TVTSLMEIMY 350
EDMPQNLAEQ YEIYKEKESK 370
Length:370
Mass (Da):41,413
Last modified:July 19, 2004 - v1
Checksum:i5172134E6FE80EE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40069.1.
RefSeqiYP_040480.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40069; CAG40069; SAR1067.
GeneIDi2859889.
KEGGisar:SAR1067.
PATRICi19545675. VBIStaAur71814_1068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40069.1 .
RefSeqi YP_040480.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GHZ2.
SMRi Q6GHZ2. Positions 8-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40069 ; CAG40069 ; SAR1067 .
GeneIDi 2859889.
KEGGi sar:SAR1067.
PATRICi 19545675. VBIStaAur71814_1068.

Phylogenomic databases

eggNOGi COG1071.
HOGENOMi HOG000281335.
KOi K00161.
OMAi QYKEHYP.
OrthoDBi EOG6VMTKR.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-1067-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 1 hit.
InterProi IPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view ]
Pfami PF00676. E1_dh. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiODPA_STAAR
AccessioniPrimary (citable) accession number: Q6GHZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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