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Protein

Glutamate racemase

Gene

murI

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation1 Publication

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donor/acceptorUniRule annotationBy similarity1
Active sitei184Proton donor/acceptorUniRule annotationBy similarity1

GO - Molecular functioni

  • glutamate racemase activity Source: UniProtKB-EC
  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation1 Publication)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:SAR1123
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000955101 – 266Glutamate racemaseAdd BLAST266

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-15642790,EBI-15642790

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-60302N

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 12Combined sources8
Helixi15 – 24Combined sources10
Beta strandi30 – 34Combined sources5
Turni36 – 38Combined sources3
Helixi46 – 60Combined sources15
Beta strandi66 – 70Combined sources5
Helixi73 – 86Combined sources14
Beta strandi88 – 94Combined sources7
Helixi95 – 105Combined sources11
Beta strandi107 – 115Combined sources9
Helixi117 – 122Combined sources6
Helixi124 – 132Combined sources9
Beta strandi137 – 142Combined sources6
Helixi146 – 151Combined sources6
Helixi158 – 169Combined sources12
Helixi170 – 172Combined sources3
Beta strandi178 – 186Combined sources9
Helixi187 – 190Combined sources4
Helixi191 – 197Combined sources7
Turni198 – 200Combined sources3
Beta strandi202 – 206Combined sources5
Helixi207 – 221Combined sources15
Beta strandi235 – 240Combined sources6
Helixi243 – 253Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JFQX-ray2.15A/B1-266[»]
ProteinModelPortaliQ6GHT5
SMRiQ6GHT5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6GHT5

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 10Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni41 – 42Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni73 – 74Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni185 – 186Substrate bindingUniRule annotationCombined sources1 Publication2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262396
KOiK01776
OMAiVYGCTHY

Family and domain databases

HAMAPiMF_00258 Glu_racemase, 1 hit
InterProiView protein in InterPro
IPR015942 Asp/Glu/hydantoin_racemase
IPR001920 Asp/Glu_race
IPR018187 Asp/Glu_racemase_AS_1
IPR033134 Asp/Glu_racemase_AS_2
IPR004391 Glu_race
PANTHERiPTHR21198:SF2 PTHR21198:SF2, 1 hit
PfamiView protein in Pfam
PF01177 Asp_Glu_race, 1 hit
SUPFAMiSSF53681 SSF53681, 2 hits
TIGRFAMsiTIGR00067 glut_race, 1 hit
PROSITEiView protein in PROSITE
PS00923 ASP_GLU_RACEMASE_1, 1 hit
PS00924 ASP_GLU_RACEMASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GHT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPIGVIDS GVGGLTVAKE IMRQLPNETI YYLGDIGRCP YGPRPGEQVK
60 70 80 90 100
QYTVEIARKL MEFDIKMLVI ACNTATAVAL EYLQKTLSIP VIGVIEPGAR
110 120 130 140 150
TAIMTTRNQN VLVLGTEGTI KSEAYRTHIK RINPHVEVHG VACPGFVPLV
160 170 180 190 200
EQMRYSDPTI TSIVIHQTLK RWRNSESDTV ILGCTHYPLL YKPIYDYFGG
210 220 230 240 250
KKTVISSGLE TAREVSALLT FSNEHASYTE HPDHRFFATG DTTHITNIIK
260
EWLNLSVNVE RISVND
Length:266
Mass (Da):29,702
Last modified:July 19, 2004 - v1
Checksum:i97FC71DB4A2C7B0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG40126.1
RefSeqiWP_001039660.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG40126; CAG40126; SAR1123
KEGGisar:SAR1123

Similar proteinsi

Entry informationi

Entry nameiMURI_STAAR
AccessioniPrimary (citable) accession number: Q6GHT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health