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Protein

Glutamate racemase

Gene

murI

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides the (R)-glutamate required for cell wall biosynthesis.UniRule annotation

Catalytic activityi

L-glutamate = D-glutamate.UniRule annotation1 Publication

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton donor/acceptorUniRule annotationBy similarity1
Active sitei184Proton donor/acceptorUniRule annotationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate racemaseUniRule annotation (EC:5.1.1.3UniRule annotation1 Publication)
Gene namesi
Name:murIUniRule annotation
Ordered Locus Names:SAR1123
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000955101 – 266Glutamate racemaseAdd BLAST266

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

DIPiDIP-60302N.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 12Combined sources8
Helixi15 – 24Combined sources10
Beta strandi30 – 34Combined sources5
Turni36 – 38Combined sources3
Helixi46 – 60Combined sources15
Beta strandi66 – 70Combined sources5
Helixi73 – 86Combined sources14
Beta strandi88 – 94Combined sources7
Helixi95 – 105Combined sources11
Beta strandi107 – 115Combined sources9
Helixi117 – 122Combined sources6
Helixi124 – 132Combined sources9
Beta strandi137 – 142Combined sources6
Helixi146 – 151Combined sources6
Helixi158 – 169Combined sources12
Helixi170 – 172Combined sources3
Beta strandi178 – 186Combined sources9
Helixi187 – 190Combined sources4
Helixi191 – 197Combined sources7
Turni198 – 200Combined sources3
Beta strandi202 – 206Combined sources5
Helixi207 – 221Combined sources15
Beta strandi235 – 240Combined sources6
Helixi243 – 253Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JFQX-ray2.15A/B1-266[»]
ProteinModelPortaliQ6GHT5.
SMRiQ6GHT5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6GHT5.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 10Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni41 – 42Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni73 – 74Substrate bindingUniRule annotationCombined sources1 Publication2
Regioni185 – 186Substrate bindingUniRule annotationCombined sources1 Publication2

Sequence similaritiesi

Belongs to the aspartate/glutamate racemases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GHT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPIGVIDS GVGGLTVAKE IMRQLPNETI YYLGDIGRCP YGPRPGEQVK
60 70 80 90 100
QYTVEIARKL MEFDIKMLVI ACNTATAVAL EYLQKTLSIP VIGVIEPGAR
110 120 130 140 150
TAIMTTRNQN VLVLGTEGTI KSEAYRTHIK RINPHVEVHG VACPGFVPLV
160 170 180 190 200
EQMRYSDPTI TSIVIHQTLK RWRNSESDTV ILGCTHYPLL YKPIYDYFGG
210 220 230 240 250
KKTVISSGLE TAREVSALLT FSNEHASYTE HPDHRFFATG DTTHITNIIK
260
EWLNLSVNVE RISVND
Length:266
Mass (Da):29,702
Last modified:July 19, 2004 - v1
Checksum:i97FC71DB4A2C7B0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40126.1.
RefSeqiWP_001039660.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40126; CAG40126; SAR1123.
KEGGisar:SAR1123.
PATRICi19545793. VBIStaAur71814_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40126.1.
RefSeqiWP_001039660.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JFQX-ray2.15A/B1-266[»]
ProteinModelPortaliQ6GHT5.
SMRiQ6GHT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60302N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG40126; CAG40126; SAR1123.
KEGGisar:SAR1123.
PATRICi19545793. VBIStaAur71814_1127.

Phylogenomic databases

HOGENOMiHOG000262396.
KOiK01776.
OMAiVPYGSKS.

Enzyme and pathway databases

UniPathwayiUPA00219.

Miscellaneous databases

EvolutionaryTraceiQ6GHT5.

Family and domain databases

Gene3Di3.40.50.1860. 1 hit.
HAMAPiMF_00258. Glu_racemase. 1 hit.
InterProiIPR015942. Asp/Glu/hydantoin_racemase.
IPR001920. Asp/Glu_race.
IPR018187. Asp/Glu_racemase_AS_1.
IPR033134. Asp/Glu_racemase_AS_2.
IPR004391. Glu_race.
[Graphical view]
PfamiPF01177. Asp_Glu_race. 1 hit.
[Graphical view]
SUPFAMiSSF53681. SSF53681. 2 hits.
TIGRFAMsiTIGR00067. glut_race. 1 hit.
PROSITEiPS00923. ASP_GLU_RACEMASE_1. 1 hit.
PS00924. ASP_GLU_RACEMASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURI_STAAR
AccessioniPrimary (citable) accession number: Q6GHT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.