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Q6GHN7 (PYRR_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein PyrR

Including the following 2 domains:

  1. Pyrimidine operon regulatory protein
  2. Uracil phosphoribosyltransferase
    Short name=UPRTase
    EC=2.4.2.9
Gene names
Name:pyrR
Ordered Locus Names:SAR1174
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length175 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes By similarity. HAMAP-Rule MF_01219

Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity. HAMAP-Rule MF_01219

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01219

Subunit structure

Homodimer and homohexamer; in equilibrium By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 175175Bifunctional protein PyrR HAMAP-Rule MF_01219
PRO_0000183056

Regions

Region40 – 412Substrate-binding By similarity
Region102 – 1109Substrate binding By similarity
Motif98 – 11013PRPP-binding By similarity

Sites

Binding site1351Substrate By similarity
Binding site1591Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GHN7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 88409753D5CC5FB0

FASTA17519,855
        10         20         30         40         50         60 
MSERIIMDDA AIQRTVTRIA HEILEYNKGT DNLILLGIKT RGEYLANRIQ DKIHQIEQQR 

        70         80         90        100        110        120 
IPTGTIDITY FRDDIEHMSS LTTKDAIDID TDITDKVVII IDDVLYTGRT VRASLDAILL 

       130        140        150        160        170 
NARPIKIGLA ALVDRGHREL PIRADFVGKN IPTSKEETVS VYLEEMDQRN AVIIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571856 Genomic DNA. Translation: CAG40176.1.
RefSeqYP_040585.1. NC_002952.2.

3D structure databases

ProteinModelPortalQ6GHN7.
SMRQ6GHN7. Positions 5-174.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING282458.SAR1174.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG40176; CAG40176; SAR1174.
GeneID2859291.
KEGGsar:SAR1174.
PATRIC19545895. VBIStaAur71814_1177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2065.
HOGENOMHOG000245770.
KOK02825.
OMALMDMGRP.
OrthoDBEOG61VZD8.

Enzyme and pathway databases

BioCycSAUR282458:GJA5-1177-MONOMER.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01219. PyrR.
InterProIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRR_STAAR
AccessionPrimary (citable) accession number: Q6GHN7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families