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Q6GHN7

- PYRR_STAAR

UniProt

Q6GHN7 - PYRR_STAAR

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Protein
Bifunctional protein PyrR
Gene
pyrR, SAR1174
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes By similarity.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351Substrate By similarity
Binding sitei159 – 1591Substrate By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-HAMAP
  2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-1177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrR
Including the following 2 domains:
Pyrimidine operon regulatory protein
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Short name:
UPRTase
Gene namesi
Name:pyrR
Ordered Locus Names:SAR1174
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Bifunctional protein PyrRUniRule annotation
PRO_0000183056Add
BLAST

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium By similarity.

Protein-protein interaction databases

STRINGi282458.SAR1174.

Structurei

3D structure databases

ProteinModelPortaliQ6GHN7.
SMRiQ6GHN7. Positions 5-174.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 412Substrate-binding By similarity
Regioni102 – 1109Substrate binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi98 – 11013PRPP-binding By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2065.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GHN7-1 [UniParc]FASTAAdd to Basket

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MSERIIMDDA AIQRTVTRIA HEILEYNKGT DNLILLGIKT RGEYLANRIQ    50
DKIHQIEQQR IPTGTIDITY FRDDIEHMSS LTTKDAIDID TDITDKVVII 100
IDDVLYTGRT VRASLDAILL NARPIKIGLA ALVDRGHREL PIRADFVGKN 150
IPTSKEETVS VYLEEMDQRN AVIIK 175
Length:175
Mass (Da):19,855
Last modified:July 19, 2004 - v1
Checksum:i88409753D5CC5FB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40176.1.
RefSeqiYP_040585.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40176; CAG40176; SAR1174.
GeneIDi2859291.
KEGGisar:SAR1174.
PATRICi19545895. VBIStaAur71814_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40176.1 .
RefSeqi YP_040585.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GHN7.
SMRi Q6GHN7. Positions 5-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40176 ; CAG40176 ; SAR1174 .
GeneIDi 2859291.
KEGGi sar:SAR1174.
PATRICi 19545895. VBIStaAur71814_1177.

Phylogenomic databases

eggNOGi COG2065.
HOGENOMi HOG000245770.
KOi K02825.
OMAi LMDMGRP.
OrthoDBi EOG61VZD8.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-1177-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01219. PyrR.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiPYRR_STAAR
AccessioniPrimary (citable) accession number: Q6GHN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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