Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6GHN7

- PYRR_STAAR

UniProt

Q6GHN7 - PYRR_STAAR

Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
    Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei135 – 1351SubstrateBy similarity
    Binding sitei159 – 1591SubstrateBy similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-HAMAP
    2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. nucleoside metabolic process Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription termination

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    BioCyciSAUR282458:GJA5-1177-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein PyrRUniRule annotation
    Including the following 2 domains:
    Pyrimidine operon regulatory proteinUniRule annotation
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Short name:
    UPRTaseUniRule annotation
    Gene namesi
    Name:pyrRUniRule annotation
    Ordered Locus Names:SAR1174
    OrganismiStaphylococcus aureus (strain MRSA252)
    Taxonomic identifieri282458 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000596: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 175175Bifunctional protein PyrRPRO_0000183056Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer and homohexamer; in equilibrium.UniRule annotation

    Protein-protein interaction databases

    STRINGi282458.SAR1174.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GHN7.
    SMRiQ6GHN7. Positions 5-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni40 – 412Substrate-bindingBy similarity
    Regioni102 – 1109Substrate bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi98 – 11013PRPP-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2065.
    HOGENOMiHOG000245770.
    KOiK02825.
    OMAiLMDMGRP.
    OrthoDBiEOG61VZD8.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01219. PyrR.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GHN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSERIIMDDA AIQRTVTRIA HEILEYNKGT DNLILLGIKT RGEYLANRIQ    50
    DKIHQIEQQR IPTGTIDITY FRDDIEHMSS LTTKDAIDID TDITDKVVII 100
    IDDVLYTGRT VRASLDAILL NARPIKIGLA ALVDRGHREL PIRADFVGKN 150
    IPTSKEETVS VYLEEMDQRN AVIIK 175
    Length:175
    Mass (Da):19,855
    Last modified:July 19, 2004 - v1
    Checksum:i88409753D5CC5FB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40176.1.
    RefSeqiYP_040585.1. NC_002952.2.

    Genome annotation databases

    EnsemblBacteriaiCAG40176; CAG40176; SAR1174.
    GeneIDi2859291.
    KEGGisar:SAR1174.
    PATRICi19545895. VBIStaAur71814_1177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40176.1 .
    RefSeqi YP_040585.1. NC_002952.2.

    3D structure databases

    ProteinModelPortali Q6GHN7.
    SMRi Q6GHN7. Positions 5-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282458.SAR1174.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG40176 ; CAG40176 ; SAR1174 .
    GeneIDi 2859291.
    KEGGi sar:SAR1174.
    PATRICi 19545895. VBIStaAur71814_1177.

    Phylogenomic databases

    eggNOGi COG2065.
    HOGENOMi HOG000245770.
    KOi K02825.
    OMAi LMDMGRP.
    OrthoDBi EOG61VZD8.

    Enzyme and pathway databases

    BioCyci SAUR282458:GJA5-1177-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01219. PyrR.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MRSA252.

    Entry informationi

    Entry nameiPYRR_STAAR
    AccessioniPrimary (citable) accession number: Q6GHN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3