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Q6GHN7

- PYRR_STAAR

UniProt

Q6GHN7 - PYRR_STAAR

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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei135 – 1351SubstrateBy similarity
Binding sitei159 – 1591SubstrateBy similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-HAMAP
  2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription termination

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-1177-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Pyrimidine operon regulatory proteinUniRule annotation
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:SAR1174
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Bifunctional protein PyrRPRO_0000183056Add
BLAST

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi282458.SAR1174.

Structurei

3D structure databases

ProteinModelPortaliQ6GHN7.
SMRiQ6GHN7. Positions 5-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 412Substrate-bindingBy similarity
Regioni102 – 1109Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi98 – 11013PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2065.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GHN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSERIIMDDA AIQRTVTRIA HEILEYNKGT DNLILLGIKT RGEYLANRIQ
60 70 80 90 100
DKIHQIEQQR IPTGTIDITY FRDDIEHMSS LTTKDAIDID TDITDKVVII
110 120 130 140 150
IDDVLYTGRT VRASLDAILL NARPIKIGLA ALVDRGHREL PIRADFVGKN
160 170
IPTSKEETVS VYLEEMDQRN AVIIK
Length:175
Mass (Da):19,855
Last modified:July 19, 2004 - v1
Checksum:i88409753D5CC5FB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40176.1.
RefSeqiYP_040585.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40176; CAG40176; SAR1174.
GeneIDi2859291.
KEGGisar:SAR1174.
PATRICi19545895. VBIStaAur71814_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40176.1 .
RefSeqi YP_040585.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GHN7.
SMRi Q6GHN7. Positions 5-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1174.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40176 ; CAG40176 ; SAR1174 .
GeneIDi 2859291.
KEGGi sar:SAR1174.
PATRICi 19545895. VBIStaAur71814_1177.

Phylogenomic databases

eggNOGi COG2065.
HOGENOMi HOG000245770.
KOi K02825.
OMAi LMDMGRP.
OrthoDBi EOG61VZD8.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-1177-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01219. PyrR.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiPYRR_STAAR
AccessioniPrimary (citable) accession number: Q6GHN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3