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Q6GHK5

- FABD_STAAR

UniProt

Q6GHK5 - FABD_STAAR

Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891By similarity
    Active sitei199 – 1991By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSAUR282458:GJA5-1209-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:fabD
    Ordered Locus Names:SAR1206
    OrganismiStaphylococcus aureus (strain MRSA252)
    Taxonomic identifieri282458 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000596: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Malonyl CoA-acyl carrier protein transacylasePRO_0000194222Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi282458.SAR1206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GHK5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    HOGENOMiHOG000036504.
    KOiK00645.
    OMAiIWRVWQE.
    OrthoDBiEOG6W19KW.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000446. Mct. 1 hit.
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsiTIGR00128. fabD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GHK5-1 [UniParc]FASTAAdd to Basket

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    MSKTAIIFPG QGAQKVGMAQ DLYNNNDQAT EILTSAANTL DFDILETMFT    50
    DEEGKLGETE NTQPALLTHS SALLAALKNL NPDFTMGHSL GEYSSLVAAD 100
    VLSFEDAVKI VRKRGQLMAQ AFPSGVGSMA AVLGLDFDKV DEICKSLSSD 150
    DKIIEPANIN CPGQIVVSGH KALIDELVEK GKSLGAKRVM PLAVSGPFHS 200
    SLMKVIEEDF SSYINQFEWR DAKFPVVQNV NAQGETDKEV IKSNMVKQLY 250
    SPVQFINSTE WLIDQGVDHF IEIGPGKVLS GLIKKINRDV KLTSIQTLED 300
    VKGWNEND 308
    Length:308
    Mass (Da):33,637
    Last modified:July 19, 2004 - v1
    Checksum:i00477FE1D518DC88
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40208.1.
    RefSeqiYP_040617.1. NC_002952.2.

    Genome annotation databases

    EnsemblBacteriaiCAG40208; CAG40208; SAR1206.
    GeneIDi2859617.
    KEGGisar:SAR1206.
    PATRICi19545959. VBIStaAur71814_1209.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40208.1 .
    RefSeqi YP_040617.1. NC_002952.2.

    3D structure databases

    ProteinModelPortali Q6GHK5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282458.SAR1206.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG40208 ; CAG40208 ; SAR1206 .
    GeneIDi 2859617.
    KEGGi sar:SAR1206.
    PATRICi 19545959. VBIStaAur71814_1209.

    Phylogenomic databases

    eggNOGi COG0331.
    HOGENOMi HOG000036504.
    KOi K00645.
    OMAi IWRVWQE.
    OrthoDBi EOG6W19KW.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci SAUR282458:GJA5-1209-MONOMER.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000446. Mct. 1 hit.
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsi TIGR00128. fabD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MRSA252.

    Entry informationi

    Entry nameiFABD_STAAR
    AccessioniPrimary (citable) accession number: Q6GHK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3