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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi: L-tyrosine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route).
Proteins known to be involved in this subpathway in this organism are:
  1. Prephenate dehydrogenase (tyrA)
This subpathway is part of the pathway L-tyrosine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route), the pathway L-tyrosine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi3 – 33NADSequence analysisAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00122; UER00961

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SAR1378
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826561 – 363Prephenate dehydrogenaseAdd BLAST363

Proteomic databases

PRIDEiQ6GH39

Structurei

3D structure databases

ProteinModelPortaliQ6GH39
SMRiQ6GH39
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 291Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd BLAST290
Domaini296 – 363ACTPROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000043494
KOiK04517
OMAiMWRDICL

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR002912 ACT_dom
IPR036291 NAD(P)-bd_dom_sf
IPR003099 Prephen_DH
PfamiView protein in Pfam
PF02153 PDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS51671 ACT, 1 hit
PS51176 PDH_ADH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GH39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE
60 70 80 90 100
KCLNYSEAIK KADVIIYATP VAITNKYLSE LIHMPTKPGV IVSDTGSTKA
110 120 130 140 150
MIQQHECSLL KHNIHLVSGH PMAGSHKSGV LNAKKHLFEN AYYILVYNEP
160 170 180 190 200
RNEQAANTLK ELLSPTLAKF IVTTAEEHDY VTSVVSHLPH IVASSLVHVS
210 220 230 240 250
QKNSQEHHLV NKLAAGGFRD ITRIASSNAQ MWKDITLSNK TYILEMIRQL
260 270 280 290 300
KSQFQDLERL IESNDSEKLL SFFAEAKSYR DALPAKQLGG LNTAYDLYVD
310 320 330 340 350
IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER
360
GMQALSDFDC YIQ
Length:363
Mass (Da):40,421
Last modified:July 19, 2004 - v1
Checksum:i6BE50F4A89852C49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG40376.1
RefSeqiWP_000214282.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG40376; CAG40376; SAR1378
KEGGisar:SAR1378

Similar proteinsi

Entry informationi

Entry nameiTYRA_STAAR
AccessioniPrimary (citable) accession number: Q6GH39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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