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Q6GGZ6 (ODO2_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
EC=2.3.1.61
Alternative name(s):
2-oxoglutarate dehydrogenase complex component E2
Short name=OGDC-E2
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex
Gene names
Name:odhB
Synonyms:sucB
Ordered Locus Names:SAR1424
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activity

Succinyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-succinyldihydrolipoyl)lysine.

Cofactor

Binds 1 lipoyl cofactor covalently By similarity.

Pathway

Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.

Subunit structure

Forms a 24-polypeptide structural core with octahedral symmetry By similarity.

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family.

Contains 1 lipoyl-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
PRO_0000288100

Regions

Domain2 – 7574Lipoyl-binding

Sites

Active site3941 By similarity
Active site3981 By similarity

Amino acid modifications

Modified residue421N6-lipoyllysine Potential

Sequences

Sequence LengthMass (Da)Tools
Q6GGZ6 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 50F814EE00B66830

FASTA42346,773
        10         20         30         40         50         60 
MPEVKVPELA ESITEGTIAE WLKNLGDSVE KGEAILELET DKVNVEVVSE EAGVLSEQLA 

        70         80         90        100        110        120 
SEGDTVEVGQ AIAVIGEGSG NASKENSNDN TPQQNDETTN NKKEETTNKS ADKAEVNQTN 

       130        140        150        160        170        180 
DDNQQRVNAT PSARRYAREN GVNLAEVSPK TNDVVRKEDI DKKQQAPAST QTTQQAPAKE 

       190        200        210        220        230        240 
EKKYNQYPTK PVIREKMSRR KKTAAKKLLE VSNNTAMLTT FNEVDMTNVM ELRKRKKEQF 

       250        260        270        280        290        300 
MKDHDGTKLG FMSFFTKASV AALKKYPEVN AEIDGDDMIT KQYYDIGVAV STDDGLLVPF 

       310        320        330        340        350        360 
VRDCDKKNFA EIEAEIANLA VKAREKKLGL DDMVNGSFTI TNGGIFGSMM STPIINGNQA 

       370        380        390        400        410        420 
AILGMHSIIT RPIAIDQDTI ENRPMMYIAL SYDHRIIDGK EAVGFLKTIK ELIENPEDLL 


LES

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX571856 Genomic DNA. Translation: CAG40421.1.
RefSeqYP_040826.1. NC_002952.2.

3D structure databases

HSSPHSSP built from PDB template 1GHJ based on UniProtKB P20708.
ProteinModelPortalQ6GGZ6.
SMRQ6GGZ6. Positions 194-420.
ModBaseSearch...

Protein-protein interaction databases

STRING282458.SAR1424.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG40421; CAG40421; SAR1424.
GeneID2859175.
KEGGsar:SAR1424.
PATRIC19546392. VBIStaAur71814_1425.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0508.
HOGENOMHOG000281563.
KOK00658.
OMAGQDIVYK.
ProtClustDBPRK05704.

Enzyme and pathway databases

BioCycSAUR282458:GJA5-1425-MONOMER.
UniPathwayUPA00868; UER00840.

Family and domain databases

Gene3D3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
IPR006255. SucB.
[Graphical view]
PfamPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMSSF51230. Hybrid_motif. 1 hit.
TIGRFAMsTIGR01347. sucB. 1 hit.
PROSITEPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameODO2_STAAR
AccessionPrimary (citable) accession number: Q6GGZ6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2004
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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