Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal transduction histidine-protein kinase ArlS

Gene

arlS

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system, Virulence
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transduction histidine-protein kinase ArlS (EC:2.7.13.3)
Gene namesi
Name:arlS
Ordered Locus Names:SAR1426
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000746921 – 451Signal transduction histidine-protein kinase ArlSAdd BLAST451

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6GGZ4.
SMRiQ6GGZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini178 – 231HAMPPROSITE-ProRule annotationAdd BLAST54
Domaini239 – 451Histidine kinasePROSITE-ProRule annotationAdd BLAST213

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000223177.
KOiK18940.
OMAiMTIMIND.

Family and domain databases

CDDicd06225. HAMP. 1 hit.
cd00082. HisKA. 1 hit.
Gene3Di3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR003660. HAMP_dom.
IPR003594. HATPase_C.
IPR005467. His_kinase_dom.
IPR003661. HisK_dim/P.
IPR004358. Sig_transdc_His_kin-like_C.
PfamiView protein in Pfam
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PRINTSiPR00344. BCTRLSENSOR.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GGZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRKLRNNW IIVTTMITFV TIFLFCLIII FFLKDTLHNS ELDDAERSSS
60 70 80 90 100
DINNLFHSKP VKDISALDLN ASLGNFQEII IYDEHNNKLF ETSNDNTVRV
110 120 130 140 150
EPGYEHRYFD RVIKKRYKGI DYLIIKEPIT TQDFKGYSLL IHSLENYDNI
160 170 180 190 200
VKSLYIIALA FGVIATIITA TISYVFSTQI TKPLVSLSNK MIEIRRDGFQ
210 220 230 240 250
NKLQLNTNYE EIDNLANTFN EMMSQIEESF NQQRQFVEDA SHELRTPLQI
260 270 280 290 300
IQGHLNLIQR WGKKDPAVLE ESLNISIEEM NRIIKLVEEL LELTKGDVND
310 320 330 340 350
ISSEAQTVHI NDEIRSRIHS LKQLHPDYQF DTDLTSKNLE IKMKPHQFEQ
360 370 380 390 400
LFLIFIDNAI KYDVKNKKIK VKTRLKNKQK IIEITDHGIG IPEEDQDFIF
410 420 430 440 450
DRFYRVDKSR SRSQGGNGLG LSIAQKIIQL NGGSIKIKSE INKGTTFKII

F
Length:451
Mass (Da):52,386
Last modified:July 19, 2004 - v1
Checksum:iF3D99C9F42B371E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40423.1.
RefSeqiWP_000166793.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40423; CAG40423; SAR1426.
KEGGisar:SAR1426.

Similar proteinsi

Entry informationi

Entry nameiARLS_STAAR
AccessioniPrimary (citable) accession number: Q6GGZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 19, 2004
Last modified: September 27, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program