Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6GGY3 (MSRA2_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA 2

Short name=Protein-methionine-S-oxide reductase 2
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2
Short name=Peptide Met(O) reductase 2
Gene names
Name:msrA2
Ordered Locus Names:SAR1437
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 177177Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401
PRO_0000138586

Sites

Active site121 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GGY3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 6BF0A73224BC98D4

FASTA17720,559
        10         20         30         40         50         60 
MTKEYATLAG GCFWCMVKPF TSYPGIKSVV SGYSGGHADN PTYEQVCTNQ TGHVEAVQIT 

        70         80         90        100        110        120 
FDPEVTSFEN ILDIYFKTFD PTDDQGQFFD RGESYQPVIF YHDKHQKKAA EFKKQQLNEQ 

       130        140        150        160        170 
GIFKKPVITP IKPYKNFYPA EDYHQDYYKK NPVHYYQYQR GSGRKAFIES HWGNQNA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571856 Genomic DNA. Translation: CAG40434.1.
RefSeqYP_040839.1. NC_002952.2.

3D structure databases

ProteinModelPortalQ6GGY3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6GGY3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000021306; EBSTAP00000020642; EBSTAG00000021305.
GeneID2861314.
GenomeReviewsGene locus SAR1437 in contig BX571856_GR.
KEGGsar:SAR1437.
PATRIC19546418. VBIStaAur71814_1438.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0225.
GeneTreeEBGT00050000024265.
HOGENOMHBG748152.
OMALVELYWT.
PhylomeDBQ6GGY3.
ProtClustDBPRK13014.

Enzyme and pathway databases

BioCycSAUR282458:SAR1437-MONOMER.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
KOK07304.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA2_STAAR
AccessionPrimary (citable) accession number: Q6GGY3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families