Q6GGY3 (MSRA2_STAAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 2
Short name=Protein-methionine-S-oxide reductase 2
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 2
Short name=Peptide Met(O) reductase 2

Gene names

Name:	msrA2
Ordered Locus Names:	SAR1437

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Peptide methionine sulfoxide reductase MsrA 2 HAMAP MF_01401		PRO_0000138586
Sites
	Active site	12	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6GGY3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 6BF0A73224BC98D4	FASTA	177	20,559
	10 20 30 40 50 60 MTKEYATLAG GCFWCMVKPF TSYPGIKSVV SGYSGGHADN PTYEQVCTNQ TGHVEAVQIT 70 80 90 100 110 120 FDPEVTSFEN ILDIYFKTFD PTDDQGQFFD RGESYQPVIF YHDKHQKKAA EFKKQQLNEQ 130 140 150 160 170 GIFKKPVITP IKPYKNFYPA EDYHQDYYKK NPVHYYQYQR GSGRKAFIES HWGNQNA

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MRSA252.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG40434.1.
RefSeq	YP_040839.1. NC_002952.2.
3D structure databases
ProteinModelPortal	Q6GGY3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GGY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000021306; EBSTAP00000020642; EBSTAG00000021305.
GeneID	2861314.
GenomeReviews	Gene locus SAR1437 in contig BX571856_GR.
KEGG	sar:SAR1437.
PATRIC	19546418. VBIStaAur71814_1438.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
GeneTree	EBGT00050000024265.
HOGENOM	HBG748152.
OMA	LVELYWT.
PhylomeDB	Q6GGY3.
ProtClustDB	PRK13014.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR1437-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA2_STAAR

Accession

Primary (citable) accession number: Q6GGY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	July 19, 2004
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program