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Reviewed, UniProtKB/Swiss-Prot Q6GGY1 (DYR_STAAR)

Last modified February 9, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydrofolate reductase
      Short name=DHFR
    EC=1.5.1.3
Gene names
Name: folA
Ordered Locus Names: SAR1439
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis By similarity.

Catalytic activity

5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Sequence similarities

Belongs to the dihydrofolate reductase family.

Contains 1 DHFR (dihydrofolate reductase) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 159158Dihydrofolate reductase
PRO_0000186409

Regions

Domain2 – 157156DHFR
Nucleotide binding7 – 82NADP By similarity
Nucleotide binding15 – 206NADP By similarity
Nucleotide binding44 – 474NADP By similarity
Nucleotide binding63 – 664NADP By similarity
Nucleotide binding93 – 986NADP By similarity
Region6 – 83Substrate binding By similarity

Sites

Binding site281Substrate By similarity
Binding site581Substrate By similarity
Binding site1121Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6GGY1-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 811898409FEAFAAB

FASTA15918,251
        10         20         30         40         50         60 
MTLSILVAHD LQRVIGFENQ LPWHLPNDLK HVKKLSTGHT LVMGRKTFES IGKPLPNRRN 

        70         80         90        100        110        120 
VVLTSDTSFN VEGVDVIHSI EDIYQLPGHV FIFGGQTLFE EMIDKVDDMY ITVIEGKFRG 

       130        140        150 
DTFFPPYTFE DWEVASSVEG KLDEKNTIPH TFLHLIRKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571856 Genomic DNA. Translation: CAG40436.1.
RefSeqYP_040841.1.

3D structure databases

SMRQ6GGY1. Positions 1-159.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6GGY1.

Genome annotation databases

GeneID2859591.
GenomeReviewsGene locus SAR1439 in contig BX571856_GR.
KEGGsar:SAR1439.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0262.
HOGENOMHBG665708.
OMAGLPWHLP.

Enzyme and pathway databases

BioCycSAUR282458:SAR1439-MONOMER.

Family and domain databases

InterProIPR012259. DHFR.
IPR017925. Dihydrofolate_reductase_CS.
IPR001796. Dihydrofolate_reductase_dom.
[Graphical view]
PANTHERPTHR11549:SF1. DHFR. 1 hit.
PfamPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSPR00070. DHFR.
PROSITEPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

BindingDBQ6GGY1.

Entry information

Entry nameDYR_STAAR
AccessionPrimary (citable) accession number: Q6GGY1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 44 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents