Reviewed, UniProtKB/Swiss-Prot Q6GGJ5 (P5CR_STAAR)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase
      Short name=P5C reductase
      Short name=P5CR
    EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	SAR1579

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Pyrroline-5-carboxylate reductase		PRO_0000187301

Sequences

	Sequence		Length	Mass (Da)
	Q6GGJ5-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: BBFB9C07196A9633	FASTA	271	29,840
	10 20 30 40 50 60 MKLVFYGAGN MAQAIFTGII NSSNLDANDI YLTNKSNEQA LKAFAEKLGV NYSYDDATLL 70 80 90 100 110 120 KDADYVFLGT KPHDFDALAT RIKPHITKDN CFISIMAGIP IDYIKQQLEC QNPVARIMPN 130 140 150 160 170 180 TNAQVGHSVT GISFSNNFDP KSKDEINDLV KAFGSVIEVS EDHLHQVTAI TGSGPAFLYH 190 200 210 220 230 240 VFEQYVKAGT KLGLEKEQVE ESIRNLIIGT SKMIERSDLS MAQLRKNITS KGGTTQAGLD 250 260 270 TLSQYDLVSI FEDCLNAAVD RSIELSNIED Q

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG40575.1.
RefSeq	YP_040977.1.
3D structure databases
SMR	Q6GGJ5. Positions 1-271.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GGJ5.
Genome annotation databases
GeneID	2860829.
GenomeReviews	Gene locus SAR1579 in contig BX571856_GR.
KEGG	sar:SAR1579.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0345.
HOGENOM	HBG726602.
OMA	PAYIYYV.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR1579-MONOMER.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P5CR_STAAR

Accession

Primary (citable) accession number: Q6GGJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)