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Q6GGI7

- 6PGD_STAAR

UniProt

Q6GGI7 - 6PGD_STAAR

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Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei101 – 1011NADPBy similarity
Binding sitei101 – 1011SubstrateBy similarity
Active sitei182 – 1821Proton acceptorBy similarity
Active sitei189 – 1891Proton donorBy similarity
Binding sitei190 – 1901SubstrateBy similarity
Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
Binding sitei286 – 2861SubstrateBy similarity
Binding sitei444 – 4441Substrate; shared with dimeric partnerBy similarity
Binding sitei450 – 4501Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 146NADPBy similarity
Nucleotide bindingi32 – 343NADPBy similarity
Nucleotide bindingi73 – 753NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-1588-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:SAR1589
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090055Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi282458.SAR1589.

Structurei

3D structure databases

ProteinModelPortaliQ6GGI7.
SMRiQ6GGI7. Positions 3-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Substrate bindingBy similarity
Regioni185 – 1862Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiDKDGVFH.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GGI7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQQIGVIGL AVMGKNLAWN IESRGYSVSV FNRSSEKTDL MVEESKGKNI
60 70 80 90 100
HPTYSLEEFV NSLEKPRKIL LMVQAGKATD ATIDSLLPLL DDGDILIDGG
110 120 130 140 150
NTNYQDTIRR NKALAQSAIN FIGMGVSGGE IGALTGPSLM PGGQEEAYNK
160 170 180 190 200
VADILDAIAA KAKDGASCVT YIGPNGAGHY VKMVHNGIEY ADMQLIAESY
210 220 230 240 250
AMMKELLGMS HEDIAQTFKD WNAGELESYL IEITGDIFMK LDENKEALVE
260 270 280 290 300
KILDTAGQKG TGKWTSINAL ELGIPLTIIT ESVFARFISS IKEERVNASK
310 320 330 340 350
ELNGPKASFD GDKKDFLEKI RKALYMSKIC SYAQGFAQMR KASEDNEWNL
360 370 380 390 400
KLGDLAMIWR EGCIIRAQFL QKIKDAYDNN PGLQNLLLDP YFKNIVTEYQ
410 420 430 440 450
DALRDVVATG VQNGVPTPGF SSSINYYDSY RAADLPANLI QAQRDYFGAH
460
TYERKDKEGV FHTQWIEE
Length:468
Mass (Da):51,803
Last modified:July 19, 2004 - v1
Checksum:i61A5C2CAF3CCD011
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40584.1.
RefSeqiYP_040985.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40584; CAG40584; SAR1589.
GeneIDi2859935.
KEGGisar:SAR1589.
PATRICi19546726. VBIStaAur71814_1592.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40584.1 .
RefSeqi YP_040985.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GGI7.
SMRi Q6GGI7. Positions 3-467.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1589.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40584 ; CAG40584 ; SAR1589 .
GeneIDi 2859935.
KEGGi sar:SAR1589.
PATRICi 19546726. VBIStaAur71814_1592.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi DKDGVFH.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci SAUR282458:GJA5-1588-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry namei6PGD_STAAR
AccessioniPrimary (citable) accession number: Q6GGI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3