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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:SAR1614
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225981 – 363AminomethyltransferaseAdd BLAST363

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GGG2
SMRiQ6GGG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239381
KOiK00605
OMAiMPVQYPA

Family and domain databases

Gene3Di3.30.1360.120, 2 hits
HAMAPiMF_00259 GcvT, 1 hit
InterProiView protein in InterPro
IPR006223 GCS_T
IPR022903 GCS_T_bac
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GGG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDLKQTPL YQNYVDRGAK IVEFGGWAMP VQFSSIKEEH NAVRYEIGLF
60 70 80 90 100
DVSHMGEIEV TGKDASQFVQ YLLSNDTDNL TTSKALYTAL CNEEGGIIDD
110 120 130 140 150
LVIYKLADDN YLLVVNAANT EKDFNWILKH KEKFDVEVQN VSNQYGQLAI
160 170 180 190 200
QGPKARDLIN QLVDEDVTEM KMFEFKQGVK LFGAIVILSQ SGYTGEDGFE
210 220 230 240 250
IYCNIDDTEK IWDGLLEYNV MPCGLGARDT LRLEAGLPLH GQDLTESITP
260 270 280 290 300
YEGGIAFASK PLIDADFIGK SVLKDQKENG APRRTVGLEL LEKGIARTGY
310 320 330 340 350
EVMDLDGNII GEVTSGTQSP SSGKSIALAM IKRDEFEMGR ELLVQVRKRQ
360
LKAKIVKKNQ IDK
Length:363
Mass (Da):40,457
Last modified:July 19, 2004 - v1
Checksum:iB70849460DAF3BBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG40609.1
RefSeqiWP_000093347.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG40609; CAG40609; SAR1614
KEGGisar:SAR1614

Similar proteinsi

Entry informationi

Entry nameiGCST_STAAR
AccessioniPrimary (citable) accession number: Q6GGG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health