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Q6GG09

- KPYK_STAAR

UniProt

Q6GG09 - KPYK_STAAR

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Protein

Pyruvate kinase

Gene
pyk, SAR1776
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium By similarity.
Potassium By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321Substrate By similarity
Metal bindingi34 – 341Potassium By similarity
Metal bindingi36 – 361Potassium By similarity
Metal bindingi66 – 661Potassium By similarity
Metal bindingi67 – 671Potassium; via carbonyl oxygen By similarity
Sitei219 – 2191Transition state stabilizer By similarity
Metal bindingi221 – 2211Magnesium By similarity
Binding sitei244 – 2441Substrate; via amide nitrogen By similarity
Metal bindingi245 – 2451Magnesium By similarity
Binding sitei245 – 2451Substrate; via amide nitrogen By similarity
Binding sitei277 – 2771Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-1772-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:SAR1776
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Pyruvate kinasePRO_0000294130Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi282458.SAR1776.

Structurei

Secondary structure

1
585
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96
Helixi12 – 143
Helixi17 – 259
Beta strandi28 – 347
Helixi40 – 5617
Beta strandi62 – 665
Beta strandi72 – 743
Beta strandi80 – 834
Beta strandi89 – 957
Beta strandi101 – 1077
Helixi111 – 1144
Beta strandi120 – 1234
Turni124 – 1274
Beta strandi128 – 1369
Turni137 – 1404
Beta strandi141 – 1466
Beta strandi151 – 1533
Beta strandi157 – 1593
Beta strandi161 – 1633
Helixi172 – 18312
Beta strandi187 – 1915
Helixi197 – 20913
Beta strandi215 – 2184
Helixi223 – 2275
Helixi229 – 2357
Beta strandi239 – 2424
Helixi243 – 2497
Helixi252 – 2543
Helixi255 – 26915
Beta strandi273 – 2808
Helixi281 – 2833
Beta strandi286 – 2883
Helixi291 – 30313
Beta strandi306 – 3105
Helixi312 – 3154
Helixi321 – 33616
Helixi340 – 35011
Helixi355 – 37016
Beta strandi373 – 3786
Beta strandi380 – 3823
Helixi383 – 3908
Beta strandi394 – 4029
Helixi404 – 4118
Beta strandi413 – 4208
Helixi427 – 44014
Beta strandi449 – 4546
Turni458 – 4603
Beta strandi466 – 4716
Beta strandi476 – 4783
Beta strandi480 – 4845
Beta strandi486 – 4938
Helixi497 – 5004
Beta strandi501 – 5033
Beta strandi506 – 5138
Turni517 – 5193
Helixi520 – 5234
Beta strandi526 – 5338
Beta strandi536 – 5383
Helixi539 – 5468
Beta strandi551 – 5533
Helixi558 – 5614
Beta strandi567 – 5715
Turni572 – 5754
Beta strandi576 – 5805

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T05X-ray3.05A/B/C/D1-585[»]
3T07X-ray3.30A/B/C/D1-585[»]
3T0TX-ray3.10A/B/C/D1-585[»]
ProteinModelPortaliQ6GG09.
SMRiQ6GG09. Positions 2-585.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.
In the C-terminal section; belongs to the PEP-utilizing enzyme family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiGTHEEHK.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProiIPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GG09-1 [UniParc]FASTAAdd to Basket

« Hide

MRKTKIVCTI GPASESEEMI EKLINAGMNV ARLNFSHGSH EEHKGRIDTI    50
RKVAKRLDKI VAILLDTKGP EIRTHNMKDG IIELERGNEV IVSMNEVEGT 100
PEKFSVTYEN LINDVQVGSY ILLDDGLIEL QVKDIDHAKK EVKCDILNSG 150
ELKNKKGVNL PGVRVSLPGI TEKDAEDIRF GIKENVDFIA ASFVRRPSDV 200
LEIREILEEQ KANISVFPKI ENQEGIDNIE EILEVSDGLM VARGDMGVEI 250
PPEKVPMVQK DLIRQCNKLG KPVITATQML DSMQRNPRAT RAEASDVANA 300
IYDGTDAVML SGETAAGLYP EEAVKTMRNI AVSAEAAQDY KKLLSDRTKL 350
VETSLVNAIG ISVAHTALNL NVKAIVAATE SGSTARTISK YRPHSDIIAV 400
TPSEETARQC SIVWGVQPVV KKGRKSTDAL LNNAVATAVE TGRVTNGDLI 450
IITAGVPTGE TGTTNMMKIH LVGDEIANGQ GIGRGSVVGT TLVAETVKDL 500
EGKDLSDKVI VTNSIDETFV PYVEKALGLI TEENGITSPS AIVGLEKGIP 550
TVVGVEKAVK NISNNVLVTI DAAQGKIFEG YANVL 585
Length:585
Mass (Da):63,142
Last modified:July 19, 2004 - v1
Checksum:i87D790B356585362
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40767.1.
RefSeqiYP_041163.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40767; CAG40767; SAR1776.
GeneIDi2861244.
KEGGisar:SAR1776.
PATRICi19547102. VBIStaAur71814_1780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40767.1 .
RefSeqi YP_041163.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T05 X-ray 3.05 A/B/C/D 1-585 [» ]
3T07 X-ray 3.30 A/B/C/D 1-585 [» ]
3T0T X-ray 3.10 A/B/C/D 1-585 [» ]
ProteinModelPortali Q6GG09.
SMRi Q6GG09. Positions 2-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1776.

Chemistry

ChEMBLi CHEMBL2189162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40767 ; CAG40767 ; SAR1776 .
GeneIDi 2861244.
KEGGi sar:SAR1776.
PATRICi 19547102. VBIStaAur71814_1780.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi GTHEEHK.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci SAUR282458:GJA5-1772-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProi IPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiKPYK_STAAR
AccessioniPrimary (citable) accession number: Q6GG09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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