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Q6GG09

- KPYK_STAAR

UniProt

Q6GG09 - KPYK_STAAR

Protein

Pyruvate kinase

Gene

pyk

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.By similarity
    Potassium.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei32 – 321SubstrateBy similarity
    Metal bindingi34 – 341PotassiumBy similarity
    Metal bindingi36 – 361PotassiumBy similarity
    Metal bindingi66 – 661PotassiumBy similarity
    Metal bindingi67 – 671Potassium; via carbonyl oxygenBy similarity
    Sitei219 – 2191Transition state stabilizerBy similarity
    Metal bindingi221 – 2211MagnesiumBy similarity
    Binding sitei244 – 2441Substrate; via amide nitrogenBy similarity
    Metal bindingi245 – 2451MagnesiumBy similarity
    Binding sitei245 – 2451Substrate; via amide nitrogenBy similarity
    Binding sitei277 – 2771SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    BioCyciSAUR282458:GJA5-1772-MONOMER.
    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    Ordered Locus Names:SAR1776
    OrganismiStaphylococcus aureus (strain MRSA252)
    Taxonomic identifieri282458 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000596: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 585585Pyruvate kinasePRO_0000294130Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi282458.SAR1776.

    Structurei

    Secondary structure

    1
    585
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi4 – 96
    Helixi12 – 143
    Helixi17 – 259
    Beta strandi28 – 347
    Helixi40 – 5617
    Beta strandi62 – 665
    Beta strandi72 – 743
    Beta strandi80 – 834
    Beta strandi89 – 957
    Beta strandi101 – 1077
    Helixi111 – 1144
    Beta strandi120 – 1234
    Turni124 – 1274
    Beta strandi128 – 1369
    Turni137 – 1404
    Beta strandi141 – 1466
    Beta strandi151 – 1533
    Beta strandi157 – 1593
    Beta strandi161 – 1633
    Helixi172 – 18312
    Beta strandi187 – 1915
    Helixi197 – 20913
    Beta strandi215 – 2184
    Helixi223 – 2275
    Helixi229 – 2357
    Beta strandi239 – 2424
    Helixi243 – 2497
    Helixi252 – 2543
    Helixi255 – 26915
    Beta strandi273 – 2808
    Helixi281 – 2833
    Beta strandi286 – 2883
    Helixi291 – 30313
    Beta strandi306 – 3105
    Helixi312 – 3154
    Helixi321 – 33616
    Helixi340 – 35011
    Helixi355 – 37016
    Beta strandi373 – 3786
    Beta strandi380 – 3823
    Helixi383 – 3908
    Beta strandi394 – 4029
    Helixi404 – 4118
    Beta strandi413 – 4208
    Helixi427 – 44014
    Beta strandi449 – 4546
    Turni458 – 4603
    Beta strandi466 – 4716
    Beta strandi476 – 4783
    Beta strandi480 – 4845
    Beta strandi486 – 4938
    Helixi497 – 5004
    Beta strandi501 – 5033
    Beta strandi506 – 5138
    Turni517 – 5193
    Helixi520 – 5234
    Beta strandi526 – 5338
    Beta strandi536 – 5383
    Helixi539 – 5468
    Beta strandi551 – 5533
    Helixi558 – 5614
    Beta strandi567 – 5715
    Turni572 – 5754
    Beta strandi576 – 5805

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3T05X-ray3.05A/B/C/D1-585[»]
    3T07X-ray3.30A/B/C/D1-585[»]
    3T0TX-ray3.10A/B/C/D1-585[»]
    ProteinModelPortaliQ6GG09.
    SMRiQ6GG09. Positions 2-585.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated
    In the C-terminal section; belongs to the PEP-utilizing enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    HOGENOMiHOG000021559.
    KOiK00873.
    OMAiGTHEEHK.
    OrthoDBiEOG6GBMB0.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    3.50.30.10. 1 hit.
    InterProiIPR008279. PEP-util_enz_mobile_dom.
    IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00391. PEP-utilizers. 1 hit.
    PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52009. SSF52009. 1 hit.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6GG09-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKTKIVCTI GPASESEEMI EKLINAGMNV ARLNFSHGSH EEHKGRIDTI    50
    RKVAKRLDKI VAILLDTKGP EIRTHNMKDG IIELERGNEV IVSMNEVEGT 100
    PEKFSVTYEN LINDVQVGSY ILLDDGLIEL QVKDIDHAKK EVKCDILNSG 150
    ELKNKKGVNL PGVRVSLPGI TEKDAEDIRF GIKENVDFIA ASFVRRPSDV 200
    LEIREILEEQ KANISVFPKI ENQEGIDNIE EILEVSDGLM VARGDMGVEI 250
    PPEKVPMVQK DLIRQCNKLG KPVITATQML DSMQRNPRAT RAEASDVANA 300
    IYDGTDAVML SGETAAGLYP EEAVKTMRNI AVSAEAAQDY KKLLSDRTKL 350
    VETSLVNAIG ISVAHTALNL NVKAIVAATE SGSTARTISK YRPHSDIIAV 400
    TPSEETARQC SIVWGVQPVV KKGRKSTDAL LNNAVATAVE TGRVTNGDLI 450
    IITAGVPTGE TGTTNMMKIH LVGDEIANGQ GIGRGSVVGT TLVAETVKDL 500
    EGKDLSDKVI VTNSIDETFV PYVEKALGLI TEENGITSPS AIVGLEKGIP 550
    TVVGVEKAVK NISNNVLVTI DAAQGKIFEG YANVL 585
    Length:585
    Mass (Da):63,142
    Last modified:July 19, 2004 - v1
    Checksum:i87D790B356585362
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40767.1.
    RefSeqiYP_041163.1. NC_002952.2.

    Genome annotation databases

    EnsemblBacteriaiCAG40767; CAG40767; SAR1776.
    GeneIDi2861244.
    KEGGisar:SAR1776.
    PATRICi19547102. VBIStaAur71814_1780.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG40767.1 .
    RefSeqi YP_041163.1. NC_002952.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3T05 X-ray 3.05 A/B/C/D 1-585 [» ]
    3T07 X-ray 3.30 A/B/C/D 1-585 [» ]
    3T0T X-ray 3.10 A/B/C/D 1-585 [» ]
    ProteinModelPortali Q6GG09.
    SMRi Q6GG09. Positions 2-585.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282458.SAR1776.

    Chemistry

    ChEMBLi CHEMBL2189162.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG40767 ; CAG40767 ; SAR1776 .
    GeneIDi 2861244.
    KEGGi sar:SAR1776.
    PATRICi 19547102. VBIStaAur71814_1780.

    Phylogenomic databases

    eggNOGi COG0469.
    HOGENOMi HOG000021559.
    KOi K00873.
    OMAi GTHEEHK.
    OrthoDBi EOG6GBMB0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .
    BioCyci SAUR282458:GJA5-1772-MONOMER.

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    3.50.30.10. 1 hit.
    InterProi IPR008279. PEP-util_enz_mobile_dom.
    IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00391. PEP-utilizers. 1 hit.
    PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52009. SSF52009. 1 hit.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MRSA252.

    Entry informationi

    Entry nameiKPYK_STAAR
    AccessioniPrimary (citable) accession number: Q6GG09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3