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Q6GG09

- KPYK_STAAR

UniProt

Q6GG09 - KPYK_STAAR

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Protein

Pyruvate kinase

Gene

pyk

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei32 – 321SubstrateBy similarity
Metal bindingi34 – 341PotassiumBy similarity
Metal bindingi36 – 361PotassiumBy similarity
Metal bindingi66 – 661PotassiumBy similarity
Metal bindingi67 – 671Potassium; via carbonyl oxygenBy similarity
Sitei219 – 2191Transition state stabilizerBy similarity
Metal bindingi221 – 2211MagnesiumBy similarity
Binding sitei244 – 2441Substrate; via amide nitrogenBy similarity
Metal bindingi245 – 2451MagnesiumBy similarity
Binding sitei245 – 2451Substrate; via amide nitrogenBy similarity
Binding sitei277 – 2771SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-1772-MONOMER.
UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:pyk
Ordered Locus Names:SAR1776
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 585585Pyruvate kinasePRO_0000294130Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi282458.SAR1776.

Structurei

Secondary structure

1
585
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 96Combined sources
Helixi12 – 143Combined sources
Helixi17 – 259Combined sources
Beta strandi28 – 347Combined sources
Helixi40 – 5617Combined sources
Beta strandi62 – 665Combined sources
Beta strandi72 – 743Combined sources
Beta strandi80 – 834Combined sources
Beta strandi89 – 957Combined sources
Beta strandi101 – 1077Combined sources
Helixi111 – 1144Combined sources
Beta strandi120 – 1234Combined sources
Turni124 – 1274Combined sources
Beta strandi128 – 1369Combined sources
Turni137 – 1404Combined sources
Beta strandi141 – 1466Combined sources
Beta strandi151 – 1533Combined sources
Beta strandi157 – 1593Combined sources
Beta strandi161 – 1633Combined sources
Helixi172 – 18312Combined sources
Beta strandi187 – 1915Combined sources
Helixi197 – 20913Combined sources
Beta strandi215 – 2184Combined sources
Helixi223 – 2275Combined sources
Helixi229 – 2357Combined sources
Beta strandi239 – 2424Combined sources
Helixi243 – 2497Combined sources
Helixi252 – 2543Combined sources
Helixi255 – 26915Combined sources
Beta strandi273 – 2808Combined sources
Helixi281 – 2833Combined sources
Beta strandi286 – 2883Combined sources
Helixi291 – 30313Combined sources
Beta strandi306 – 3105Combined sources
Helixi312 – 3154Combined sources
Helixi321 – 33616Combined sources
Helixi340 – 35011Combined sources
Helixi355 – 37016Combined sources
Beta strandi373 – 3786Combined sources
Beta strandi380 – 3823Combined sources
Helixi383 – 3908Combined sources
Beta strandi394 – 4029Combined sources
Helixi404 – 4118Combined sources
Beta strandi413 – 4208Combined sources
Helixi427 – 44014Combined sources
Beta strandi449 – 4546Combined sources
Turni458 – 4603Combined sources
Beta strandi466 – 4716Combined sources
Beta strandi476 – 4783Combined sources
Beta strandi480 – 4845Combined sources
Beta strandi486 – 4938Combined sources
Helixi497 – 5004Combined sources
Beta strandi501 – 5033Combined sources
Beta strandi506 – 5138Combined sources
Turni517 – 5193Combined sources
Helixi520 – 5234Combined sources
Beta strandi526 – 5338Combined sources
Beta strandi536 – 5383Combined sources
Helixi539 – 5468Combined sources
Beta strandi551 – 5533Combined sources
Helixi558 – 5614Combined sources
Beta strandi567 – 5715Combined sources
Turni572 – 5754Combined sources
Beta strandi576 – 5805Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3T05X-ray3.05A/B/C/D1-585[»]
3T07X-ray3.30A/B/C/D1-585[»]
3T0TX-ray3.10A/B/C/D1-585[»]
ProteinModelPortaliQ6GG09.
SMRiQ6GG09. Positions 2-585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated
In the C-terminal section; belongs to the PEP-utilizing enzyme family.Curated

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiGTHEEHK.
OrthoDBiEOG6GBMB0.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProiIPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GG09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKTKIVCTI GPASESEEMI EKLINAGMNV ARLNFSHGSH EEHKGRIDTI
60 70 80 90 100
RKVAKRLDKI VAILLDTKGP EIRTHNMKDG IIELERGNEV IVSMNEVEGT
110 120 130 140 150
PEKFSVTYEN LINDVQVGSY ILLDDGLIEL QVKDIDHAKK EVKCDILNSG
160 170 180 190 200
ELKNKKGVNL PGVRVSLPGI TEKDAEDIRF GIKENVDFIA ASFVRRPSDV
210 220 230 240 250
LEIREILEEQ KANISVFPKI ENQEGIDNIE EILEVSDGLM VARGDMGVEI
260 270 280 290 300
PPEKVPMVQK DLIRQCNKLG KPVITATQML DSMQRNPRAT RAEASDVANA
310 320 330 340 350
IYDGTDAVML SGETAAGLYP EEAVKTMRNI AVSAEAAQDY KKLLSDRTKL
360 370 380 390 400
VETSLVNAIG ISVAHTALNL NVKAIVAATE SGSTARTISK YRPHSDIIAV
410 420 430 440 450
TPSEETARQC SIVWGVQPVV KKGRKSTDAL LNNAVATAVE TGRVTNGDLI
460 470 480 490 500
IITAGVPTGE TGTTNMMKIH LVGDEIANGQ GIGRGSVVGT TLVAETVKDL
510 520 530 540 550
EGKDLSDKVI VTNSIDETFV PYVEKALGLI TEENGITSPS AIVGLEKGIP
560 570 580
TVVGVEKAVK NISNNVLVTI DAAQGKIFEG YANVL
Length:585
Mass (Da):63,142
Last modified:July 19, 2004 - v1
Checksum:i87D790B356585362
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40767.1.
RefSeqiYP_041163.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40767; CAG40767; SAR1776.
GeneIDi2861244.
KEGGisar:SAR1776.
PATRICi19547102. VBIStaAur71814_1780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG40767.1 .
RefSeqi YP_041163.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3T05 X-ray 3.05 A/B/C/D 1-585 [» ]
3T07 X-ray 3.30 A/B/C/D 1-585 [» ]
3T0T X-ray 3.10 A/B/C/D 1-585 [» ]
ProteinModelPortali Q6GG09.
SMRi Q6GG09. Positions 2-585.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1776.

Chemistry

BindingDBi Q6GG09.
ChEMBLi CHEMBL2189162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40767 ; CAG40767 ; SAR1776 .
GeneIDi 2861244.
KEGGi sar:SAR1776.
PATRICi 19547102. VBIStaAur71814_1780.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi GTHEEHK.
OrthoDBi EOG6GBMB0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .
BioCyci SAUR282458:GJA5-1772-MONOMER.

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
3.50.30.10. 1 hit.
InterProi IPR008279. PEP-util_enz_mobile_dom.
IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00391. PEP-utilizers. 1 hit.
PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52009. SSF52009. 1 hit.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiKPYK_STAAR
AccessioniPrimary (citable) accession number: Q6GG09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3