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Q6GFH6

- PTPA_STAAR

UniProt

Q6GFH6 - PTPA_STAAR

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Protein

Low molecular weight protein-tyrosine-phosphatase PtpA

Gene
ptpA, SAR1971
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Dephosphorylates the phosphotyrosine-containing proteins By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Nucleophile By similarity
Active sitei14 – 141 By similarity
Active sitei120 – 1201Proton donor By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2005-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase PtpA (EC:3.1.3.48)
Alternative name(s):
Phosphotyrosine phosphatase A
Short name:
PTPase A
Gene namesi
Name:ptpA
Ordered Locus Names:SAR1971
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Low molecular weight protein-tyrosine-phosphatase PtpAPRO_0000300659Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi282458.SAR1971.

Structurei

3D structure databases

ProteinModelPortaliQ6GFH6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273094.
KOiK01104.
OMAiDSAGTHD.
OrthoDBiEOG6MH5JB.

Family and domain databases

InterProiIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717. PTHR11717. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GFH6-1 [UniParc]FASTAAdd to Basket

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MVDVAFVCLG NICRSPMAEA IMRQRLKDRN IQDIKVHSRG TGSWNLGEPP    50
HEGTQKILNK HNIPFDGMIS ELFEATDDFD YIVAMDQSNV DNIKSINPNL 100
KGQLFKLLEF SNMEESDVPD PYYTNNFEGV YDMVLSSCDN LIDYIVKDAN 150
LKEG 154
Length:154
Mass (Da):17,482
Last modified:July 19, 2004 - v1
Checksum:i70D8103B9825B1E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40958.1.
RefSeqiYP_041346.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG40958; CAG40958; SAR1971.
GeneIDi2861213.
KEGGisar:SAR1971.
PATRICi19547577. VBIStaAur71814_1978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG40958.1 .
RefSeqi YP_041346.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GFH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR1971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG40958 ; CAG40958 ; SAR1971 .
GeneIDi 2861213.
KEGGi sar:SAR1971.
PATRICi 19547577. VBIStaAur71814_1978.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273094.
KOi K01104.
OMAi DSAGTHD.
OrthoDBi EOG6MH5JB.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-2005-MONOMER.

Family and domain databases

InterProi IPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717. PTHR11717. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
PRINTSi PR00719. LMWPTPASE.
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiPTPA_STAAR
AccessioniPrimary (citable) accession number: Q6GFH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi