Staphylococcal complement inhibitor precursor - Staphylococcus aureus (strain MRSA252)

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Q6GFB4 (SCIN_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Staphylococcal complement inhibitor
Short name=SCIN

Gene names

Name:	scn
Ordered Locus Names:	SAR2035

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the SCIN family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Secreted
Domain	Signal
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

31

Potential

Chain

85

Staphylococcal complement inhibitor

PRO_0000319868

Regions

Region

18

Essential for activity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

116

Helix Strand Turn

Sequences

Sequence

Length

Mass (Da)

Tools

Q6GFB4 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 6C30E481973D19E9
Show »

116

13,067

        10         20         30         40         50         60 
MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL KSLLDELNVN 

        70         80         90        100        110 
ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ LQKIYNEIDE ALKSKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MRSA252.
[2]	"Staphylococcal complement inhibitor: structure and active sites." Rooijakkers S.H.M., Milder F.J., Bardoel B.W., Ruyken M., van Strijp J.A.G., Gros P. J. Immunol. 179:2989-2998(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 32-113.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BX571856 Genomic DNA. Translation: CAG41021.1.

RefSeq

YP_041408.1. NC_002952.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2QFF	X-ray	1.80	A	32-113	[»]
2WIN	X-ray	3.90	M/N/P/Q	32-116	[»]

ProteinModelPortal

SMR

Q6GFB4. Positions 33-116.

ModBase

Protocols and materials databases

StructuralBiologyKnowledgebase

Genome annotation databases

EnsemblBacteria

CAG41021; CAG41021; SAR2035.

GeneID

KEGG

PATRIC

19547717. VBIStaAur71814_2049.

Organism-specific databases

CMR

Phylogenomic databases

HOGENOM

KO

OMA

ProtClustDB

Enzyme and pathway databases

BioCyc

SAUR282458:GJA5-2067-MONOMER.

Family and domain databases

InterPro

IPR021612. CompInhib_SCIN.
[Graphical view]

Pfam

PF11546. CompInhib_SCIN. 1 hit.
[Graphical view]

ProtoNet

Other

EvolutionaryTrace

Entry information

Entry name

SCIN_STAAR

Accession

Primary (citable) accession number: Q6GFB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents