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Q6GFB4 (SCIN_STAAR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Staphylococcal complement inhibitor

Short name=SCIN
Gene names
Name:scn
Ordered Locus Names:SAR2035
OrganismStaphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]
Taxonomic identifier282458 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the SCIN family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentSecreted
   DomainSignal
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3131 Potential
Chain32 – 11685Staphylococcal complement inhibitor
PRO_0000319868

Regions

Region62 – 7918Essential for activity

Secondary structure

.......... 116
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q6GFB4 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 6C30E481973D19E9

FASTA11613,067
        10         20         30         40         50         60 
MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL KSLLDELNVN 

        70         80         90        100        110 
ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ LQKIYNEIDE ALKSKY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX571856 Genomic DNA. Translation: CAG41021.1.
RefSeqYP_041408.1. NC_002952.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2QFFX-ray1.80A32-113[»]
2WINX-ray3.90M/N/P/Q32-116[»]
ProteinModelPortalQ6GFB4.
SMRQ6GFB4. Positions 33-116.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG41021; CAG41021; SAR2035.
GeneID2861485.
KEGGsar:SAR2035.
PATRIC19547717. VBIStaAur71814_2049.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000232739.
KOK14199.
OMAITANEYY.
OrthoDBEOG6716QD.

Enzyme and pathway databases

BioCycSAUR282458:GJA5-2067-MONOMER.

Family and domain databases

InterProIPR021612. CompInhib_SCIN.
[Graphical view]
PfamPF11546. CompInhib_SCIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ6GFB4.
PROQ6GFB4.

Entry information

Entry nameSCIN_STAAR
AccessionPrimary (citable) accession number: Q6GFB4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references