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Protein

Staphylococcal complement inhibitor

Gene

scn

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (By similarity).By similarity

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Virulence

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylococcal complement inhibitor
Short name:
SCIN
Gene namesi
Name:scn
Ordered Locus Names:SAR2035
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 11685Staphylococcal complement inhibitorPRO_0000319868Add
BLAST

Structurei

Secondary structure

1
116
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi41 – 5414Combined sources
Helixi57 – 637Combined sources
Helixi64 – 663Combined sources
Helixi69 – 8820Combined sources
Helixi91 – 11222Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QFFX-ray1.80A32-113[»]
2WINX-ray3.90M/N/P/Q32-116[»]
ProteinModelPortaliQ6GFB4.
SMRiQ6GFB4. Positions 33-116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6GFB4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 7918Essential for activityAdd
BLAST

Sequence similaritiesi

Belongs to the SCIN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232739.
KOiK14199.
OMAiITANEYY.
OrthoDBiEOG6716QD.

Family and domain databases

InterProiIPR021612. SCIN.
[Graphical view]
PfamiPF11546. CompInhib_SCIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GFB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL
60 70 80 90 100
KSLLDELNVN ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ
110
LQKIYNEIDE ALKSKY
Length:116
Mass (Da):13,067
Last modified:July 19, 2004 - v1
Checksum:i6C30E481973D19E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG41021.1.
RefSeqiYP_041408.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41021; CAG41021; SAR2035.
GeneIDi2861485.
KEGGisar:SAR2035.
PATRICi19547717. VBIStaAur71814_2049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG41021.1.
RefSeqiYP_041408.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QFFX-ray1.80A32-113[»]
2WINX-ray3.90M/N/P/Q32-116[»]
ProteinModelPortaliQ6GFB4.
SMRiQ6GFB4. Positions 33-116.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG41021; CAG41021; SAR2035.
GeneIDi2861485.
KEGGisar:SAR2035.
PATRICi19547717. VBIStaAur71814_2049.

Phylogenomic databases

HOGENOMiHOG000232739.
KOiK14199.
OMAiITANEYY.
OrthoDBiEOG6716QD.

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2067-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ6GFB4.
PROiQ6GFB4.

Family and domain databases

InterProiIPR021612. SCIN.
[Graphical view]
PfamiPF11546. CompInhib_SCIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 32-113.

Entry informationi

Entry nameiSCIN_STAAR
AccessioniPrimary (citable) accession number: Q6GFB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.