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Protein

Staphylococcal complement inhibitor

Gene

scn

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylococcal complement inhibitor
Short name:
SCIN
Gene namesi
Name:scn
Ordered Locus Names:SAR2035
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000031986832 – 116Staphylococcal complement inhibitorAdd BLAST85

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 54Combined sources14
Helixi57 – 63Combined sources7
Helixi64 – 66Combined sources3
Helixi69 – 88Combined sources20
Helixi91 – 112Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFFX-ray1.80A32-113[»]
2WINX-ray3.90M/N/P/Q32-116[»]
ProteinModelPortaliQ6GFB4.
SMRiQ6GFB4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6GFB4.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 79Essential for activityAdd BLAST18

Sequence similaritiesi

Belongs to the SCIN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232739.
KOiK14199.

Family and domain databases

InterProiIPR021612. SCIN.
[Graphical view]
PfamiPF11546. CompInhib_SCIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GFB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL
60 70 80 90 100
KSLLDELNVN ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ
110
LQKIYNEIDE ALKSKY
Length:116
Mass (Da):13,067
Last modified:July 19, 2004 - v1
Checksum:i6C30E481973D19E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG41021.1.
RefSeqiWP_000702263.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41021; CAG41021; SAR2035.
KEGGisar:SAR2035.
PATRICi19547717. VBIStaAur71814_2049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG41021.1.
RefSeqiWP_000702263.1. NC_002952.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFFX-ray1.80A32-113[»]
2WINX-ray3.90M/N/P/Q32-116[»]
ProteinModelPortaliQ6GFB4.
SMRiQ6GFB4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG41021; CAG41021; SAR2035.
KEGGisar:SAR2035.
PATRICi19547717. VBIStaAur71814_2049.

Phylogenomic databases

HOGENOMiHOG000232739.
KOiK14199.

Miscellaneous databases

EvolutionaryTraceiQ6GFB4.
PROiQ6GFB4.

Family and domain databases

InterProiIPR021612. SCIN.
[Graphical view]
PfamiPF11546. CompInhib_SCIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCIN_STAAR
AccessioniPrimary (citable) accession number: Q6GFB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.