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Protein

Staphylococcal complement inhibitor

Gene

scn

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylococcal complement inhibitor
Short name:
SCIN
Gene namesi
Name:scn
Ordered Locus Names:SAR2035
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000031986832 – 116Staphylococcal complement inhibitorAdd BLAST85

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 54Combined sources14
Helixi57 – 63Combined sources7
Helixi64 – 66Combined sources3
Helixi69 – 88Combined sources20
Helixi91 – 112Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFFX-ray1.80A32-113[»]
2WINX-ray3.90M/N/P/Q32-116[»]
5M6WX-ray6.00N/Q32-116[»]
ProteinModelPortaliQ6GFB4
SMRiQ6GFB4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6GFB4

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 79Essential for activityAdd BLAST18

Sequence similaritiesi

Belongs to the SCIN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000232739
KOiK14199

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
InterProiView protein in InterPro
IPR029048 HSP70_C_sf
IPR021612 SCIN
PfamiView protein in Pfam
PF11546 CompInhib_SCIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GFB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRKSILAG TLAIVLASPL VTNLDKNEAQ ASTSLPTSNE YQNEKLANEL
60 70 80 90 100
KSLLDELNVN ELATGSLNTY YKRTIKISGQ KAMYALKSKD FKKMSEAKYQ
110
LQKIYNEIDE ALKSKY
Length:116
Mass (Da):13,067
Last modified:July 19, 2004 - v1
Checksum:i6C30E481973D19E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG41021.1
RefSeqiWP_000702263.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG41021; CAG41021; SAR2035
KEGGisar:SAR2035

Similar proteinsi

Entry informationi

Entry nameiSCIN_STAAR
AccessioniPrimary (citable) accession number: Q6GFB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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