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Q6GEY2

- THID_STAAR

UniProt

Q6GEY2 - THID_STAAR

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Protein
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
Gene
thiD, SAR2182
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P By similarity.

Catalytic activityi

ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-5-phosphonooxymethyl-2-methylpyrimidine.
ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hydroxymethylpyrimidine kinase activity Source: UniProtKB-EC
  3. phosphomethylpyrimidine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2214-MONOMER.
UniPathwayiUPA00060; UER00137.
UPA00060; UER00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC:2.7.1.49, EC:2.7.4.7)
Alternative name(s):
Hydroxymethylpyrimidine kinase
Short name:
HMP kinase
Hydroxymethylpyrimidine phosphate kinase
Short name:
HMP-P kinase
Short name:
HMP-phosphate kinase
Short name:
HMPP kinase
Gene namesi
Name:thiD
Ordered Locus Names:SAR2182
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
PRO_0000192030Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi282458.SAR2182.

Structurei

3D structure databases

ProteinModelPortaliQ6GEY2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.

Phylogenomic databases

eggNOGiCOG0351.
HOGENOMiHOG000225273.
KOiK00941.
OMAiTNHWAYS.
OrthoDBiEOG6XWV53.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GEY2-1 [UniParc]FASTAAdd to Basket

« Hide

MIKPKIALTI AGTDPTGGAG VMADLKSFHS CGVYGMGVVT SIVAQNTLGV    50
QHIHNLNHQW VDEQLDSVFN DTLPHAIKTG MIATADTMET IRHYLMQHES 100
IPYVIDPVML AKSGDSLMDN NTKQNLQHTL LPLADVVTPN LPEAEEITGL 150
TIDSEEKIMQ AGRIFINEIG SKGVIIKGGH SNDADIAKDY LFTKEGVQTF 200
ENERFKTKHT HGTGCTFSAV ITAELAKGRP LFEAVHKAKK FISMSIQYTP 250
EIGRGRGPVN HFAYLKKEGL DDELSK 276
Length:276
Mass (Da):30,212
Last modified:July 19, 2004 - v1
Checksum:i0A09A048CB42D752
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41162.1.
RefSeqiYP_041541.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41162; CAG41162; SAR2182.
GeneIDi2859525.
KEGGisar:SAR2182.
PATRICi19548001. VBIStaAur71814_2186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41162.1 .
RefSeqi YP_041541.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GEY2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 282458.SAR2182.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG41162 ; CAG41162 ; SAR2182 .
GeneIDi 2859525.
KEGGi sar:SAR2182.
PATRICi 19548001. VBIStaAur71814_2186.

Phylogenomic databases

eggNOGi COG0351.
HOGENOMi HOG000225273.
KOi K00941.
OMAi TNHWAYS.
OrthoDBi EOG6XWV53.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00137 .
UPA00060 ; UER00138 .
BioCyci SAUR282458:GJA5-2214-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
InterProi IPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF08543. Phos_pyr_kin. 1 hit.
[Graphical view ]
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00097. HMP-P_kinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiTHID_STAAR
AccessioniPrimary (citable) accession number: Q6GEY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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