UniProtKB - Q6GEV6 (KITH_STAAR)
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Protein
Thymidine kinase
Gene
tdk
Organism
Staphylococcus aureus (strain MRSA252)
Status
Functioni
Catalytic activityi
ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 89 | Proton acceptorUniRule annotation | 1 | |
Metal bindingi | 145 | ZincUniRule annotation | 1 | |
Metal bindingi | 148 | ZincUniRule annotation | 1 | |
Metal bindingi | 183 | ZincUniRule annotation | 1 | |
Metal bindingi | 186 | ZincUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 15 – 22 | ATPUniRule annotation | 8 | |
Nucleotide bindingi | 88 – 91 | ATPUniRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- thymidine kinase activity Source: UniProtKB-EC
GO - Biological processi
- DNA biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | DNA synthesis |
Ligand | ATP-binding, Metal-binding, Nucleotide-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:tdkUniRule annotation Ordered Locus Names:SAR2207 |
Organismi | Staphylococcus aureus (strain MRSA252) |
Taxonomic identifieri | 282458 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000175021 | 1 – 199 | Thymidine kinaseAdd BLAST | 199 |
Interactioni
Subunit structurei
Homotetramer.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | Q6GEV6. |
SMRi | Q6GEV6. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the thymidine kinase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000076390. |
KOi | K00857. |
OMAi | CAGLDQD. |
Family and domain databases
HAMAPi | MF_00124. Thymidine_kinase. 1 hit. |
InterProi | View protein in InterPro IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. |
PANTHERi | PTHR11441. PTHR11441. 1 hit. |
Pfami | View protein in Pfam PF00265. TK. 1 hit. |
PIRSFi | PIRSF035805. TK_cell. 1 hit. |
SUPFAMi | SSF52540. SSF52540. 1 hit. |
PROSITEi | View protein in PROSITE PS00603. TK_CELLULAR_TYPE. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6GEV6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY
60 70 80 90 100
HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI
110 120 130 140 150
VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS
160 170 180 190
SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571856 Genomic DNA. Translation: CAG41188.1. |
RefSeqi | WP_000273356.1. NC_002952.2. |
Genome annotation databases
EnsemblBacteriai | CAG41188; CAG41188; SAR2207. |
KEGGi | sar:SAR2207. |
Similar proteinsi
Entry informationi
Entry namei | KITH_STAAR | |
Accessioni | Q6GEV6Primary (citable) accession number: Q6GEV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | March 28, 2018 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |