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Protein

Galactose-6-phosphate isomerase subunit LacB

Gene

lacB

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacB (lacB), Galactose-6-phosphate isomerase subunit LacA (lacA)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2325-MONOMER.
UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacBUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacBUniRule annotation
Ordered Locus Names:SAR2285
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Galactose-6-phosphate isomerase subunit LacBPRO_0000208138Add
BLAST

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GEN5.
SMRiQ6GEN5. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226301.
KOiK01819.
OMAiETHHANQ.
OrthoDBiEOG679TJ4.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01556. LacB.
InterProiIPR004784. LacB.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01119. lacB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6GEN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIALGCDHI VTDTKMRVSE FLKSKGHEVI DVGTYDFTRT HYPIFGKKVG
60 70 80 90 100
EQVVSGNADL GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN
110 120 130 140 150
ANVIGFGGRI IGELLMCDII DAFINAEYKP TEENKKLIAK IKHLETSNAD
160 170
QADPHFFDEF LEKWDRGEYH D
Length:171
Mass (Da):18,951
Last modified:July 19, 2004 - v1
Checksum:i10617F0F28536A13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG41263.1.
RefSeqiWP_000684746.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41263; CAG41263; SAR2285.
KEGGisar:SAR2285.
PATRICi19548237. VBIStaAur71814_2295.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA. Translation: CAG41263.1.
RefSeqiWP_000684746.1. NC_002952.2.

3D structure databases

ProteinModelPortaliQ6GEN5.
SMRiQ6GEN5. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG41263; CAG41263; SAR2285.
KEGGisar:SAR2285.
PATRICi19548237. VBIStaAur71814_2295.

Phylogenomic databases

HOGENOMiHOG000226301.
KOiK01819.
OMAiETHHANQ.
OrthoDBiEOG679TJ4.

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.
BioCyciSAUR282458:GJA5-2325-MONOMER.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01556. LacB.
InterProiIPR004784. LacB.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01119. lacB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiLACB_STAAR
AccessioniPrimary (citable) accession number: Q6GEN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: March 16, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.