SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6GEK3

- SECY_STAAR

UniProt

Q6GEK3 - SECY_STAAR

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Protein translocase subunit SecY

Gene
secY, SAR2315
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity.UniRule annotation

GO - Biological processi

  1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
  2. protein targeting Source: UniProtKB-HAMAP
  3. protein transport by the Sec complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2358-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Gene namesi
Name:secY
Ordered Locus Names:SAR2315
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821Helical; Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Reviewed predictionAdd
BLAST
Transmembranei117 – 13721Helical; Reviewed predictionAdd
BLAST
Transmembranei147 – 16721Helical; Reviewed predictionAdd
BLAST
Transmembranei179 – 19921Helical; Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Reviewed predictionAdd
BLAST
Transmembranei269 – 28921Helical; Reviewed predictionAdd
BLAST
Transmembranei308 – 32821Helical; Reviewed predictionAdd
BLAST
Transmembranei368 – 38821Helical; Reviewed predictionAdd
BLAST
Transmembranei389 – 40921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Protein translocase subunit SecYUniRule annotationPRO_0000131743Add
BLAST

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity.

Protein-protein interaction databases

STRINGi282458.SAR2315.

Structurei

3D structure databases

ProteinModelPortaliQ6GEK3.
SMRiQ6GEK3. Positions 13-425.

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201.
HOGENOMiHOG000080586.
KOiK03076.
OMAiAWNVQFY.
OrthoDBiEOG651SWP.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GEK3-1 [UniParc]FASTAAdd to Basket

« Hide

MIQTLVNFFR TKEVRNKIFF TLAMLVIFKI GTYIPAPGVN PAAFDNPQGS    50
QGATELLNTF GGGALKRFSI FAMGIVPYIT ASIVMQLLQM DIVPKFSEWA 100
KQGEVGRRKL NNVTRYLAIS LAFIQSIGMA FQFNNYLKGA LIINQSIMSY 150
LLIALVLTAG TAFLIWLGDQ ITQFGVGNGI SIIIFAGILS TLPASLIQFG 200
QTAFVGQEDT SLAWLKVLGL LVSLILLTVG AIYVLEAVRK IPIQYAKKQT 250
AQRLGSQATY LPLKVNSAGV IPVIFAMAFF LLPRTLTLFY PDKEWAQNIA 300
NAANPSSNVG MVVYIVLIIL FTYFYAFVQV NPEKMADNLK KQGSYVPGIR 350
PGEQTKKYIT KVLYRLTFVG SIFLAVISIL PILATKFMGL PQSIQIGGTS 400
LLIVIGVAIE TMKSLEAQVS QKEYKGFGGR 430
Length:430
Mass (Da):47,148
Last modified:July 19, 2004 - v1
Checksum:i31B735FEC788F1E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41296.1.
RefSeqiYP_041670.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41296; CAG41296; SAR2315.
GeneIDi2859137.
KEGGisar:SAR2315.
PATRICi19548301. VBIStaAur71814_2327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41296.1 .
RefSeqi YP_041670.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GEK3.
SMRi Q6GEK3. Positions 13-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR2315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG41296 ; CAG41296 ; SAR2315 .
GeneIDi 2859137.
KEGGi sar:SAR2315.
PATRICi 19548301. VBIStaAur71814_2327.

Phylogenomic databases

eggNOGi COG0201.
HOGENOMi HOG000080586.
KOi K03076.
OMAi AWNVQFY.
OrthoDBi EOG651SWP.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-2358-MONOMER.

Family and domain databases

Gene3Di 1.10.3370.10. 1 hit.
HAMAPi MF_01465. SecY.
InterProi IPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view ]
PANTHERi PTHR10906. PTHR10906. 1 hit.
Pfami PF00344. SecY. 1 hit.
[Graphical view ]
PIRSFi PIRSF004557. SecY. 1 hit.
SUPFAMi SSF103491. SSF103491. 1 hit.
TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
PROSITEi PS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiSECY_STAAR
AccessioniPrimary (citable) accession number: Q6GEK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi