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Q6GEK3

- SECY_STAAR

UniProt

Q6GEK3 - SECY_STAAR

Protein

Protein translocase subunit SecY

Gene

secY

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

    GO - Biological processi

    1. intracellular protein transmembrane transport Source: UniProtKB-HAMAP
    2. protein targeting Source: UniProtKB-HAMAP
    3. protein transport by the Sec complex Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Protein transport, Translocation, Transport

    Enzyme and pathway databases

    BioCyciSAUR282458:GJA5-2358-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein translocase subunit SecYUniRule annotation
    Gene namesi
    Name:secYUniRule annotation
    Ordered Locus Names:SAR2315
    OrganismiStaphylococcus aureus (strain MRSA252)
    Taxonomic identifieri282458 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000596: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: GOC
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430Protein translocase subunit SecYPRO_0000131743Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

    Protein-protein interaction databases

    STRINGi282458.SAR2315.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6GEK3.
    SMRiQ6GEK3. Positions 13-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalUniRule annotationAdd
    BLAST
    Transmembranei68 – 8821HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei147 – 16721HelicalUniRule annotationAdd
    BLAST
    Transmembranei179 – 19921HelicalUniRule annotationAdd
    BLAST
    Transmembranei217 – 23721HelicalUniRule annotationAdd
    BLAST
    Transmembranei269 – 28921HelicalUniRule annotationAdd
    BLAST
    Transmembranei308 – 32821HelicalUniRule annotationAdd
    BLAST
    Transmembranei368 – 38821HelicalUniRule annotationAdd
    BLAST
    Transmembranei389 – 40921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SecY/SEC61-alpha family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0201.
    HOGENOMiHOG000080586.
    KOiK03076.
    OMAiAWNVQFY.
    OrthoDBiEOG651SWP.

    Family and domain databases

    Gene3Di1.10.3370.10. 1 hit.
    HAMAPiMF_01465. SecY.
    InterProiIPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view]
    PANTHERiPTHR10906. PTHR10906. 1 hit.
    PfamiPF00344. SecY. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004557. SecY. 1 hit.
    SUPFAMiSSF103491. SSF103491. 1 hit.
    TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
    PROSITEiPS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6GEK3-1 [UniParc]FASTAAdd to Basket

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    MIQTLVNFFR TKEVRNKIFF TLAMLVIFKI GTYIPAPGVN PAAFDNPQGS    50
    QGATELLNTF GGGALKRFSI FAMGIVPYIT ASIVMQLLQM DIVPKFSEWA 100
    KQGEVGRRKL NNVTRYLAIS LAFIQSIGMA FQFNNYLKGA LIINQSIMSY 150
    LLIALVLTAG TAFLIWLGDQ ITQFGVGNGI SIIIFAGILS TLPASLIQFG 200
    QTAFVGQEDT SLAWLKVLGL LVSLILLTVG AIYVLEAVRK IPIQYAKKQT 250
    AQRLGSQATY LPLKVNSAGV IPVIFAMAFF LLPRTLTLFY PDKEWAQNIA 300
    NAANPSSNVG MVVYIVLIIL FTYFYAFVQV NPEKMADNLK KQGSYVPGIR 350
    PGEQTKKYIT KVLYRLTFVG SIFLAVISIL PILATKFMGL PQSIQIGGTS 400
    LLIVIGVAIE TMKSLEAQVS QKEYKGFGGR 430
    Length:430
    Mass (Da):47,148
    Last modified:July 19, 2004 - v1
    Checksum:i31B735FEC788F1E4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG41296.1.
    RefSeqiYP_041670.1. NC_002952.2.

    Genome annotation databases

    EnsemblBacteriaiCAG41296; CAG41296; SAR2315.
    GeneIDi2859137.
    KEGGisar:SAR2315.
    PATRICi19548301. VBIStaAur71814_2327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX571856 Genomic DNA. Translation: CAG41296.1 .
    RefSeqi YP_041670.1. NC_002952.2.

    3D structure databases

    ProteinModelPortali Q6GEK3.
    SMRi Q6GEK3. Positions 13-425.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 282458.SAR2315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG41296 ; CAG41296 ; SAR2315 .
    GeneIDi 2859137.
    KEGGi sar:SAR2315.
    PATRICi 19548301. VBIStaAur71814_2327.

    Phylogenomic databases

    eggNOGi COG0201.
    HOGENOMi HOG000080586.
    KOi K03076.
    OMAi AWNVQFY.
    OrthoDBi EOG651SWP.

    Enzyme and pathway databases

    BioCyci SAUR282458:GJA5-2358-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3370.10. 1 hit.
    HAMAPi MF_01465. SecY.
    InterProi IPR026593. SecY.
    IPR002208. SecY/SEC61-alpha.
    IPR023201. SecY_su_dom.
    [Graphical view ]
    PANTHERi PTHR10906. PTHR10906. 1 hit.
    Pfami PF00344. SecY. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004557. SecY. 1 hit.
    SUPFAMi SSF103491. SSF103491. 1 hit.
    TIGRFAMsi TIGR00967. 3a0501s007. 1 hit.
    PROSITEi PS00755. SECY_1. 1 hit.
    PS00756. SECY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MRSA252.

    Entry informationi

    Entry nameiSECY_STAAR
    AccessioniPrimary (citable) accession number: Q6GEK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3