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Q6GEC4

- FDHL_STAAR

UniProt

Q6GEC4 - FDHL_STAAR

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Protein
Putative formate dehydrogenase SAR2393
Gene
SAR2393
Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 4 4Fe-4S clusters By similarity.
Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. electron carrier activity Source: InterPro
  4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  5. molybdenum ion binding Source: InterPro

GO - Biological processi

  1. formate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

Enzyme and pathway databases

BioCyciSAUR282458:GJA5-2437-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase SAR2393 (EC:1.2.1.2)
Gene namesi
Ordered Locus Names:SAR2393
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000596: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 984984Putative formate dehydrogenase SAR2393
PRO_0000304130Add
BLAST

Proteomic databases

PRIDEiQ6GEC4.

Interactioni

Protein-protein interaction databases

STRINGi282458.SAR2393.

Structurei

3D structure databases

ProteinModelPortaliQ6GEC4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 79772Fe-2S ferredoxin-type
Add
BLAST
Domaini138 – 165284Fe-4S ferredoxin-type 1
Add
BLAST
Domaini181 – 211314Fe-4S ferredoxin-type 2
Add
BLAST
Domaini257 – 313574Fe-4S Mo/W bis-MGD-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 984733Formate dehydrogenase
Add
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG3383.
HOGENOMiHOG000031440.
KOiK00123.
OMAiMHIDAFV.
OrthoDBiEOG6CVV7G.

Family and domain databases

InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamiPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFiPIRSF036643. FDH_alpha. 1 hit.
SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6GEC4-1 [UniParc]FASTAAdd to Basket

« Hide

MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT    50
CTVEIDGKIE RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT 100
VCDYNNGDCE IHNTMDAWGL QHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
GRCVEACQDI ELNETIRIDW DREHPRVIWD NDVPINESSC VSCGQCATVC 200
PCNAMMEVNM EGNAGYMTDT EPGSLAAMID LTKKAEPGYG PLFAISDSEA 250
EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 300
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKHG 350
PDALSFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
TVGHGGDSGS IEDLEKAAMS VLIGTNTAEA HPVIASRMKR AQKLFGQKIH 450
VFDIRKHEMA ERADRFYQPK PGTDLAWLSA VTKYIIDHDL HDKAFIEEWV 500
EDFDEYYKSL ETFTMAFAEE ATGIPEAELI KFAEECAKAE SVVICWAMGI 550
TQQDIGSDSS TAISNLLLVT GNYRRPGTGA YPLRGHNNVQ GCSDIGSMPD 600
KITGYQSIEA DDIRAKFEKE YGVKLNPKAG KDNHEMVEGI HDGQIHSLYL 650
YGEDTGIVDS NINFVQAAFE KLDFMVVQDE FLTFTATYAD VVLPASPSLE 700
KDGTFTNTER RIQRLYQALK PLGDSKPDWK IFQAIANKLS FDWNYKHPSE 750
IMDEIARLTP LYAGVSYERL EGFNSLQWPV HPDGTDEPIL YLEGFNFDNG 800
KAKLFPLSFD NYFKQDEVYD IHVNNGRLLE HFHEGNMTYQ TPMLKYKVPR 850
AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 900
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRMEVIT KRGKSPLNPN 950
NFRVNKKRHP QYSVQVQKKW ERPDYVFPGN QVDK 984
Length:984
Mass (Da):111,342
Last modified:July 19, 2004 - v1
Checksum:iFE1153208DAD5F33
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41375.1.
RefSeqiYP_041749.1. NC_002952.2.

Genome annotation databases

EnsemblBacteriaiCAG41375; CAG41375; SAR2393.
GeneIDi2859010.
KEGGisar:SAR2393.
PATRICi19548465. VBIStaAur71814_2411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX571856 Genomic DNA. Translation: CAG41375.1 .
RefSeqi YP_041749.1. NC_002952.2.

3D structure databases

ProteinModelPortali Q6GEC4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 282458.SAR2393.

Proteomic databases

PRIDEi Q6GEC4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG41375 ; CAG41375 ; SAR2393 .
GeneIDi 2859010.
KEGGi sar:SAR2393.
PATRICi 19548465. VBIStaAur71814_2411.

Phylogenomic databases

eggNOGi COG3383.
HOGENOMi HOG000031440.
KOi K00123.
OMAi MHIDAFV.
OrthoDBi EOG6CVV7G.

Enzyme and pathway databases

BioCyci SAUR282458:GJA5-2437-MONOMER.

Family and domain databases

InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view ]
Pfami PF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF036643. FDH_alpha. 1 hit.
SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MRSA252.

Entry informationi

Entry nameiFDHL_STAAR
AccessioniPrimary (citable) accession number: Q6GEC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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