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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107Proton acceptorUniRule annotation1
Binding sitei125SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:SAR2422
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001584661 – 228Ribose-5-phosphate isomerase AAdd BLAST228

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GE99
SMRiQ6GE99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 32Substrate bindingUniRule annotation4
Regioni85 – 88Substrate bindingUniRule annotation4
Regioni98 – 101Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000276369
KOiK01807
OMAiVAPMAYV

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GE99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVKALKLM TLNDVLSQIN GDMTLGIGTG STMELLLPQM AQLIKERGYN
60 70 80 90 100
ITGVCTSNKI AFLAKELGIK ICEINDVDHI DLAIDGADEV DPSLNIIKGG
110 120 130 140 150
GGALFREKVI DEMASRFVVV VDETKMVQYL GETFKLPVEV DKFNWYHILR
160 170 180 190 200
KIESYADIKV ERRVNEDVAF ITDNGNYILD CKLPKGIDPY KFHEYLIHLT
210 220
GVFETGYFLD MADQVIVGTQ EGVKILEK
Length:228
Mass (Da):25,568
Last modified:July 19, 2004 - v1
Checksum:i1EDEEB5DD3C055D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG41402.1
RefSeqiWP_000655867.1, NC_002952.2

Genome annotation databases

EnsemblBacteriaiCAG41402; CAG41402; SAR2422
KEGGisar:SAR2422

Similar proteinsi

Entry informationi

Entry nameiRPIA_STAAR
AccessioniPrimary (citable) accession number: Q6GE99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health