Reviewed, UniProtKB/Swiss-Prot Q6GE66 (MQO1_STAAR)

Names and origin

Protein names

Recommended name:
    Probable malate:quinone oxidoreductase 1
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor] 1
    MQO 1

Gene names

Name:	mqo1
Ordered Locus Names:	SAR2454

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor. HAMAP MF_00212
Cofactor	FAD By similarity. HAMAP MF_00212
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Probable malate:quinone oxidoreductase 1 HAMAP MF_00212		PRO_0000128743

Sequences

	Sequence		Length	Mass (Da)
	Q6GE66-1 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 703CEDB76C0E9ABF	FASTA	492	54,871
	10 20 30 40 50 60 MTTQHSKTDV ILIGGGIMSA TLGTLLKELS PEKNIKVFEK LAQPGEESSN VWNNAGTGHS 70 80 90 100 110 120 ALCELNYTKE GKDGTVDCSK AIKINEQYQI SKQFWAYLVK TGQLDNPDRF IQAVPHMSFV 130 140 150 160 170 180 IGEDNVAFIK SRVATLKKNV LFEKMKLSQD EEEMKSWVPL MIEGRKSDEP IALTYDETGT 190 200 210 220 230 240 DVNFGALTAK LFDNLEQRGV EIQYKQNVLD IKKQKSGAWL VKVKDLETNE TTTYESDFVF 250 260 270 280 290 300 IGAGGASLPL LQKTGIKQSK HIGGFPVSGL FLRCTNQEVI DRHHAKVYGK AAVGAPPMSV 310 320 330 340 350 360 PHLDTRFVDG KRSLLFGPFA GFSPKFLKTG SHMDLIKSVK PNNIVTMLSA GIKEMSLTKY 370 380 390 400 410 420 LVSQLMLSND ERMDDLRVFF PNAKNEDWEV ITAGQRVQVI KDTEDSKGNL QFGTEVITSD 430 440 450 460 470 480 DGTLAALLGA SPGASTAVDI MFDVLQRCYR DEFKGWEPKI KEMVPSFGYR LTDHEDLYHK 490 INEEVTKYLQ VK

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG41436.1. Different initiation.
RefSeq	YP_041807.2.
3D structure databases
SMR	Q6GE66. Positions 5-256.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GE66.
Genome annotation databases
GeneID	2861307.
GenomeReviews	Gene locus SAR2454 in contig BX571856_GR.
KEGG	sar:SAR2454.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0579.
HOGENOM	HBG289663.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR2454-MONOMER.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO1_STAAR

Accession

Primary (citable) accession number: Q6GE66

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	February 9, 2010
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)