Q6GDQ3 (Q6GDQ3_STAAR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase EMBL CAG41604.1
EC=1.1.1.88 EMBL CAG41604.1

Gene names

Name:	mvaA EMBL CAG41604.1
Ordered Locus Names:	SAR2625

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP]

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	426 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU004269 EMBL CAG41604.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6GDQ3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 656224E5FEEB4DF4	FASTA	426	46,314
	10 20 30 40 50 60 MQSLDKNFRH LSRQQKLQQL VDKQWLSEEQ FNILLNHPLI DEEVANSLIE NVIAQGALPV 70 80 90 100 110 120 GLLPNIIVDD KAYVVPMMVE EPSVVAAASY GAKLVNQTGG FKTVSSERIM IGQIVFDGVD 130 140 150 160 170 180 DTEKLSADIK ALEKQIHQIA DEAYPSIKAR GGGYQRIAID TFPEQQLLSL KVFVDTKDAM 190 200 210 220 230 240 GANMLNTILE AITAFLKNEF PQSDILMSIL SNHATASVVK VQGEIDVKDL ARGERTGEEV 250 260 270 280 290 300 AKRMERASVL AQVDIHRAAT HNKGVMNGIH AVVLATGNDT RGAEASAHAY ASKDGQYRGI 310 320 330 340 350 360 ATWRYDQERQ RLIGTIEVPM TLAIVGGGTK VLPIAKASLE LLNVESAQEL GHVVAAVGLA 370 380 390 400 410 420 QNFAACRALV SEGIQQGHMS LQYKSLAIVV GAKGDEIAQV AEALKQEPRA NTQVAERILQ DLRSQQ

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed: 15213324] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG41604.1.
RefSeq	YP_041970.1. NC_002952.2.
3D structure databases
ProteinModelPortal	Q6GDQ3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6GDQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000019588; EBSTAP00000018924; EBSTAG00000019587.
GeneID	2861328.
GenomeReviews	Gene locus SAR2625 in contig BX571856_GR.
KEGG	sar:SAR2625.
PATRIC	19548952. VBIStaAur71814_2654.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1257.
GeneTree	EBGT00050000024128.
HOGENOM	HBG477902.
OMA	NNKGIMN.
PhylomeDB	Q6GDQ3.
ProtClustDB	CLSK886059.
Enzyme and pathway databases
BioCyc	SAUR282458:SAR2625-MONOMER.
Family and domain databases
InterPro	IPR002202. HMG_CoA_Rdtase. IPR004553. HMG_CoA_Rdtase_bac-typ. IPR023074. HMG_CoA_Rdtase_cat. IPR023076. HMG_CoA_Rdtase_CS. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. [Graphical view]
Gene3D	G3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit. G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
KO	K00054.
Pfam	PF00368. HMG-CoA_red. 1 hit. [Graphical view]
PRINTS	PR00071. HMGCOARDTASE.
SUPFAM	SSF55035. HMG_CoA_NAD_bind. 1 hit. SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMs	TIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITE	PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS01192. HMG_COA_REDUCTASE_3. 1 hit. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q6GDQ3_STAAR

Accession

Primary (citable) accession number: Q6GDQ3

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)