Q6GDK3 (Q6GDK3_STAAR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-dehydropantoate 2-reductase RuleBase RU003776
EC=1.1.1.169 RuleBase RU003776

Gene names

Ordered Locus Names:

SAR2678

Organism

Staphylococcus aureus (strain MRSA252) [Complete proteome] [HAMAP] EMBL CAG41655.1

Taxonomic identifier

282458 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity. RuleBase RU003776
Catalytic activity	(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH. RuleBase RU003776
Sequence similarities	Belongs to the ketopantoate reductase family. RuleBase RU003776

Ontologies

Keywords
Biological process	Pantothenate biosynthesis RuleBase RU003776
Ligand	NADP RuleBase RU003776
Molecular function	Oxidoreductase RuleBase RU003776
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	2-dehydropantoate 2-reductase activity Inferred from electronic annotation. Source: EC NADP binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6GDK3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 11E2B2381664435F	FASTA	286	32,424
	10 20 30 40 50 60 MLSVAIIGPG AVGTTIVYEL QQSLPHTTLI GRHAKTITYY TVPHAPAQDI VVKGYEDVTN 70 80 90 100 110 120 TFDVIIIAVK THQLDAVIPH LTHLAHEDTL IILAQNGYGQ LEHIPFKNVC QAVVYISGQK 130 140 150 160 170 180 KGDVVTHFRD YQLRIQDNAL TRQFRDLVQD SQIDIVLEAN IQQAIWYKLL VNLGINSITA 190 200 210 220 230 240 LGRQTVAIMH NPEIRTLCRQ LLLDGCRVAQ AEGLNFSEQT VDTIMTIYQG YPDEMGTSMY 250 260 270 280 YDIVHQQPLE VEAIQGFIYR RAREHNLDTP YLDTIYSFLR AYQQNM

References

[1]

"Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. , Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z., Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N., Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M., Sharp S., Simmonds M., Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J. Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MRSA252.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX571856 Genomic DNA. Translation: CAG41655.1.
RefSeq	YP_042020.1. NC_002952.2.
3D structure databases
ProteinModelPortal	Q6GDK3.
ModBase	Search...
Protein-protein interaction databases
STRING	282458.SAR2678.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAG41655; CAG41655; SAR2678.
GeneID	2860586.
KEGG	sar:SAR2678.
PATRIC	19549064. VBIStaAur71814_2710.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1893.
HOGENOM	HOG000280297.
KO	K00077.
OMA	SKNICKL.
ProtClustDB	PRK12921.
Enzyme and pathway databases
BioCyc	SAUR282458:GJA5-2718-MONOMER.
Family and domain databases
Gene3D	1.10.1040.10. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR003710. ApbA. IPR013752. ApbA_C. IPR013332. ApbA_N. IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF02558. ApbA. 1 hit. PF08546. ApbA_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00745. apbA_panE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q6GDK3_STAAR

Accession

Primary (citable) accession number: Q6GDK3

Entry history

Integrated into UniProtKB/TrEMBL:	July 19, 2004
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)